Drug-Induced Liver Injury

Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics
Author(s): 
Indacochea-Redmond, N.
Witschi, H.
Plaa, G. L.
Publication Title: 
Drug and Chemical Toxicology

An iridoid glucoside, aucubin was isolated from Aucuba japonica leaves and its protective activities against CCl4-induced hepatotoxicity were evaluated by measuring the duration of hypnosis induced by hexobarbital after CCl4 challenge (0.2 ml/kg/day, po) and the levels of serum glutamic-oxalacetic (GOT) and serum glutamic-pyruvic transaminase (GPT). The duration of hypnosis for the saline control group, the CCl4 alone treated group and the aucubin plus CCl4 treated group was 24.8 +/- 8.5, 60.5 +/- 9.5 and 28.0 +/- 3.2 min, respectively.

Author(s): 
Chang, I. M.
Ryu, J. C.
Park, Y. C.
Yun, H. S.
Yang, K. H.
Publication Title: 
Malaria Journal

BACKGROUND: Artemisinin-based combination therapy (ACT) is being widely promoted as a strategy to counteract the increase in Plasmodium falciparum antimalarial drug resistance. METHODS: A randomized, double-blind, placebo-controlled, clinical trial of the efficacy, effect on gametocytes and safety of the addition of artesunate/placebo (4 mg/kg/day x 3 d) to amodiaquine (10 mg/kg/day x 3 d) was conducted in Choco department, a low intensity transmission area in northwest Colombia.

Author(s): 
Osorio, Lyda
Gonzalez, Iveth
Olliaro, Piero
Taylor, Walter R. J.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

Amodiaquine is an amino-4-quinoline with the basic spectrum of activity of chloroquine. It has been used widely to treat and prevent malaria. From the mid-1980s, there were reports of fatal adverse drug reactions described in travelers using amodiaquine as antimalarial prophylaxis. In 1990, the World Health Organization (WHO) stopped using this drug in malaria control programs. The WHO Expert Committee on Malaria modified this in 1993 and reported that amodiaquine could be used for treatment if the risk of infection outweighs the potential for adverse drug reactions.

Author(s): 
Markham, Lydia Novisi
Giostra, Emiliano
Hadengue, Antoine
Rossier, Michel
Rebsamen, Michela
Desmeules, Jules
Publication Title: 
MMWR. Morbidity and mortality weekly report

Artemisinins are a class of compounds that include artesunate, artemether, and artemisinin and have potent antimalarial activity. In combination with other drugs (artemisinin combination therapy), these compounds are the first-line treatment recommended by the World Health Organization for Plasmodium falciparum infections. Artemisinins have been available in the United States without a prescription as herbal supplements for at least 10 years; these supplements are marketed for general health maintenance and for treatment of parasitic infections and cancers.

Author(s): 
Centers for Disease Control and Prevention (CDC)
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Carbon tetrachloride (CCl4) is a well-known hepatotoxin and exposure to this chemical is known to induce oxidative stress and causes liver injury by the formation of free radicals. Acute and chronic renal damage are also very common pathophysiologic disturbances caused by CCl4.

Author(s): 
Manna, Prasenjit
Sinha, Mahua
Sil, Parames C.
Publication Title: 
Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan

Bauhinia variegata (Leguminosae) commonly known as Kachnar, is widely used in Ayurveda as tonic to the liver. The present work was carried out to assess the potential of Bauhinia variegata bark as hepatoprotective agent. The hepatoprotective activity was investigated in carbon tetrachloride (CCl(4)) intoxicated Sprague-Dawley rats. Bauhinia variegata alcoholic Stem Bark Extract (SBE) at different doses (100 and 200 mg/kg) were administered orally to male Sprague-Dawley rats weighing between 100-120 g.

Author(s): 
Bodakhe, Surendra H.
Ram, Alpana
Publication Title: 
Asian Pacific journal of cancer prevention: APJCP

Sida rhombifolia ssp. retusa is a well established drug in the Ayurvedic system of medicine used for antirheumatism and antiasthmatism. Inhibitory effects of S. rhombifolia ssp. retusa seed extract on DEN induced hepatocellular preneoplastic foci and carbon tetrachloride (CCl4) induced hepatotoxicity was investigated in rats. Rats received DEN, 1ppm/g b.w. in drinking water for 6 weeks or CCl(4), 0.7 ml/kg i.p. once a week for 4 weeks and seed extract 50 mg, 100 mg/kg b.w. orally prior, during and after exposure to DEN/CCl4 for 20 or 5 weeks, respectively.

Author(s): 
Poojari, Radhika
Gupta, Sanjay
Maru, Girish
Khade, Bharat
Bhagwat, Sanjay
Publication Title: 
Journal of Ethnopharmacology

HD-03 is a polyherbal formulation containing plant drugs which are known for their hepatoprotective properties in the Ayurvedic system of medicine. In the present study, the formulation was evaluated for its protective effect against diverse hepatotoxic agents viz., paracetamol, thioacetamide and isoniazid. Treatment with HD-03 led to significant amelioration of toxin-induced changes in the biochemical parameters.

Author(s): 
Mitra, S. K.
Venkataranganna, M. V.
Sundaram, R.
Gopumadhavan, S.
Publication Title: 
Phytotherapy research: PTR

Glycowithanolides, consisting of equimolar concentrations of sitoindosides VII-X and withaferin A, isolated from the roots of Withania somnifera Dunal, have been reported to have an antioxidant effect in the rat brain frontal cortex and striatum. In the present study, the effect of 10 days of oral administration of these active principles, in graded doses (10, 20 and 50 mg/kg), was noted on iron overload (FeSo(4), 30 mg/kg, i.p.) induced hepatotoxicity in rats.

Author(s): 
Bhattacharya, A.
Ramanathan, M.
Ghosal, S.
Bhattacharya, S. K.

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