Drugs, Chinese Herbal

Publication Title: 
The American Journal of Chinese Medicine

Jiawey siwu (JS) is a modified formula of siwu with the addition of Ginseng Radix and Eucommiae Cortex. We studied the CNS effect of JS on pentobarbital-induced hypnosis in ICR mice after acute oral administration. We also investigated the motor activity and exercise performance effects of JS in SD rats after subchronic (12 days) and chronic (8 weeks) oral administration with an activity cage and rotarod, respectively. The duration of pentobarbital-induced hypnosis was significantly decreased in mice after acute oral administration of 0.21, 1.05 or 4.2 g/kg JS.

Jian, Z. H.
Chen, C. C.
Lu, H. Y.
Chu, C. P.
Ng, Y. Y.
Yu, S.
Publication Title: 
Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials

Yangyin Anshen Koufuye could obviously decrease the spontaneous activity of rats, effectively shorten the process of falling into sleep of normal rats which were injected pentobarbital sodium and prolong the sleeping time. The effect of sedation and hypnotism were the same as Zhaoren Anshen Koufuye. Yangyin Anshen Koufuye also could markedly reduce the serum tensity of T3, T4 of hyperthyroid rats, which equaled to TCM's deficiency of yin.

Zhong, J.
Wang, X.
Cui, Y.
Zhu, G.
Meng, Y.
Zhang, L.
Yuang, X.
Publication Title: 
Biological & Pharmaceutical Bulletin

The ameliorating effects of LiuWei Dihuang Wang (LDW) after single, one-week or two-week treatment of scopolamine (SCOP)-induced and p-chloroamphetamine (PCA)-induced amnesia by using the passive avoidance task and the facilitatory effects on two-way active avoidance performance in rats were studied. LDW (2 g/kg) after single treatment significantly prolonged the shortened step-through latency induced by SCOP and PCA. Then, SCOP- and PCA-induced amnesia was reversed by 1 and 0.1-1 g/kg LDW with one-week consecutive treatment respectively.

Hsieh, Ming-Tsuen
Cheng, Sung-Jen
Lin, Li-Wei
Wang, Wen-Hsin
Wu, Chi-Rei
Publication Title: 
Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials

OBJECTIVE: To study optimum ingredient of prescriptions of Gutianquan capsule. METHODS: The study was carried out with orthogonal design. The optimum ingredient were studied by anti-diuretic action on rats and sedative-hypnosis action on mice. RESULTS: The composition of Gutianquan capsules should be the best one of the original prescription of Sangpiaoxiao Pulvis. CONCLUSION: Orthogonal design can be used to study prescription of the traditional Chinese medicine.

Tang, Daoquan
Liu, Xiao
Zhao, Wei
Publication Title: 
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA

OBJECTIVE: To investigate the effect of Danhong injection on the cardiovascular, the respiratory, and the nervous systems in animals. METHODS: Using the pressure transducer, tension transducer and subcutaneous electrodes connected to a multifunctional signal processor, the femoral artery pressure, respiratory curve and electrocardiogram were recorded, respectively, in dogs before and after administration of Danhong injection. The effect of the injection on spontaneous activities was observed in mice using a multifunctional mouse activity recorder.

Tai, Ming-Hui
Liu, Lan-Mei
Ma, Ren-Qiang
Li, Xue
Pang, Jian-Xin
Xu, Jiang-Ping
Publication Title: 
Alimentary Pharmacology & Therapeutics

BACKGROUND: Complementary and alternative medical therapies and practices are widely employed in the treatment of the irritable bowel syndrome. AIM: To review the usage of complementary and alternative medicine in the irritable bowel syndrome, and to assess critically the basis and evidence for its use. METHODS: A systematic review of complementary and alternative medical therapies and practices in the irritable bowel syndrome was performed based on literature obtained through a Medline search.

Hussain, Z.
Quigley, E. M. M.
Publication Title: 
Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan

Spinosin is the major effective single constituent in the traditional Chinese herb Semen Ziziphi Spinosae, which is used for sedation and hypnosis. For the further use of spinosin in treating insomnia, the pharmacokinetics and tissue distribution of spinosin after intravenous administration to rats was investigated. An HPLC method with an ODS column (250 mm x 4.6 mm, i.d.) and a mobile phase of acetonitrile-water-acetic acid (23:77:1) was used for the determination of spinosin in the plasma and tissues of rats. Vanillin was used as an internal standard, and spinosin was detected at 334 nm.

Li, Yu-Juan
Dai, Yue-Han
Yu, Ye-Ling
Li, Yan
Deng, Yu-Lin
Publication Title: 
Canadian Family Physician Médecin De Famille Canadien

OBJECTIVE: To review the evidence supporting selected complementary and alternative medicine approaches used in the treatment of irritable bowel syndrome (IBS).

Shen, Yi-Hao A.
Nahas, Richard
Publication Title: 
Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica

OBJECTIVE: To understand the action mechanism of Tianwang Buxin decoction that is the whole prescription included all drugs from Tianwang Buxin honeyed pill and Tianwang Buxin without radix platycodi decoction on the nerves-calming and hyposomnia-curing. METHOD: The influence of Tianwang Buxin decoction and Tianwang Buxin without radix platycodi decoction on somnus utilizing the mice' s somnus in coordination with Pentobarbital sodium was observed.

Li, Haijing
Gao, Yue
Liu, Ping
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

This study investigated the effect of Danshen on the pharmacodynamic-pharmacokinetic (PD-PK) effects of midazolam, a model CYP3A probe substrate. The effects of acute and 3-day Danshen treatment on the pharmacokinetics of a low dose midazolam (10 mg/kg, i.p.) were determined in vivo in the rat. Danshen (200 mg/kg, i.p.) treatment decreased midazolam clearance by 16%, with increases in the AUC by 22% and the half-life by 14%. 3-Day Danshen treatment (200 mg/kg/day, i.p.) for 3 days decreased the clearance, with increases in the T(1/2) and AUC.

Wang, Xin
Lee, Wayne Y. W.
Zhou, Xuelin
Or, Penelope M. Y.
Yeung, John H. K.


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