Drug Resistance, Bacterial

Publication Title: 
The Veterinary Record

Eighteen Norwegian dairy farmers were interviewed to examine their reasons for using homoeopathic treatments in managing their herds' health. Overall, they chose the treatments on the basis of factors related to their personal experience, considerations of individual animals and the framework for dairy production. For individual animals homoeopathy was used as an alternative to conventional veterinary treatment, but at the herd level it was used to complement it.

Author(s): 
Hektoen, L.
Publication Title: 
Phytotherapy research: PTR

The isolation of microbial agents less susceptible to regular antibiotics and the rising trend in the recovery rates of resistant bacteria highlights the need for newer alternative principles. Triphala has been used in traditional medicine practice against certain diseases such as jaundice, fever, cough, eye diseases etc.

Author(s): 
Srikumar, R.
Parthasarathy, N. Jeya
Shankar, E. M.
Manikandan, S.
Vijayakumar, R.
Thangaraj, R.
Vijayananth, K.
Sheeladevi, R.
Rao, Usha Anand
Publication Title: 
Indian Journal of Experimental Biology

"Triphala", the Ayurvedic wonder is used traditionally for the treatment of different types of diseases since antiquity. The hydroalcoholic extracts of the three components of Triphala powder demonstrated varying degrees of strain specific antibacterial activity against multidrug-resistant uropathogenic bacteria. Terminalia chebula fruit extract was active against all the test isolates followed by Terminalia belerica and Emblica officinalis.

Author(s): 
Bag, Anwesa
Bhattacharyya, Subir Kumar
Pal, Nishith Kumar
Publication Title: 
Antimicrobial Agents and Chemotherapy

Artemisinin (ART)-based combination therapies (ACTs) are the first-line drugs-and often the last treatments-that can effectively cure Plasmodium falciparum infections. Unfortunately, the decreased clinical efficacy of artesunate, one of the major ART derivatives, was recently reported along the Thailand-Cambodia border. Through long-term artemisinin pressure in vitro, we have obtained an ART-tolerant strain that can survive extremely high doses of ART.

Author(s): 
Witkowski, Benoit
Lelièvre, Joel
Barragán, María José López
Laurent, Victor
Su, Xin-Zhuan
Berry, Antoine
Benoit-Vical, Françoise
Publication Title: 
Antimicrobial Agents and Chemotherapy

This study describes the results of in vitro antimalarial susceptibility assays and molecular polymorphisms of Plasmodium falciparum isolates from Cambodia. The samples were collected from patients enrolled in therapeutic efficacy studies (TES) conducted by the Cambodian National Malaria Control Program for the routine efficacy monitoring of artemisinin-based combination therapy (ACT) (artesunate-mefloquine and artemether-lumefantrine combinations). The isolates (n = 2,041) were obtained from nine sentinel sites during the years 2001 to 2007.

Author(s): 
Lim, Pharath
Wongsrichanalai, Chansuda
Chim, Pheaktra
Khim, Nimol
Kim, Saorin
Chy, Sophy
Sem, Rithy
Nhem, Sina
Yi, Poravuth
Duong, Socheat
Bouth, Denis Mey
Genton, Blaise
Beck, Hans-Peter
Gobert, Jean Gerard
Rogers, William O.
Coppée, Jean-Yves
Fandeur, Thierry
Mercereau-Puijalon, Odile
Ringwald, Pascal
Le Bras, Jacques
Ariey, Frédéric
Publication Title: 
Antimicrobial Agents and Chemotherapy

Artemether-lumefantrine (AL), dihydroartemisinin-piperaquine (DP), and amodiaquine-sulfadoxine-pyrimethamine (AQ-SP) offer excellent antimalarial efficacy but may select for parasite polymorphisms that decrease drug sensitivity. We evaluated the selection of known polymorphisms in genes encoding putative transporters (pfcrt and pfmdr1) and SP targets (pfdhfr and pfdhps) in parasites that caused new infections within 42 days of therapy for uncomplicated falciparum malaria in Burkina Faso.

Author(s): 
Somé, Anyirékun Fabrice
Séré, Yves Y.
Dokomajilar, Christian
Zongo, Issaka
Rouamba, Noel
Greenhouse, Bryan
Ouédraogo, Jean-Bosco
Rosenthal, Philip J.
Publication Title: 
Emerging Infectious Diseases

Drug resistance in malaria and in tuberculosis (TB) are major global health problems. Although the terms multidrug-resistant TB and extensively drug-resistant TB are precisely defined, the term multidrug resistance is often loosely used when discussing malaria. Recent declines in the clinical effectiveness of antimalarial drugs, including artemisinin-based combination therapy, have prompted the need to revise the definitions of and/or to recategorize antimalarial drug resistance to include extensively drug-resistant malaria.

Author(s): 
Wongsrichanalai, Chansuda
Varma, Jay K.
Juliano, Jonathan J.
Kimerling, Michael E.
MacArthur, John R.
Publication Title: 
Pharmaceutical Biology

CONTEXT: Development of resistance in human pathogens against conventional antibiotic necessitates searching indigenous medicinal plants having antibacterial property. Twenty-seven medicinal plants used actively in folklore, ayurvedic and traditional system of medicine were selected for the evaluation of their antimicrobial activity for this study. Eleven plants chosen from these 27 are used as spices in local cuisine. OBJECTIVE: Evaluation of the effectiveness of some medicinal plant extracts against clinical isolates.

Author(s): 
Ali, Nafisa Hassan
Faizi, Shaheen
Kazmi, Shahana Urooj
Publication Title: 
Indian Journal of Experimental Biology

"Triphala", the Ayurvedic wonder is used traditionally for the treatment of different types of diseases since antiquity. The hydroalcoholic extracts of the three components of Triphala powder demonstrated varying degrees of strain specific antibacterial activity against multidrug-resistant uropathogenic bacteria. Terminalia chebula fruit extract was active against all the test isolates followed by Terminalia belerica and Emblica officinalis.

Author(s): 
Bag, Anwesa
Bhattacharyya, Subir Kumar
Pal, Nishith Kumar
Publication Title: 
The Journal of Antimicrobial Chemotherapy

OBJECTIVES: The capacity to properly address the worldwide incidence of infectious diseases lies in the ability to detect, prevent and effectively treat these infections. Therefore, identifying and analysing inhibitory agents are worthwhile endeavours in an era when few new classes of effective antimicrobials have been developed.

Author(s): 
Haydel, Shelley E.
Remenih, Christine M.
Williams, Lynda B.

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