Drug Interactions

Publication Title: 
Complementary Therapies in Medicine

OBJECTIVE: To evaluate the scientific evidence on guggul for hyperlipidemia including expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing. METHODS: Electronic searches were conducted in nine databases, 20 additional journals (not indexed in common databases), and bibliographies from 50 selected secondary references. No restrictions were placed on language or quality of publications.

Author(s): 
Ulbricht, Catherine
Basch, Ethan
Szapary, Philippe
Hammerness, Paul
Axentsev, Serguei
Boon, Heather
Kroll, David
Garraway, Levi
Vora, Mamta
Woods, Jen
Natural Standard Research Collaboration
Publication Title: 
Drug Safety

Vitex agnus castus L. (VAC) [Verbenaceae] is a deciduous shrub that is native to Mediterranean Europe and Central Asia. Traditionally, VAC fruit extract has been used in the treatment of many female conditions, including menstrual disorders (amenorrhoea, dysmenorrhoea), premenstrual syndrome (PMS), corpus luteum insufficiency, hyperprolactinaemia, infertility, acne, menopause and disrupted lactation. The German Commission E has approved the use of VAC for irregularities of the menstrual cycle, premenstrual disturbances and mastodynia.

Author(s): 
Daniele, Claudia
Thompson Coon, Joanna
Pittler, Max H.
Ernst, Edzard
Publication Title: 
Clinical Therapeutics

BACKGROUND: Clinically relevant drug-drug interactions (DDIs) must be recognized in a timely manner and managed appropriately to prevent adverse drug reactions or therapeutic failure. Because the evidence for most DDIs is based on case reports or poorly documented clinical information, there is a need for better assessment of their clinical relevance.

Author(s): 
van Roon, Eric N.
van den Bemt, Patricia M. L. A.
Jansen, Tim L. Th A.
Houtman, Nella M.
van de Laar, Mart A. F. J.
Brouwers, Jacobus R. B. J.
Publication Title: 
Journal of trace elements in medicine and biology: organ of the Society for Minerals and Trace Elements (GMS)

Nickel, a major environmental pollutant is a known potent nephrotoxic agent. In this communication we report the chemopreventive effect of Terminalia chebula on nickel chloride (NiCl(2)) induced renal oxidative stress, toxicity and cell proliferation response in male Wistar rats.

Author(s): 
Prasad, Lakshmi
Husain Khan, Tajdar
Jahangir, Tamanna
Sultana, Sarwat
Publication Title: 
Journal of Neurochemistry

The search for effective treatments that prevent oxidative stress associated with premature ageing and neurodegenerative diseases is an important area of neurochemical research. As age- and disease-related oxidative stress is frequently associated with mitochondrial dysfunction, amphiphilic antioxidant agents of high stability and selectivity that target these organelles can provide on-site protection.

Author(s): 
Poeggeler, Burkhard
Durand, GrÈgory
Polidori, Ange
Pappolla, Miguel A.
Vega-Naredo, Ignacio
Coto-Montes, Ana
Bˆker, Jutta
Hardeland, R¸diger
Pucci, Bernard
Publication Title: 
Annals of Internal Medicine

Nutritional modulation is one approach to successful aging. In animals, dietary restriction increases life span. Alterations in the macronutrient and micronutrient constituent of the diet can modulate gene expression. Anorexia is common in elderly persons. The results of studies in animals suggest that aging is associated with a decrease in the opioid feeding drive and an increase in the satiating effect of cholecystokinin. Unrecognized depression is a common, treatable cause of anorexia and weight loss in elderly persons.

Author(s): 
Morley, J. E.
Mooradian, A. D.
Silver, A. J.
Heber, D.
Alfin-Slater, R. B.
Publication Title: 
Molecular and Cellular Biology

The ribonucleoprotein telomerase, a specialized cellular reverse transcriptase, synthesizes one strand of the telomeric DNA of eukaryotes. We analyzed telomere maintenance in two immortalized human cell lines: the B-cell line JY616 and the T-cell line Jurkat E6-1, and determined whether known inhibitors of retroviral reverse transcriptases could perturb telomere lengths and growth rates of these cells in culture. Dideoxyguanosine (ddG) caused reproducible, progressive telomere shortening over several weeks of passaging, after which the telomeres stabilized and remained short.

Author(s): 
Strahl, C.
Blackburn, E. H.
Publication Title: 
Molecular and Cellular Biology

The ribonucleoprotein telomerase, a specialized cellular reverse transcriptase, synthesizes one strand of the telomeric DNA of eukaryotes. We analyzed telomere maintenance in two immortalized human cell lines: the B-cell line JY616 and the T-cell line Jurkat E6-1, and determined whether known inhibitors of retroviral reverse transcriptases could perturb telomere lengths and growth rates of these cells in culture. Dideoxyguanosine (ddG) caused reproducible, progressive telomere shortening over several weeks of passaging, after which the telomeres stabilized and remained short.

Author(s): 
Strahl, C.
Blackburn, E. H.
Publication Title: 
Molecular Psychiatry

The last decade of research into the pharmacogenetics of antipsychotics has seen the development of genetic tests to determine the patients' metabolic status and the first attempts at personalization of antipsychotic treatment. The most significant results are the association between drug metabolic polymorphisms, mainly in cytochrome P450 genes, with variations in drug metabolic rates and side effects. Patients with genetically determined CYP2D6 poor metabolizer (PMs) status may require lower doses of antipsychotic.

Author(s): 
Arranz, M. J.
de Leon, J.
Publication Title: 
European Archives of Psychiatry and Clinical Neuroscience

Notwithstanding the considerable advances in the treatment options for schizophrenia, the cognitive symptoms in particular are not receptive to antipsychotic treatment and considered one of the main predictors for poor social and functional outcome of the disease. Recent findings in preclinical model systems indicate that epigenetic modulation might emerge as a promising target for the treatment of cognitive disorders.

Author(s): 
Hasan, Alkomiet
Mitchell, Amanda
Schneider, Anja
Halene, Tobias
Akbarian, Schahram

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