Drug Administration Schedule

Publication Title: 
Tropical medicine & international health: TM & IH

A randomized, open trial involving 260 Tanzanian children, aged 1-5 years, with acute Plasmodium falciparum malaria was conducted to evaluate the efficacy of the combination antimalarial CGP 56697 (artemether and benflumetol), and to compare it with chloroquine, the standard drug used for malaria treatment in the Kilombero area. Children who had received rescue medication within the first 48 h or had a negative slide at the same time were excluded. Seven-day parasitological cure rates were 94% (95% CI 88-97.5) for CGP 56697 and 35.4% (95% CI 25.9-45.8) for chloroquine.

Author(s): 
Hatz, C.
Abdulla, S.
Mull, R.
Schellenberg, D.
Gathmann, I.
Kibatala, P.
Beck, H. P.
Tanner, M.
Royce, C.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

CGP 56697, a new oral fixed combination of artemether and benflumetol, was tested in a double-blinded, randomized trial in 252 adult patients treated either with CGP 56697 (4 x 4 tablets each containing 20 mg of artemether and 120 mg of benflumetol, given at 0, 8, 24, and 48 hr), or with mefloquine (three tablets of 250 mg at initial diagnosis, followed by two tablets of 250 mg at 8 hr). Baseline data of the two groups were comparable. The 28-day cure rate with CGP 56697 was lower than with mefloquine (69.3% versus 82.4%; P = 0.002).

Author(s): 
Looareesuwan, S.
Wilairatana, P.
Chokejindachai, W.
Chalermrut, K.
Wernsdorfer, W.
Gemperli, B.
Gathmann, I.
Royce, C.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

AIM: To study the effect of artemether (Art) for prevention of schistosomal infection. METHODS: Rabbits with single infection or reinfection with Schistosoma japonicum cercariae were treated intramuscularly (i.m.) or intragastrically (i.g.) with Art 5 -20 mg.kg-1 on d 7-15 after the first infection, followed by various regimens. RESULTS: When rabbits were injected i.m. Art 7.5 mg.kg-1 (i.e., one half of the effective dose given i.g. on d 7) followed by once every week for twice, the female worm reduction rate was only 42%. In infected rabbits treated i.g.

Author(s): 
Xiao, S. H.
You, J. Q.
Mei, J. Y.
Jiao, P. Y.
Guo, H. F.
Feng, Z.
Publication Title: 
Tropical medicine & international health: TM & IH

We conducted a randomized, comparative trial at the Bangkok Hospital for Tropical Diseases during 1996-98 to evaluate the clinical efficacy and tolerability of four combination regimens of dihydroartemisinin-mefloquine.

Author(s): 
Na-Bangchang, K.
Tippanangkosol, P.
Ubalee, R.
Chaovanakawee, S.
Saenglertsilapachai, S.
Karbwang, J.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

Intramuscular injections of high doses of the oil-soluble antimalarial artemisinin derivatives artemether and arteether produce an unusual pattern of selective damage to brain stem centers in experimental mammals, predominantly those involved in auditory processing and vestibular reflexes. We have shown recently in adult Swiss albino mice that parenteral artesunate, a water-soluble derivative, is significantly less neurotoxic than intramuscular artemether in this murine model.

Author(s): 
Nontprasert, A.
Pukrittayakamee, S.
Nosten-Bertrand, M.
Vanijanonta, S.
White, N. J.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

The qinghaosu (artemisinin) group of drugs is the most important new class of antimalarials developed in the last fifty years. Although there has been no clinical evidence of neurotoxicity, an unusual pattern of damage to specific brain-stem nuclei has been reported in experimental animals receiving high doses of arteether or artemether.

Author(s): 
Kissinger, E.
Hien, T. T.
Hung, N. T.
Nam, N. D.
Tuyen, N. L.
Dinh, B. V.
Mann, C.
Phu, N. H.
Loc, P. P.
Simpson, J. A.
White, N. J.
Farrar, J. J.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

One hundred and fifty patients with severe falciparum malaria were administered sequential combination of dihydroartemisinin suppository followed by an oral mefloquine tablet. Dihydroartemisinin suppositories (80 mg/capsule) were given rectally once daily for 3 days with a total dose of 8-10 mg/kg. Two doses of mefloquine, 15 mg/kg/dose and 10 mg/kg/dose, were given at 72 hr and 84 hr, respectively. The mean [SD] parasite clearance time and fever clearance time were 46.1 [15.7] hr and 82.5 [59.6] hr, respectively. No death or major adverse drug effects occurred.

Author(s): 
Wilairatna, P.
Krudsood, S.
Silachamroon, U.
Singhasivanon, P.
Vannaphan, S.
Faithong, S.
Klabprasit, M.
Bangchang, S. N.
Olliaro, P.
Looareesuwan, S.
Publication Title: 
British Journal of Clinical Pharmacology

AIMS: To investigate whether coadministration of the antimalarials artesunate and artemisinin alters the clearance of either drug. METHODS: Ten healthy Vietnamese males (Group AS) were randomized to receive a single dose of 100 mg oral artesunate (pro-drug of dihydroartemisinin) on day -5 and then once daily for 5 consecutive days (days 1-5). Oral artemisinin (500 mg) was coadministered on days 1 and 5. Another 10 subjects (Group AM) were given 500 mg oral artemisinin on day -5 and then further doses on days 1-5. Artesunate 100 mg was given on days 1 and 5.

Author(s): 
Zhang, S. Q.
Hai, T. N.
Ilett, K. F.
Huong, D. X.
Davis, T. M.
Ashton, M.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

The efficacy of artemisinin monotherapy was studied in 227 patients with uncomplicated falciparum malaria. They all received artemisinin at t = 0 hr, t = 8 hr, and thereafter once daily; treatment was extended at random until they had taken either 5 days of artemisinin followed by 2 days of placebo (A5), or 7 days (A7) of artemisinin. The adult artemisinin dose was 500 mg; children aged < 15 years received 10 mg/kg per dose. The median (range) parasite clearance time was 39 (8-112) hr for A5 and 43 (38-104) hr for A7 (P = 0.085). The recrudescence rates were similar between the groups.

Author(s): 
Giao, P. T.
Binh, T. Q.
Kager, P. A.
Long, H. P.
Van Thang, N.
Van Nam, N.
de Vries, P. J.
Publication Title: 
The Korean Journal of Parasitology

The purpose of treatment for uncomplicated malaria is to produce a radical cure using the combination of: artesunate (4 mg/kg/day) plus mefloquine (8 mg/kg day) for 3 days: a fixed dose of artemether and lumefantrine (20/120 mg tablet) named Coartem (4 tablets twice a day for three days for adults weighing more than 35 kg): quinine 10 mg/kg 8-hourly plus tetracycline 250 mg 6-hourly for 7 days (or doxycycline 200 mg as an alternative to tetracycline once a day for 7 days) in patients aged 8 years and over: Malarone (in adult 4 tablets daily for 3 days).

Author(s): 
Silachamroon, Udomsak
Krudsood, Srivicha
Phophak, Nanthaphorn
Looareesuwan, Sornchai

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