Publication Title: 
Archives Des Maladies Du Coeur Et Des Vaisseaux

Born in Arles on February 21st 1875, Madame J. C. was the oldest registered human being. She died on August 4th 1997 at the age of 122 years, the record for longevity probably for a long moment. Based on this unique case and a review of the literature, the authors describe the mechanical, physiological and clinical aspects of normal cardiac ageing. The diseases of the elderly which accelerate the process of physiological ageing are then reviewed.

MÈry, D.
Veux, C.
Hiddoud, A.
Si Ahmed, S.
LËbre, V.
Publication Title: 
Aging Cell

Rapamycin has been shown to extend lifespan in numerous model organisms including mice, with the most dramatic longevity effects reported in females. However, little is known about the functional ramifications of this longevity-enhancing paradigm in mammalian tissues. We treated 24-month-old female C57BL/6J mice with rapamycin for 3†months and determined health outcomes via a variety of noninvasive measures of cardiovascular, skeletal, and metabolic health for individual mice.

Flynn, James M.
O'Leary, Monique N.
Zambataro, Christopher A.
Academia, Emmeline C.
Presley, Michael P.
Garrett, Brittany J.
Zykovich, Artem
Mooney, Sean D.
Strong, Randy
Rosen, Clifford J.
Kapahi, Pankaj
Nelson, Michael D.
Kennedy, Brian K.
Melov, Simon
Publication Title: 
Laboratory Investigation; a Journal of Technical Methods and Pathology

Cardiac hypertrophy is a common finding in human patients with inborn errors of long-chain fatty acid oxidation. Mice with either very long-chain acyl-coenzyme A dehydrogenase deficiency (VLCAD-/-) or long-chain acyl-coenzyme A dehydrogenase deficiency (LCAD-/-) develop cardiac hypertrophy. Cardiac hypertrophy, initially measured using heart/body weight ratios, was manifested most severely in LCAD-/- male mice. VLCAD-/- mice, as a group, showed a mild increase in normalized cardiac mass (8.8% hypertrophy compared with all wild-type (WT) mice).

Cox, Keith B.
Liu, Jian
Tian, Liqun
Barnes, Stephen
Yang, Qinglin
Wood, Philip A.
Publication Title: 
Laboratory Investigation; a Journal of Technical Methods and Pathology

Thymidylate kinase (TMPK) is a nucleoside monophosphate kinase that catalyzes phosphorylation of thymidine monophosphate to thymidine diphosphate. TMPK also mediates phosphorylation of monophosphates of thymidine nucleoside analog (NA) prodrugs on the pathway to their active triphosphate antiviral or antitumor moieties. Novel transgenic mice (TG) expressing human (h) TMPK were genetically engineered using the alpha-myosin heavy chain promoter to drive its cardiac-targeted overexpression.

Kohler, James J.
Hosseini, Seyed H.
Cucoranu, Ioan
Zhelyabovska, Olga
Green, Elgin
Ivey, Kristopher
Abuin, Allison
Fields, Earl
Hoying, Amy
Russ, Rodney
Santoianni, Robert
Raper, C. Michael
Yang, Qinglin
Lavie, Arnon
Lewis, William
Publication Title: 
Journal of the American College of Cardiology

OBJECTIVES: The objective of this prospective, single-site, 2-year dietary intervention study was to evaluate the effects of moderate weight reduction and subsequent partial weight regain on cardiovascular structure and function. BACKGROUND: Obesity is associated with adverse cardiac and vascular structural and functional alterations. METHODS: Sixty obese subjects (age 46 + or - 10 years, body mass index 37 + or - 3 kg/m(2)) were evaluated during their participation in a weight loss study.

de las Fuentes, Lisa
Waggoner, Alan D.
Mohammed, B. Selma
Stein, Richard I.
Miller, Bernard V.
Foster, Gary D.
Wyatt, Holly R.
Klein, Samuel
Davila-Roman, Victor G.
Publication Title: 
Cardiovascular Diabetology

BACKGROUND: In the general population, peripheral metabolic complications (MC) increase the risk for left ventricular dysfunction. Human immunodeficiency virus infection (HIV) and combination anti-retroviral therapy (cART) are associated with MC, left ventricular dysfunction, and a higher incidence of cardiovascular events than the general population. We examined whether myocardial nutrient metabolism and left ventricular dysfunction are related to one another and worse in HIV infected men treated with cART vs. HIV-negative men with or without MC.

Cade, W. Todd
Reeds, Dominic N.
Overton, E. Turner
Herrero, Pilar
Waggoner, Alan D.
Davila-Roman, Victor G.
Lassa-Claxton, Sherry
Gropler, Robert J.
Soto, Pablo F.
Krauss, Melissa J.
Yarasheski, Kevin E.
Peterson, Linda R.
Publication Title: 
Congestive Heart Failure (Greenwich, Conn.)

Although exercise is an important component of heart failure management, optimal regimens, particularly in heart failure with preserved ejection fraction (HFPEF), are uncertain. Tai chi (TC) is a mind-body exercise that may have potential benefits but has not been studied in this population. The authors randomized 16 patients with HFPEF to either 12 weeks TC or aerobic exercise. Assessments included peak oxygen uptake, 6-minute walk, quality of life, echocardiography, mood, and self-efficacy at baseline and at 12 weeks.

Yeh, Gloria Y.
Wood, Malissa J.
Wayne, Peter M.
Quilty, Mary T.
Stevenson, Lynne W.
Davis, Roger B.
Phillips, Russell S.
Forman, Daniel E.
Publication Title: 
Clinical Cardiology

There has been no report regarding therapy of extracorporeal life support (ECLS) that showed stunned myocardium echocardiographically and electrocardiographically in patients with acute myocardial infarction. ECLS was performed in eight patients with cardiogenic shock or arrest unresponsive to catecholamines and intra-aortic balloon pumping following myocardial infarction; these patients required prolonged external cardiac massage. After the initiation of ECLS, both blood pressure and metabolic acidosis improved in all patients.

Kurose, M.
Okamoto, K.
Sato, T.
Kukita, I.
Taki, K.
Goto, H.
Publication Title: 
European Journal of Cancer Care

Our aims were to investigate the immediate effect of myofascial release on heart rate variability and mood state, and the influence of attitude towards massage in breast cancer survivors with cancer-related fatigue. Twenty breast cancer survivors reporting moderate to high cancer-related fatigue participated in this crossover study. All patients presented to the laboratory at the same time of the day on two occasions separated by a 2-week interval. At each session, they received either a massage intervention or control intervention.

Fernández-Lao, C.
Cantarero-Villanueva, I.
Díaz-Rodríguez, L.
Cuesta-Vargas, A. I.
Fernández-Delas-Peñas, C.
Arroyo-Morales, M.
Publication Title: 
PloS One

BACKGROUND: Despite remarkable progress in treatment of chronic heart failure (CHF) over the last two decades, mortality, personal suffering and cost remain staggering, and effective interventions are still a challenge. Previously we reported that a blueberry-enriched diet (BD) attenuated necroapoptosis and inflammation in periinfarct area in a rat model of myocardial infarction (MI). OBJECTIVES: To test the hypothesis that BD will attenuate the course of CHF, including mortality and cardiac remodeling during the first year after induction of MI in rats.

Ahmet, Ismayil
Spangler, Edward
Shukitt-Hale, Barbara
Joseph, James A.
Ingram, Donald K.
Talan, Mark


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