Enhancer of Zeste Homolog 2 Protein

Publication Title: 
Psychiatric Genetics

OBJECTIVES: Anxiety is associated with elevated levels of the inflammatory cytokine interleukin-6 (IL-6) and an increased risk for diseases with an inflammatory aetiology. In cancer, higher levels of IL-6 have been associated with increased expression of the epigenetic enzymes DNMT1 and Enhancer of Zeste Homolog 2 (EZH2). However, the relationship between IL-6 and DNA methyltransferases (DNMTs) and EZH2 expression has not previously been examined in anxious individuals.

Author(s): 
Murphy, Therese M.
O'Donovan, Aoife
Mullins, Niamh
O'Farrelly, Cliona
McCann, Amanda
Malone, Kevin
Publication Title: 
Nature Neuroscience

Brain-derived neurotrophic factor (BDNF) has a crucial role in modulating neural and behavioral plasticity to drugs of abuse. We found a persistent downregulation of exon-specific Bdnf expression in the ventral tegmental area (VTA) in response to chronic opiate exposure, which was mediated by specific epigenetic modifications at the corresponding Bdnf gene promoters.

Author(s): 
Koo, Ja Wook
Mazei-Robison, Michelle S.
LaPlant, Quincey
Egervari, Gabor
Braunscheidel, Kevin M.
Adank, Danielle N.
Ferguson, Deveroux
Feng, Jian
Sun, HaoSheng
Scobie, Kimberly N.
Damez-Werno, Diane M.
Ribeiro, Efrain
PeÒa, Catherine Jensen
Walker, Deena
Bagot, Rosemary C.
Cahill, Michael E.
Anderson, Sarah Ann R.
LabontÈ, Benoit
Hodes, Georgia E.
Browne, Heidi
Chadwick, Benjamin
Robison, Alfred J.
Vialou, Vincent F.
Dias, Caroline
Lorsch, Zachary
Mouzon, Ezekiell
Lobo, Mary Kay
Dietz, David M.
Russo, Scott J.
Neve, Rachael L.
Hurd, Yasmin L.
Nestler, Eric J.
Publication Title: 
The International Journal of Neuropsychopharmacology

BACKGROUND: The human Val66Met polymorphism in brain-derived neurotrophic factor (BDNF), a key factor in neuroplasticity, synaptic function, and cognition, has been implicated in the pathophysiology of neuropsychiatric and neurodegenerative disorders. BDNF is encoded by multiple transcripts with distinct regulation and localization, but the impact of the Val66Met polymorphism on BDNF regulation remains unclear.

Author(s): 
Mallei, Alessandra
Baj, Gabriele
Ieraci, Alessandro
Corna, Stefano
Musazzi, Laura
Lee, Francis S.
Tongiorgi, Enrico
Popoli, Maurizio
Publication Title: 
Journal of Biomolecular Screening

Long non-protein coding RNAs (lncRNAs) are an important class of molecules that help orchestrate key cellular events. Although their functional roles in cells are not well understood, thousands of lncRNAs and a number of possible mechanisms by which they act have been reported. LncRNAs can exert their regulatory function in cells by interacting with epigenetic enzymes. In this study, we developed a tool to study lncRNA-protein interactions for high-throughput screening of small-molecule modulators using AlphaScreen technology.

Author(s): 
Pedram Fatemi, Roya
Salah-Uddin, Sultan
Modarresi, Farzaneh
Khoury, Nathalie
Wahlestedt, Claes
Faghihi, Mohammad Ali
Publication Title: 
PloS One

Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder resulting from expansion of CAG repeats in the Huntingtin (HTT) gene. Previous studies have shown mutant HTT can alter expression of genes associated with dysregulated epigenetic modifications. One of the most widely studied chromatin modifications is trimethylated lysine 4 of histone 3 (H3K4me3).

Author(s): 
Dong, Xianjun
Tsuji, Junko
Labadorf, Adam
Roussos, Panos
Chen, Jiang-Fan
Myers, Richard H.
Akbarian, Schahram
Weng, Zhiping
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