Ellagic Acid

Publication Title: 
Journal of Food Protection

The growth-inhibitory activity of materials derived from the fruit of Terminalia chebula was evaluated against six intestinal bacteria by means of an impregnated paper disk agar diffusion method. The butanol fraction of T. chebula extract had profound growth-inhibitory activity at a concentration of 5 mg per disk. The biologically active component isolated from the T. chebula fruits was identified with a variety of spectroscopic analyses as ethanedioic acid. The growth responses varied in accordance with the bacterial strain, chemical, and dosage tested.

Author(s): 
Kim, H. G.
Cho, J. H.
Jeong, E. Y.
Lim, J. H.
Lee, S. H.
Lee, H. S.
Publication Title: 
Natural Product Communications

Abhayarishta is an Ayurvedic formulation prepared traditionally by the fermentation of the decoction of Terminalia chebula (pericarp), Vitis vinifera (fruits), Embelia ribes (fruits) and Madhuca indica (flowers). In the present communication, chemical changes occurring during fermentation in Abhayarishta have been studied for the purpose of its standardization. An HPLC-DAD method for quantitative estimation of selected marker constituents in the formulation has been developed and validated.

Author(s): 
Lal, Uma Ranjan
Tripathi, Shailendra Mani
Jachak, Sanjay M.
Bhutani, Kamlesh Kumar
Singh, Inder Pal
Publication Title: 
PloS One

BACKGROUND: Burgeoning antibiotic resistance in Pseudomonas aeruginosa has necessitated the development of anti pathogenic agents that can quench acylhomoserine lactone (AHL) mediated QS with least risk of resistance. This study explores the anti quorum sensing potential of T. chebula Retz. and identification of probable compounds(s) showing anti QS activity and the mechanism of attenuation of P. aeruginosa PAO1 virulence factors. METHODS AND RESULTS: Methanol extract of T. chebula Retz. fruit showed anti QS activity using Agrobacterium tumefaciens A136.

Author(s): 
Sarabhai, Sajal
Sharma, Prince
Capalash, Neena
Publication Title: 
PloS One

The number of fully active antibiotic options that treat nosocomial infections due to multidrug-resistant Acinetobacter baumannii (A. baumannii) is extremely limited. Magnolia officinalis, Mahonia bealei, Rabdosia rubescens, Rosa rugosa, Rubus chingii, Scutellaria baicalensis, and Terminalia chebula plant extracts were previously shown to have growth inhibitory activity against a multidrug-resistant clinical strain of A. baumannii.

Author(s): 
Miyasaki, Yoko
Rabenstein, John D.
Rhea, Joshua
Crouch, Marie-Laure
Mocek, Ulla M.
Kittell, Patricia Emmett
Morgan, Margie A.
Nichols, Wesley Stephen
Van Benschoten, M. M.
Hardy, William David
Liu, George Y.
Publication Title: 
Journal of Pharmaceutical and Biomedical Analysis

Drug discovery from complex mixture like Chinese herbs is a challenge and extensive false positives make the obtainment of specific bioactive compounds difficult. In the present study, a novel sample preparation method was proposed to rapidly reveal the specific bioactive compounds from complex mixtures using ?-glucosidase as a case. Firstly, aqueous and methanol extracts of 500 traditional Chinese medicines were carried out with the aim of finding new sources of ?-glucosidase inhibitors.

Author(s): 
Li, D. Q.
Zhao, J.
Xie, J.
Li, S. P.
Publication Title: 
Journal of Applied Microbiology

AIM: Polyphosphate kinase 1 (PPK1) plays an important role in virulence, antibiotic resistance and survival under stress conditions and, therefore, is an attractive therapeutic target to control infections caused by multiple drug resistant Pseudomonas aeruginosa. This study explores the PPK1 inhibiting activity of ellagic acid derivatives (EADs) from Terminalia chebula Retz. that could increase the susceptibility of Ps. aeruginosa to in vitro stress conditions.

Author(s): 
Sarabhai, S.
Harjai, K.
Sharma, P.
Capalash, N.
Publication Title: 
African journal of traditional, complementary, and alternative medicines: AJTCAM

BACKGROUND: Alzheimer's disease (AD) is one of the common neurodegenerative disorders among elderly. The purpose of this study was to determine the neuroprotective effect and mechanisms of action underlying the Terminalia chebula extracts and ellagic acid by using beta-amyloid25-35 (A?25-35)-induced cell toxicity in an undifferentiated pheochromocytoma (PC12) cell line. MATERIALS AND METHODS: The T. chebula extracts were prepared using the methanol, water, and 95% ethanol. Specifically, the ellagic acid was obtained in our laboratory.

Author(s): 
Shen, Yuh-Chiang
Juan, Chi-Wen
Lin, Che-San
Chen, Chien-Chih
Chang, Chia-Lin
Publication Title: 
Antimicrobial Agents and Chemotherapy

Malaria is one of the most significant causes of infectious disease in the world. The search for new antimalarial chemotherapies has become increasingly urgent due to the parasites' resistance to current drugs. Ellagic acid is a polyphenol found in various plant products. In this study, antimalarial properties of ellagic acid were explored. The results obtained have shown high activity in vitro against all Plasmodium falciparum strains whatever their levels of chloroquine and mefloquine resistance (50% inhibitory concentrations ranging from 105 to 330 nM).

Author(s): 
Soh, Patrice Njomnang
Witkowski, Benoit
Olagnier, David
Nicolau, Marie-Laure
Garcia-Alvarez, Maria-Concepcion
Berry, Antoine
Benoit-Vical, Françoise
Publication Title: 
Natural Product Communications

Abhayarishta is an Ayurvedic formulation prepared traditionally by the fermentation of the decoction of Terminalia chebula (pericarp), Vitis vinifera (fruits), Embelia ribes (fruits) and Madhuca indica (flowers). In the present communication, chemical changes occurring during fermentation in Abhayarishta have been studied for the purpose of its standardization. An HPLC-DAD method for quantitative estimation of selected marker constituents in the formulation has been developed and validated.

Author(s): 
Lal, Uma Ranjan
Tripathi, Shailendra Mani
Jachak, Sanjay M.
Bhutani, Kamlesh Kumar
Singh, Inder Pal
Publication Title: 
Diabetes

Diabetes is a major risk factor for premature atherosclerosis, and oxidative stress appears to be an important mechanism. Previously, we showed that diabetic monocytes produce increased superoxide anion (O(2)(-)), and alpha-tocopherol (AT) supplementation decreases this. The aim of this study was to elucidate the mechanism(s) of O(2)(-) release and inhibition by AT under hyperglycemic (HG) conditions in monocytes.

Author(s): 
Venugopal, Senthil Kumar
Devaraj, Sridevi
Yang, Teddy
Jialal, Ishwarlal

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