Endoplasmic Reticulum Stress

Publication Title: 
PLoS genetics

Cells respond to accumulation of misfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR) signaling pathway. The UPR restores ER homeostasis by degrading misfolded proteins, inhibiting translation, and increasing expression of chaperones that enhance ER protein folding capacity. Although ER stress and protein aggregation have been implicated in aging, the role of UPR signaling in regulating lifespan remains unknown. Here we show that deletion of several UPR target genes significantly increases replicative lifespan in yeast.

Author(s): 
Labunskyy, Vyacheslav M.
Gerashchenko, Maxim V.
Delaney, Joe R.
Kaya, Alaattin
Kennedy, Brian K.
Kaeberlein, Matt
Gladyshev, Vadim N.
Publication Title: 
Cell

Aging entails a progressive decline in protein homeostasis, which often leads to age-related diseases. The endoplasmic reticulum (ER) is the site of protein synthesis and maturation for secreted and membrane proteins. Correct folding of ER proteins requires covalent attachment of N-linked glycan oligosaccharides. Here, we report that increased synthesis of N-glycan precursors in the hexosamine pathway improves ER protein homeostasis and extends lifespan in C. elegans.

Author(s): 
Denzel, Martin S.
Storm, Nadia J.
Gutschmidt, Aljona
Baddi, Ruth
Hinze, Yvonne
Jarosch, Ernst
Sommer, Thomas
Hoppe, Thorsten
Antebi, Adam
Publication Title: 
Cell Cycle (Georgetown, Tex.)

Aging can be viewed as a quasi-programmed phenomenon driven by the overactivation of the nutrient-sensing mTOR gerogene. mTOR-driven aging can be triggered or accelerated by a decline or loss of responsiveness to activation of the energy-sensing protein AMPK, a critical gerosuppressor of mTOR.

Author(s): 
Menendez, Javier A.
Joven, Jorge
AragonËs, Gerard
BarrajÛn-Catal·n, Enrique
Beltr·n-DebÛn, Ra˙l
Borr·s-Linares, Isabel
Camps, Jordi
Corominas-Faja, Bruna
CufÌ, SÌlvia
Fern·ndez-Arroyo, Salvador
Garcia-Heredia, Anabel
Hern·ndez-Aguilera, Anna
Herranz-LÛpez, MarÌa
JimÈnez-S·nchez, Cecilia
LÛpez-Bonet, Eugeni
Lozano-S·nchez, Jes˙s
Luciano-Mateo, Fedra
Martin-Castillo, BegoÒa
Martin-Paredero, Vicente
PÈrez-S·nchez, Almudena
Oliveras-Ferraros, Cristina
Riera-Borrull, Marta
RodrÌguez-Gallego, Esther
Quirantes-PinÈ, Rosa
Rull, Anna
Tom·s-Menor, Laura
Vazquez-Martin, Alejandro
Alonso-Villaverde, Carlos
Micol, Vicente
Segura-Carretero, Antonio
Publication Title: 
PLoS genetics

Cells respond to accumulation of misfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR) signaling pathway. The UPR restores ER homeostasis by degrading misfolded proteins, inhibiting translation, and increasing expression of chaperones that enhance ER protein folding capacity. Although ER stress and protein aggregation have been implicated in aging, the role of UPR signaling in regulating lifespan remains unknown. Here we show that deletion of several UPR target genes significantly increases replicative lifespan in yeast.

Author(s): 
Labunskyy, Vyacheslav M.
Gerashchenko, Maxim V.
Delaney, Joe R.
Kaya, Alaattin
Kennedy, Brian K.
Kaeberlein, Matt
Gladyshev, Vadim N.
Publication Title: 
Cell

Aging entails a progressive decline in protein homeostasis, which often leads to age-related diseases. The endoplasmic reticulum (ER) is the site of protein synthesis and maturation for secreted and membrane proteins. Correct folding of ER proteins requires covalent attachment of N-linked glycan oligosaccharides. Here, we report that increased synthesis of N-glycan precursors in the hexosamine pathway improves ER protein homeostasis and extends lifespan in C. elegans.

