Drug-Related Side Effects and Adverse Reactions

Publication Title: 
Journal of Clinical Nursing

AIMS AND OBJECTIVES: This study sought to assess the impact of a standardized protocol to maintain nasoenteral tube (NET) patency in patients requiring fluid restriction and identify factors associated with tube patency. BACKGROUND: Nasoenteral tube obstruction may interrupt nutritional support and prohibit drug administration. Balancing NET patency in the context of fluid restriction can be a challenge. DESIGN AND METHODS: The impact of the standardized protocol was assessed by using a quasi-experimental design and an historical control.

Matsuba, Claudia St
De Gutiérrez, Maria Gr
Whitaker, Iveth Y.
Publication Title: 
Annals of Allergy, Asthma & Immunology: Official Publication of the American College of Allergy, Asthma, & Immunology

LEARNING OBJECTIVES: Reading this article will reinforce the reader's awareness of the adverse effects of medications used for the treatment of rhinitis. DATA SOURCES: Articles on therapy of rhinitis and reports of associated side effects were reviewed. A MEDLINE database using subject keywords was searched from 1992 through 1997. STUDY SELECTION: Pertinent articles were chosen. A distinction was made in the text between controlled studies and case reports.

Milgrom, H.
Bender, B.
Publication Title: 
Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology

PURPOSE: Adverse effects of chemotherapy can be severe and can have a significant impact on a person's quality of life. With chemotherapy treatment increasingly administered in the ambulatory setting, there is a need for patients to be informed about effective self-care strategies to manage treatment adverse effects. Advice for patients needs to be based on evidence.

Lotfi-Jam, Kerryann
Carey, Mariko
Jefford, Michael
Schofield, Penelope
Charleson, Catherine
Aranda, Sanchia
Publication Title: 
International Journal of Molecular Medicine

The sirtuin 1 protein (SIRT1) is a member of the class III NAD+-dependent histone deacetylases, which are also referred to as the 'sirtuins'. The sirtuins and silent information regulator 1 (SIRT1) in particular, are known to play a role in the response to DNA damage, metabolism, longevity and carcinogenesis. SIRT1 regulates different cellular processes such as proliferation, differentiation and apoptosis through deacetylation of important regulatory proteins such as p53, FOXO3a and NFkappaB.

Engel, Nicole
Mahlknecht, Ulrich
Publication Title: 
Trends in Pharmacological Sciences

Health problems are rising worldwide, be it as a consequence of lifestyle and longevity in increasingly affluent societies or due to a sharp rise in bacterial antibiotic resistance. The pharmaceutical industry is caught between high rates of attrition and the rather slow pace of a historically large regulatory system for pharmacological safety. Meanwhile, the past decade has seen a tremendous evolution of the biological toolbox, most notably of cellular assays, stem-cell differentiation and organ-mimicking systems. These systems were readily adapted for lead-compound identification.

Tralau, Tewes
Luch, Andreas
Publication Title: 
Clinical Pharmacology and Therapeutics

After a 16-week clinical trial of a new anti-inflammatory drug, the participants were given a factual test to determine whether they had understood and remembered the information given them when consent was solicited. They filled out a questionnaire about their reasons for volunteering and their views on clinical studies and on medical practice in general. Demographic information was also obtained. Two thirds of the participants did not remember that they had been informed about potential risk (gastrointestinal ulceration).

Hassar, M.
Weintraub, M.
Publication Title: 
International Journal of Clinical Pharmacology and Therapeutics

OBJECTIVE: To evaluate the personality characteristics of a group of participants in Phase 1 studies and to study the relation between the personality traits and the adverse events during participation. METHODS: Study population consisted of 139 healthy volunteers to Phase 1 studies. Personality was assessed through the Revised NEO Personality Inventory (NEO-PI-R) and adverse events were monitored during participation.

Almeida, L.
Falc„o, A.
Vaz-da-Silva, M.
Coelho, R.
Albino-Teixeira, A.
Soares-da-Silva, P.
Publication Title: 
Journal of Medical Ethics

OBJECTIVE: Recent legislation mandating the inclusion of children in clinical trials has resulted in an increase in the number of children participating in research. We reviewed the literature regarding the reasons parents chose to accept or decline an invitation to enroll their children in clinical research. METHODS: We searched for qualitative studies, written in the English language that considered the experiences of parents who had been invited to enrol their children in research.

Fisher, Helen R.
McKevitt, Christopher
Boaz, Annette
Publication Title: 
Journal of Clinical Pharmacy and Therapeutics

WHAT IS KNOWN AND OBJECTIVE: Adverse drug reactions to prescribed medication are relatively common events. However, the impact such reactions have on patients and their attitude to reporting such events have only been poorly explored. Previous studies relying on self-reporting patients indicate that altruism is an important factor. In the United Kingdom, patient reporting started in 2005; though, numbers of serious reports remain low.

Lorimer, S.
Cox, A.
Langford, N. J.
Publication Title: 
Archives of Neurology and Psychiatry
Dynes, J. B.


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