Drug Administration Schedule

Publication Title: 
British Journal of Anaesthesia

BACKGROUND: In view of widespread claims of efficacy, we examined the evidence regarding the effects of hypnosis for pain relief during childbirth. METHODS: Medline, Embase, Pubmed, and the Cochrane library 2004.1 were searched for clinical trials where hypnosis during pregnancy and childbirth was compared with a non-hypnosis intervention, no treatment or placebo. Reference lists from retrieved papers and hypnotherapy texts were also examined. There were no language restrictions.

Author(s): 
Cyna, A. M.
McAuliffe, G. L.
Andrew, M. I.
Publication Title: 
British Journal of Anaesthesia

Postoperative pain management remains a significant challenge for all healthcare providers. The objective of this systematic review was to quantitatively evaluate the efficacy of acupuncture and related techniques as adjunct analgesics for acute postoperative pain management. We searched the databases of Medline (1966-2007), CINAHL, The Cochrane Central Register of Controlled Trials (2006), and Scopus for randomized controlled trials (RCTs) using acupuncture for postoperative pain management.

Author(s): 
Sun, Y.
Gan, T. J.
Dubose, J. W.
Habib, A. S.
Publication Title: 
British Journal of Anaesthesia

Postoperative pain management remains a significant challenge for all healthcare providers. The objective of this systematic review was to quantitatively evaluate the efficacy of acupuncture and related techniques as adjunct analgesics for acute postoperative pain management. We searched the databases of Medline (1966-2007), CINAHL, The Cochrane Central Register of Controlled Trials (2006), and Scopus for randomized controlled trials (RCTs) using acupuncture for postoperative pain management.

Author(s): 
Sun, Y.
Gan, T. J.
Dubose, J. W.
Habib, A. S.
Publication Title: 
JAMA internal medicine

IMPORTANCE: When analyzing results of randomized clinical trials, the treatment with the greatest specific effect compared with its placebo control is considered to be the most effective one. Although systematic variations of improvements in placebo control groups would have important implications for the interpretation of placebo-controlled trials, the knowledge base on the subject is weak. OBJECTIVE: To investigate whether different types of placebo treatments are associated with different responses using the studies of migraine prophylaxis for this analysis.

Author(s): 
Meissner, Karin
Fässler, Margrit
Rücker, Gerta
Kleijnen, Jos
Hróbjartsson, Asbjorn
Schneider, Antonius
Antes, Gerd
Linde, Klaus
Publication Title: 
Human & Experimental Toxicology

HP-1 a herbal formulation comprising of Phyllanthus niruri and extracts of Terminalia belerica, Terminalia chebula, Phyllanthus emblica and Tinospora cordifolia has been evaluated for hepatoprotective activity against carbon tetrachloride (CCl4) induced toxicity. Results show that HP-1 reversed the leakage of lactate dehydrogenase (LDH) and glutamate pyruvate transaminase (GPT) and prevented the depletion of glutathione (GSH) levels in a primary monolayer culture of rat hepatocytes (in vitro).

Author(s): 
Tasaduq, S. A.
Singh, K.
Sethi, S.
Sharma, S. C.
Bedi, K. L.
Singh, J.
Jaggi, B. S.
Johri, R. K.
Publication Title: 
Journal of thrombosis and haemostasis: JTH

BACKGROUND: Thromboprophylaxis with rivaroxaban (R) is superior to enoxaparin in patients undergoing major orthopedic surgery (MOS). However, rivaroxaban has never been directly compared with fondaparinux (F), which also shows superior efficacy over enoxaparin. The clinical impact of switching from fondaparinux to rivaroxaban thromboprophylaxis is unclear. OBJECTIVES: To evaluate the efficacy and safety of rivaroxaban or fondaparinux thromboprophylaxis in unselected patients undergoing MOS.

Author(s): 
Beyer-Westendorf, J.
L¸tzner, J.
Donath, L.
Radke, O. C.
Kuhlisch, E.
Hartmann, A.
Weiss, N.
Werth, S.
Publication Title: 
The American Journal of Psychiatry

OBJECTIVE: The authors compared the effectiveness of fluoxetine and desipramine treatment in a prospective double-blind pharmacogenetics study in first-generation Mexican Americans and examined the role of whole-exome functional gene variations in the patients' antidepressant response. METHOD: A total of 232 Mexican Americans who met DSM-IV criteria for major depressive disorder were randomly assigned to receive 8 weeks of double-blind treatment with desipramine (50-200 mg/day) or fluoxetine (10-40 mg/day) after a 1-week placebo lead-in period.

Author(s): 
Wong, Ma-Li
Dong, Chuanhui
Flores, Deborah L.
Ehrhart-Bornstein, Monika
Bornstein, Stefan
Arcos-Burgos, Mauricio
Licinio, Julio
Publication Title: 
Journal of Affective Disorders

The present study aimed at investigating the possible changes of some features of loving relationships during long-term treatment of depression with both selective serotonin reuptake inhibitors (SSRIs) and tricyclics (TCAs), by means of a specifically designed test, the so-called "Sex, Attachment, Love" (SALT) questionnaire.

Author(s): 
Marazziti, Donatella
Akiskal, Hagop S.
Udo, Mieko
Picchetti, Michela
Baroni, Stefano
Massimetti, Gabriele
Albanese, Francesco
Dell'Osso, Liliana
Publication Title: 
The American Journal of Pediatric Hematology/Oncology
Author(s): 
LeBaron, S.
Zeltzer, L.
Publication Title: 
British Journal of Anaesthesia

We have studied the effect of nitrous oxide on bispectral index (BIS), calculated from a bipolar encephalogram. Inhalation of 70% nitrous oxide resulted in loss of consciousness in all healthy volunteers (n = 10) but no change in BIS. Brief inhalation up to 1.2% sevoflurane also resulted in loss of consciousness in volunteers (n = 5), but with sevoflurane, BIS decreased. BIS and the haemodynamic effects of adding nitrous oxide were also measured during coronary artery bypass surgery in patients (n = 10) receiving midazolam and fentanyl infusions.

Author(s): 
Barr, G.
Jakobsson, J. G.
Owall, A.
Anderson, R. E.

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