Endometriosis

Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Endometriosis is a prevalent gynaecological condition, significantly affecting women's lives. Clinical presentations may vary from absence of symptoms to complaints of chronic pelvic pain, most notably dysmenorrhoea. The management of pain in endometriosis is currently inadequate. Acupuncture has been studied in gynaecological disorders but its effectiveness for pain in endometriosis is uncertain. OBJECTIVES: To determine the effectiveness and safety of acupuncture for pain in endometriosis.

Author(s): 
Zhu, Xiaoshu
Hamilton, Kindreth D.
McNicol, Ewan D.
Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: This overview reports on interventions for pain relief and for subfertility in pre-menopausal women with clinically diagnosed endometriosis. OBJECTIVES: The objective of this overview was to summarise the evidence from Cochrane systematic reviews on treatment options for women with pain or subfertility associated with endometriosis. METHODS: Published Cochrane systematic reviews reporting pain or fertility outcomes in women with clinically diagnosed endometriosis were eligible for inclusion in the overview.

Author(s): 
Brown, Julie
Farquhar, Cindy
Publication Title: 
Journal of Stem Cells

Since Rita Levi Montalcini and Stanley Cohen received Nobel Prize for their pioneering work on nerve growth factor (NGF), its role in female reproductive system has been reinforced in last two decades. The neurotrophins (NT) including nerve growth factor (NGF) are a family of related growth factors and their respective receptor tyrosine kinases that are of major importance in the regulation of neuronal survival and differentiation.

Author(s): 
Bose, Chinmoy K.
Publication Title: 
Forschende Komplementärmedizin (2006)

BACKGROUND: 15% of patients with severe endometriosis suffer from pain symptoms in spite of pharmacological and surgical treatments. In this retrospective study we aimed to assess the effectiveness of a combined therapy of Traditional Chinese medicine and hypnotherapy (systemic autoregulation therapy, SART) as a novel treatment for endometriosis-associated symptoms. PATIENTS AND METHODS: 47 patients with severe endometriosis, which were treated with SART, were followed-up by standardized telephone interviews. Follow-up data were compared to baseline assessments.

Author(s): 
Meissner, Karin
Böhling, Barbara
Schweizer-Arau, Annemaria
Publication Title: 
Zentralblatt Für Gynäkologie

Endometriosis is one of the main illnesses affecting women during their fertile age. Symptoms caused by endometriosis include dysmenorrhea, chronic pelvic pain, dyspareunia, menstrual disorders and infertility. Apart from surgical and medical treatment, including hormonal therapies, different alternative treatments exist. Ayurveda, homeopathy, dietary considerations as well as herbal therapies can be used as supplementary treatment for complaints caused by endometriosis. This article gives an overview over these alternative treatments, which many women experience as additionally useful.

Author(s): 
Wienhard, J.
Tinneberg, H.-R.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

BACKGROUND: Chronic pelvic pain in adolescents accounts for 10% of outpatient gynecology visits, and 70% of adolescent patients whose pelvic pain is unresponsive to initial therapy have endometriosis. To date, there has been no published research investigating the use of acupuncture for adolescents with chronic pelvic pain and/or endometriosis. METHODS: This paper presents two case reports describing the impact of a course of acupuncture on adolescent girls with endometriosis-related chronic pelvic pain of more than 1 year.

Author(s): 
Highfield, Ellen Silver
Laufer, Marc R.
Schnyer, Rosa N.
Kerr, Catherine E.
Thomas, Phaedra
Wayne, Peter M.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

BACKGROUND: Very little research has been conducted in the West to evaluate the clinical efficacy of Japanese acupuncture (JA). The characteristics that define and differentiate JA from Chinese acupuncture styles add specific challenges to the operationalization of treatment protocols for use in clinical trials. OBJECTIVES: To develop an ecologically valid and viable multimodal treatment intervention, including active and sham protocols, for use in a pilot randomized sham-controlled trial of a style of JA in treating endometriosis-related chronic pelvic pain in adolescents and young women.

Author(s): 
Schnyer, Rosa N.
Iuliano, Diane
Kay, Joseph
Shields, Monica
Wayne, Peter
Publication Title: 
Journal of Pediatric and Adolescent Gynecology

STUDY OBJECTIVE: To assess feasibility, and collect preliminary data for a subsequent randomized, sham-controlled trial to evaluate Japanese-style acupuncture for reducing chronic pelvic pain and improving health-related quality of life (HRQOL) in adolescents with endometriosis. DESIGN: Randomized, sham-controlled trial. SETTINGS: Tertiary-referral hospital. PARTICIPANTS: Eighteen young women (13-22y) with laparoscopically-diagnosed endometriosis-related chronic pelvic pain. INTERVENTIONS: A Japanese style of acupuncture and a sham acupuncture control.

Author(s): 
Wayne, Peter M.
Kerr, Catherine E.
Schnyer, Rosa N.
Legedza, Anna T. R.
Savetsky-German, Jacqueline
Shields, Monica H.
Buring, Julie E.
Davis, Roger B.
Conboy, Lisa A.
Highfield, Ellen
Parton, Barbara
Thomas, Phaedra
Laufer, Marc R.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVES: To determine whether electrodermal measures at Jing-Well acupuncture points, "indicator" points located at the tips of fingers and toes are associated with clinical measures in adolescent women with chronic pelvic pain. DESIGN: The design of this study was a randomized sham-controlled trial. Analyses of electrodermal measures were based on longitudinal, multivariable analyses using generalized estimating equations. SUBJECTS AND SETTING: The subjects were 14 young women (ages 14-22) with laparoscopically diagnosed endometriosis and chronic pelvic pain.

Author(s): 
Ahn, Andrew C.
Schnyer, Rosa
Conboy, Lisa
Laufer, Marc R.
Wayne, Peter M.
Publication Title: 
Reproductive Sciences (Thousand Oaks, Calif.)

Women with endometriosis have significant emotional distress; however, the contribution of stress to the pathophysiology of this disease is unclear. We used a rat model of endometriosis to examine the effects of stress on the development of this condition and its influence on inflammatory parameters. Female Sprague-Dawley rats were subjected to swim stress for 10 consecutive days prior to the surgical induction of endometriosis by suturing uterine horn implants next to the intestinal mesentery (endo-stress).

Author(s): 
Cuevas, Marielly
Flores, Idhaliz
Thompson, Kenira J.
Ramos-Ortolaza, Dinah L.
Torres-Reveron, Annelyn
Appleyard, Caroline B.

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