Endothelium

Publication Title: 
Homeopathy: The Journal of the Faculty of Homeopathy

Hahnemann considered the secondary action of medicines to be a law of nature and reviewed the conditions under which it occurs. It is closely related to the rebound effects observed with many modern drugs. I review the evidence of the rebound effect of statins that support the similitude principle. In view of their indications in primary and secondary prevention of cardiovascular diseases, statins are widely prescribed.

Author(s): 
Teixeira, Marcus Zulian
Publication Title: 
Current Opinion in Clinical Nutrition and Metabolic Care

PURPOSE OF REVIEW: The purpose of this review is to highlight recent publications examining nitric oxide production in health and disease and its association with clinical nutrition and alterations in metabolism. RECENT FINDINGS: The role of the cofactor tetrahydrobiopterin in nitric oxide production and its relation with arginine availability is indicated as an important explanation for the arginine paradox. This offers potential for nitric oxide regulation by dietary factors such as arginine or its precursors and vitamin C.

Author(s): 
Luiking, Yvette C.
Engelen, MariÎlle P. K. J.
Deutz, Nicolaas E. P.
Publication Title: 
Atherosclerosis

OBJECTIVE: Offspring of patients with type 2 diabetes (OPDs) exhibits endothelial dysfunction (ED) associated with a chronic inflammatory state. N-3 polyunsaturated fatty acids (n-3 PUFA) may have antioxidant and anti-inflammatory properties that are beneficial for cardiovascular and metabolic health. Therefore, in the present study, we tested the hypothesis that dietary supplementation with fish oil rich in n-3 PUFA may improve ED in otherwise healthy OPDs. METHODS AND DESIGN: A double-blind, placebo-controlled trial was conducted with 50 OPDs.

Author(s): 
Rizza, Stefano
Tesauro, Manfredi
Cardillo, Carmine
Galli, Angelica
Iantorno, Micaela
Gigli, Fabrizio
Sbraccia, Paolo
Federici, Massimo
Quon, Michael J.
Lauro, Davide
Publication Title: 
Atherosclerosis

Large clinical trials demonstrate that control of blood pressure or hyperlipidemia reduces risk for cardiovascular events by approximately 30%. Factors that may further reduce remaining risk are not definitively established. One potential target is atherosclerosis, a crucial feature in the pathogenesis of cardiovascular diseases whose development is determined by multiple mechanism including complex interactions between endothelial dysfunction and insulin resistance.

Author(s): 
Koh, Kwang Kon
Han, Seung Hwan
Oh, Pyung Chun
Shin, Eak Kyun
Quon, Michael J.
Publication Title: 
Biochemistry

Vascular adhesion molecules regulate the migration of leukocytes from the blood into tissue during inflammation. Binding of leukocytes to vascular cell adhesion molecule-1 (VCAM-1) activates signals in endothelial cells, including Rac1 and calcium fluxes. These VCAM-1 signals are required for leukocyte transendothelial migration on VCAM-1. However, it has not been reported whether the cytoplasmic domain of VCAM-1 is necessary for these signals.

Author(s): 
Marchese, Michelle E.
Berdnikovs, Sergejs
Cook-Mills, Joan M.
Publication Title: 
Obesity (Silver Spring, Md.)

OBJECTIVE: The effect of weight loss on obesity-associated endothelial dysfunction is not clear because of conflicting data, demonstrating both improvement and no change in endothelial function after weight loss in obese subjects. A 2-year prospective study (n = 121) was conducted to examine: (1) the effect of obesity and weight loss (either a low-carbohydrate or and low-fat diet) on flow mediated vasodilatation (FMD), a measure of endothelial function.

Author(s): 
Mohler, Emile R.
Sibley, Alexandra A.
Stein, Richard
Davila-Roman, Victor
Wyatt, Holly
Badellino, Karen
Rader, Daniel J.
Klein, Samuel
Foster, Gary D.
Publication Title: 
Homeopathy: The Journal of the Faculty of Homeopathy

Hahnemann considered the secondary action of medicines to be a law of nature and reviewed the conditions under which it occurs. It is closely related to the rebound effects observed with many modern drugs. I review the evidence of the rebound effect of statins that support the similitude principle. In view of their indications in primary and secondary prevention of cardiovascular diseases, statins are widely prescribed.

Author(s): 
Teixeira, Marcus Zulian
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