Author(s): 
Denzel, Martin S.
Storm, Nadia J.
Gutschmidt, Aljona
Baddi, Ruth
Hinze, Yvonne
Jarosch, Ernst
Sommer, Thomas
Hoppe, Thorsten
Antebi, Adam
Publication Title: 
Nature

The blood system is sustained by a pool of haematopoietic stem cells (HSCs) that are long-lived due to their capacity for self-renewal. A consequence of longevity is exposure to stress stimuli including reactive oxygen species (ROS), nutrient fluctuation and DNA damage. Damage that occurs within stressed HSCs must be tightly controlled to prevent either loss of function or the clonal persistence of oncogenic mutations that increase the risk of leukaemogenesis.

Author(s): 
van Galen, Peter
Kreso, Antonija
Mbong, Nathan
Kent, David G.
Fitzmaurice, Timothy
Chambers, Joseph E.
Xie, Stephanie
Laurenti, Elisa
Hermans, Karin
Eppert, Kolja
Marciniak, Stefan J.
Goodall, Jane C.
Green, Anthony R.
Wouters, Bradly G.
Wienholds, Erno
Dick, John E.
Publication Title: 
Cell Cycle (Georgetown, Tex.)

Aging can be viewed as a quasi-programmed phenomenon driven by the overactivation of the nutrient-sensing mTOR gerogene. mTOR-driven aging can be triggered or accelerated by a decline or loss of responsiveness to activation of the energy-sensing protein AMPK, a critical gerosuppressor of mTOR.

Author(s): 
Menendez, Javier A.
Joven, Jorge
AragonËs, Gerard
BarrajÛn-Catal·n, Enrique
Beltr·n-DebÛn, Ra˙l
Borr·s-Linares, Isabel
Camps, Jordi
Corominas-Faja, Bruna
CufÌ, SÌlvia
Fern·ndez-Arroyo, Salvador
Garcia-Heredia, Anabel
Hern·ndez-Aguilera, Anna
Herranz-LÛpez, MarÌa
JimÈnez-S·nchez, Cecilia
LÛpez-Bonet, Eugeni
Lozano-S·nchez, Jes˙s
Luciano-Mateo, Fedra
Martin-Castillo, BegoÒa
Martin-Paredero, Vicente
PÈrez-S·nchez, Almudena
Oliveras-Ferraros, Cristina
Riera-Borrull, Marta
RodrÌguez-Gallego, Esther
Quirantes-PinÈ, Rosa
Rull, Anna
Tom·s-Menor, Laura
Vazquez-Martin, Alejandro
Alonso-Villaverde, Carlos
Micol, Vicente
Segura-Carretero, Antonio
Publication Title: 
Tumori

AIMS AND BACKGROUND: Previous studies showed that dihydroartemisinin (DHA) possessed antitumor activity in many human tumor cells through the induction of apoptosis. The aim of this study was to investigate the effects of DHA on apoptosis in the human hepatocellular carcinoma cell line HepG2 and the possible molecular mechanisms involved. METHODS: The inhibitory effect of DHA on HepG2 cells was measured by MTT assay. The percentage of apoptotic cells was detected by flow cytometry with double staining of fluorescein isothiocyanate-annexin V/propidium iodide.

Author(s): 
Gao, Xiaoling
Luo, Ziguo
Xiang, Tingxiu
Wang, Kejian
Li, Jian
Wang, Pilong
Publication Title: 
The AAPS journal

The plants used in Ayurvedic medicine, which has been practiced in India for thousands of years for the treatment of a variety of disorders, are rich in chemicals potentially useful for prevention and treatment of cancer. Withania somnifera (commonly known as Ashwagandha in Ayurvedic medicine) is one such medicinal plant whose anticancer value was realized over four decades ago after isolation of a crystalline steroidal compound (withaferin A) from the leaves of this shrub. The root and leaf extracts of W.

Author(s): 
Vyas, Avani R.
Singh, Shivendra V.
Publication Title: 
The AAPS journal

The plants used in Ayurvedic medicine, which has been practiced in India for thousands of years for the treatment of a variety of disorders, are rich in chemicals potentially useful for prevention and treatment of cancer. Withania somnifera (commonly known as Ashwagandha in Ayurvedic medicine) is one such medicinal plant whose anticancer value was realized over four decades ago after isolation of a crystalline steroidal compound (withaferin A) from the leaves of this shrub. The root and leaf extracts of W.

Author(s): 
Vyas, Avani R.
Singh, Shivendra V.

Pages

Subscribe to RSS - Endoplasmic Reticulum Stress