Publication Title: 
Aging Cell

Cellular senescence is a defense mechanism in response to molecular damage which accumulates with aging. Correspondingly, the number of senescent cells has been reported to be greater in older than in younger subjects and furthermore associates with age-related pathologies. Inter-individual differences exist in the rate at which a person ages (biological age). Here, we studied whether younger biological age is related to fewer senescent cells in middle-aged individuals with the propensity for longevity, using p16INK4a as a marker for cellular senescence.

Waaijer, MariÎtte E. C.
Parish, William E.
Strongitharm, Barbara H.
van Heemst, Diana
Slagboom, Pieternella E.
de Craen, Anton J. M.
Sedivy, John M.
Westendorp, Rudi G. J.
Gunn, David A.
Maier, Andrea B.
Publication Title: 
Journal of Cosmetic Dermatology

INTRODUCTION: Imedeenô is a cosmeceutical that provides nutrients to the skin. One of its active ingredients is the Marine Complexô (MC). AIM: The aim of this study was to evaluate whether MC affects skin morphogenesis differently in female and male human skin equivalents (HSEs). METHODS: Human skin equivalents were established with cells obtained from female or male donors between 30 and 45 years of age and cultured for seven or 11 weeks in the presence or absence of MC.

Rietveld, Marion
Janson, David
Siamari, Rachida
Vicanova, Jana
Andersen, Maja Troest
El Ghalbzouri, Abdoelwaheb
Publication Title: 
Developmental Cell

Developmental timing genes catalyze stem cell progression and animal maturation programs across taxa. Caenorhabditis elegans DRE-1/FBXO11 functions in an SCF E3-ubiquitin ligase complex to regulate the transition to adult programs, but its cognate proteolytic substrates are unknown. Here, we identify the conserved transcription factor BLMP-1 as a substrate of the SCF(DRE-1/FBXO11) complex. blmp-1 deletion suppressed dre-1 mutant phenotypes and exhibited developmental timing defects opposite to dre-1.

Horn, Moritz
Geisen, Christoph
Cermak, Lukas
Becker, Ben
Nakamura, Shuhei
Klein, Corinna
Pagano, Michele
Antebi, Adam
Publication Title: 
Investigational New Drugs

Recent research suggests that altered redox control of melanoma cell survival, proliferation, and invasiveness represents a chemical vulnerability that can be targeted by pharmacological modulation of cellular oxidative stress. The endoperoxide artemisinin and semisynthetic artemisinin-derivatives including dihydroartemisinin (DHA) constitute a major class of antimalarials that kill plasmodium parasites through induction of iron-dependent oxidative stress.

Cabello, Christopher M.
Lamore, Sarah D.
Bair, Warner B.
Qiao, Shuxi
Azimian, Sara
Lesson, Jessica L.
Wondrak, Georg T.
Publication Title: 
International Journal of Molecular Medicine

We previously reported that PMI-5011, an ethanolic extract of Artemisia dracunculus L., alleviates peripheral neuropathy in high fat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and pro-inflammatory changes in the peripheral nervous system. This study evaluated PMI-5011 on established functional, structural, and biochemical changes associated with Type I diabetic peripheral neuropathy.

Watcho, Pierre
Stavniichuk, Roman
Tane, Pierre
Shevalye, Hanna
Maksimchyk, Yury
Pacher, Pal
Obrosova, Irina G.
Publication Title: 
The Journal of Biological Chemistry

Retinoic acid is essential for skin growth and differentiation, and its concentration in skin is controlled tightly. In humans, four different members of the short-chain dehydrogenase/reductase (SDR) superfamily of proteins were proposed to catalyze the rate-limiting step in the biosynthesis of retinoic acid (the oxidation of retinol to retinaldehyde). Epidermis contains at least three of these enzymes, but their relative importance for retinoic acid biosynthesis and regulation of gene expression during growth and differentiation of epidermis is not known.

Lee, Seung-Ah
Belyaeva, Olga V.
Wu, Lizhi
Kedishvili, Natalia Y.
Publication Title: 
Photochemistry and Photobiology

There is considerable interest in the identification of natural agents capable of affording protection to skin from the adverse effects of solar ultraviolet B (UVB) radiation. Pomegranate (Punica granatum L.) fruit possesses as strong antioxidant, anti-inflammatory and antiproliferative properties. Recently, we have shown that oral feeding of pomegranate fruit extract (PFE) to mice afforded substantial protection from the adverse effects of single UVB radiation via modulation in early biomarkers of photocarcinogenesis.

Khan, Naghma
Syed, Deeba N.
Pal, Harish Chandra
Mukhtar, Hasan
Afaq, Farrukh
Publication Title: 
Experimental Dermatology

Delphinidin (Del), [3,5,7,3'-,4'-,5'-hexahydroxyflavylium], an anthocyanidin and a potent antioxidant abundantly found in pigmented fruits and vegetables exhibits proapoptotic effects in many cancer cells. Here, we determined the effect of Del on growth, apoptosis and differentiation of normal human epidermal keratinocytes (NHEKs) in vitro in submerged cultures and examined its effects in a three-dimensional (3D) epidermal equivalent (EE) model that permits complete differentiation reminiscent of in vivo skin.

Chamcheu, Jean Christopher
Afaq, Farrukh
Syed, Deeba N.
Siddiqui, Imtiaz A.
Adhami, Vaqar M.
Khan, Naghma
Singh, Sohinderjit
Boylan, Brendan T.
Wood, Gary S.
Mukhtar, Hasan
Publication Title: 
Acta Paediatrica (Oslo, Norway: 1992)

Topical therapy to enhance skin barrier function may be a simple, low-cost, effective strategy to improve outcome of preterm infants with a developmentally compromised epidermal barrier, as lipid constituents of topical products may act as a mechanical barrier and augment synthesis of barrier lipids. Natural oils are applied topically as part of a traditional oil massage to neonates in many developing countries. We sought to identify inexpensive, safe, vegetable oils available in developing countries that improved epidermal barrier function.

Darmstadt, G. L.
Mao-Qiang, M.
Chi, E.
Saha, S. K.
Ziboh, V. A.
Black, R. E.
Santosham, M.
Elias, P. M.
Publication Title: 
The Journal of Investigative Dermatology

A heavy water ((2)H(2)O) labeling method recently developed to measure cell proliferation in vivo is applied here to the measurement of murine epidermal cell turnover and to investigate conditions in which keratinocyte proliferation is either inhibited or stimulated. The technique is based on incorporation of (2)H(2)O into the deoxyribose moiety of deoxyribonucleotides in dividing cells. Label incorporation and die-away studies in cells isolated from C57BL/6J mouse epidermis revealed the replacement rate to be 34%-44% per wk (half-life of 1.6-2 wk).

Hsieh, Elaine A.
Chai, Christine M.
de Lumen, Benito O.
Neese, Richard A.
Hellerstein, Marc K.


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