Publication Title: 
Journal of Natural Products

The endophytic fungus Pestalotiopsis virgatula, derived from the plant Terminalia chebula and previously found to produce a large excess of a single metabolite when grown in the minimal M1D medium, was induced to produce a variety of unusual metabolites by growing in potato dextrose broth medium. Analysis of the fermentation medium extract was performed using an HPLC-PDA-MS-SPE-NMR hyphenated system, which led to the identification of a total of eight metabolites (1-8), six of which are new.

Kesting, Julie R.
Olsen, Lars
Staerk, Dan
Tejesvi, Mysore V.
Kini, Kukkundoor R.
Prakash, Harishchandra S.
Jaroszewski, Jerzy W.
Publication Title: 
Journal of Microbiology (Seoul, Korea)

In this study, a tropical endophytic fungus, Alternaria alternata Tche-153 was isolated from a Thai medicinal plant Terminalia chebula Rezt. The ethyl acetate extract prepared from the fermentation broth exhibited significant ketoconazole-synergistic activity against Candida albicans. Bioassay-directed fractionation of the ethyl acetate extract led to the isolation of altenusin (1), isoochracinic acid (2), and altenuic acid (3) together with 2,5-dimethyl-7-hydroxychromone (4).

Phaopongthai, Jatuporn
Wiyakrutta, Suthep
Meksuriyen, Duangdeun
Sriubolmas, Nongluksna
Suwanborirux, Khanit
Publication Title: 
PloS One

Endophytic actinobacteria colonize internal tissues of their host plants and are considered as a rich and reliable source of diverse species and functional microorganisms. In this study, endophytic actinobacterial strain YIM 63111 was isolated from surface-sterilized tissue of the medicinal plant Artemisia annua. We identified strain YIM 63111 as a member of the genus Pseudonocardia. A. annua seedlings grown under both sterile and greenhouse conditions were inoculated with strain YIM 63111. The growth of A.

Li, Jie
Zhao, Guo-Zhen
Varma, Ajit
Qin, Sheng
Xiong, Zhi
Huang, Hai-Yu
Zhu, Wen-Yong
Zhao, Li-Xing
Xu, Li-Hua
Zhang, Si
Li, Wen-Jun
Publication Title: 
Biological Research

Endophytic fungi inhabit vegetable tissues or organs, without causing them any harm. Endophytes can co-evolve with plant hosts and possess species-specific interactions. They can protect the plant from insect attacks and diseases, and are also able to produce substances of biotechnological interest. In folk medicine, the bark, roots and fruits of Sapindus saponaria is used to produce substances with anxiolytic, astringent, diuretic and expectorant properties, as well as tonics, blood depuratives and cough medicine.

García, Adriana
Rhoden, Sandro A.
Rubin Filho, Celso J.
Nakamura, Celso V.
Pamphile, João A.
Publication Title: 
Journal of Zhejiang University. Science. B

Anoectochilus formosanus, commonly known as "Jewel Orchid", is a Chinese folk medicine used to treat hypertension, diabetes, and heart disease. The existence of A. formosanus is currently threatened by habitat loss, human and animal consumption, etc. The highly potent medicinal activity of A. formosanus is due to its secondary metabolites, especially kinsenosides and flavonoids. This orchid also has a unique mycorrhizal relationship.

Zhang, Fu-sheng
Lv, Ya-li
Zhao, Yue
Guo, Shun-xing
Publication Title: 
PloS One

Traditional Chinese medicine encompasses a rich empirical knowledge of the use of plants for the treatment of disease. In addition, the microorganisms associated with medicinal plants are also of interest as the producers of the compounds responsible for the observed plant bioactivity. The present study has pioneered the use of genetic screening to assess the potential of endophytes to synthesize bioactive compounds, as indicated by the presence of non-ribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) genes.

Miller, Kristin I.
Qing, Chen
Sze, Daniel Man Yuen
Neilan, Brett A.
Publication Title: 
Journal of Zhejiang University. Science. B

Santalum album Linn. is an evergreen and hemi-parasitic tree, the heartwood-sandalwood of which was used during a long history in traditional Chinese medicine. Kuhnia rosmarinifolia Vent. is a good host for 1- or 2-year-old growing S. album. The interaction between S. album and K. rosmarinifolia is still little known. Many studies have been carried out on a number of plants for identification and diversity of endophytes. In this study, in total 25 taxa of endophytic fungi were isolated from the roots of S. album and the roots of K. rosmarinifolia.

Sun, Si-sheng
Chen, Xiao-mei
Guo, Shun-xing
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