Electron Transport Chain Complex Proteins

Publication Title: 
Ageing Research Reviews

Multicellular organisms are composed of an interactive network of various tissues that are functionally organized as discrete organs. If aging were slowed in a specific tissue or organ how would that impact longevity at the organismal level? In recent years, molecular genetic approaches in invertebrate model systems have dramatically improved our understanding of the aging process and have provided insight into the preceding question.

Author(s): 
Rera, Michael
Azizi, Masoud J.
Walker, David W.
Publication Title: 
Gerontology

This short review portrays the evolutionary theories of aging in the light of the existing discoveries from genomic and molecular genetic studies on aging and longevity. At the outset, an historical background for the development of the evolutionary theories of aging is presented through the works of August Weismann (programmed death and the germ plasm theories) including his exceptional theoretical postulation, later experimentally validated by the existence of cell division limits.

Author(s): 
Ljubuncic, Predrag
Reznick, Abraham Z.
Publication Title: 
Ageing Research Reviews

Multicellular organisms are composed of an interactive network of various tissues that are functionally organized as discrete organs. If aging were slowed in a specific tissue or organ how would that impact longevity at the organismal level? In recent years, molecular genetic approaches in invertebrate model systems have dramatically improved our understanding of the aging process and have provided insight into the preceding question.

Author(s): 
Rera, Michael
Azizi, Masoud J.
Walker, David W.
Publication Title: 
Neurochemical Research

To investigate the mitochondrial decay and oxidative damage resulting from aging, the activities/kinetics of the mitochondrial complexes were examined in the brains of young and old rats as well as in old rats fed R-alpha-lipoic acid plus acetyl-L-carnitine (LA/ALC). The brain mitochondria of old rats, compared with young rats, had significantly decreased endogenous antioxidants and superoxide dismutase activity; more oxidative damage to lipids and proteins; and decreased activities of complex I, IV and V. Complex I showed a decrease in binding affinity (increase in K(m)) for substrates.

Author(s): 
Long, Jiangang
Gao, Feng
Tong, Liqi
Cotman, Carl W.
Ames, Bruce N.
Liu, Jiankang
Publication Title: 
Circulation Research

RATIONALE: Caloric restriction (CR) confers cardioprotection against ischemia/reperfusion injury. However, the exact mechanism(s) underlying CR-induced cardioprotection remain(s) unknown. Recent evidence indicates that Sirtuins, NAD(+)-dependent deacetylases, regulate various favorable aspects of the CR response. Thus, we hypothesized that deacetylation of specific mitochondrial proteins during CR preserves mitochondrial function and attenuates production of reactive oxygen species during ischemia/reperfusion.

Author(s): 
Shinmura, Ken
Tamaki, Kayoko
Sano, Motoaki
Nakashima-Kamimura, Naomi
Wolf, Alexander M.
Amo, Taku
Ohta, Shigeo
Katsumata, Yoshinori
Fukuda, Keiichi
Ishiwata, Kyoko
Suematsu, Makoto
Adachi, Takeshi
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