Ergosterol

Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVE: Isolation of biologically active fractions and compounds from the roots of Withania somnifera, a plant used extensively as a constituent of rasayana, in Ayurveda and to test their adaptogenic activity on stress indices using the cold-hypoxia-restraint (C-H-R) model. DESIGN: Bioactivity-guided fractionation of an aqueous extract of the roots of Withania somnifera led to the isolation of a new species of withanolide 1-oxo-5beta, 6beta-epoxy-witha-2-ene-27-ethoxy-olide.

Author(s): 
Kaur, Parvinder
Sharma, Meenakshi
Mathur, Sheenu
Tiwari, Manisha
Divekar, Harish M.
Kumar, Ratan
Srivastava, Kaushal K.
Chandra, Ramesh
Publication Title: 
Molecular Cancer Therapeutics

The plant Withania somnifera Dunal (Ashwagandha), also known as Indian ginseng, is widely used in the Ayurvedic system of medicine to treat tumors, inflammation, arthritis, asthma, and hypertension. Chemical investigation of the roots and leaves of this plant has yielded bioactive withanolides. Earlier studies showed that withanolides inhibit cyclooxygenase enzymes, lipid peroxidation, and proliferation of tumor cells.

Author(s): 
Ichikawa, Haruyo
Takada, Yasunari
Shishodia, Shishir
Jayaprakasam, Bolleddula
Nair, Muraleedharan G.
Aggarwal, Bharat B.
Publication Title: 
Chemical & Pharmaceutical Bulletin

Multiple shoot cultures of two experimental lines of Withania somnifera plants (RS-Selection-1 and RS-Selection-2) were established using nodal segments as explants. The hormonal combinations of benzyl adenine and kinetin not only influenced their morphogenetic response but also differentially modulated the level of biogeneration of withanolide A in the in vitro shoots of the two lines. Interestingly, withanolide-A, that was hardly detectable in the aerial parts of field-grown Withania somnifera (explant source), accumulated considerably in the in vitro shoot cultures of the plant.

Author(s): 
Sangwan, Rajender Singh
Chaurasiya, Narayan Das
Lal, Payare
Misra, Laxminarain
Uniyal, Girish Chandra
Tuli, Rakesh
Sangwan, Neelam Singh
Publication Title: 
Journal of Translational Medicine

Ayurveda is one of the ancient systems of health care of Indian origin. Roughly translated into "Knowledge of life", it is based on the use of natural herbs and herb products for therapeutic measures to boost physical, mental, social and spiritual harmony and improve quality of life. Although sheltered with long history and high trust, ayurveda principles have not entered laboratories and only a handful of studies have identified pure components and molecular pathways for its life-enhancing effects.

Author(s): 
Deocaris, Custer C.
Widodo, Nashi
Wadhwa, Renu
Kaul, Sunil C.
Publication Title: 
Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan

Ashwagandha (root of Withania somnifera) has been used for many purposes, it is mainly considered a tonic in traditional Ayurvedic medicine. This review focuses on the effects of compounds isolated from Ashwagandha on dementia models and on the spinal cord injury model. Our study demonstrated that the active constituents, withanolide A, withanoside IV, and withanoside VI, restored presynapses and postsynapses, in addition to both axons and dendrites in cortical neurons after Abeta(25-35)-induced injury.

Author(s): 
Tohda, Chihiro
Publication Title: 
Cancer Research

Withaferin A (WA) is derived from the medicinal plant Withania somnifera, which has been safely used for centuries in Indian Ayurvedic medicine for treatment of different ailments. We now show, for the first time, that WA exhibits significant activity against human breast cancer cells in culture and in vivo. The WA treatment decreased viability of MCF-7 (estrogen-responsive) and MDA-MB-231 (estrogen-independent) human breast cancer cells in a concentration-dependent manner.

Author(s): 
Stan, Silvia D.
Hahm, Eun-Ryeong
Warin, Renaud
Singh, Shivendra V.
Publication Title: 
Nutrition and Cancer

Withaferin A (WA) is derived from the medicinal plant Withania somnifera that has been safely used for centuries in the Indian Ayurvedic medicine for treatment of various ailments. We now demonstrate that WA treatment causes G2 and mitotic arrest in human breast cancer cells.

Author(s): 
Stan, Silvia D.
Zeng, Yan
Singh, Shivendra V.
Publication Title: 
BMC genomics

BACKGROUND: Nuclear Factor kappa B (NF-κB) is a transcription factor involved in the regulation of cell signaling responses and is a key regulator of cellular processes involved in the immune response, differentiation, cell proliferation, and apoptosis. The constitutive activation of NF-κB contributes to multiple cellular outcomes and pathophysiological conditions such as rheumatoid arthritis, asthma, inflammatory bowel disease, AIDS and cancer. Thus there lies a huge therapeutic potential beneath inhibition of NF-κB signalling pathway for reducing these chronic ailments.

Author(s): 
Grover, Abhinav
Shandilya, Ashutosh
Punetha, Ankita
Bisaria, Virendra S.
Sundar, Durai
Publication Title: 
Indian Journal of Experimental Biology

Antioxidant activity of active principles of Withania somnifera, consisting of equimolar concentrations of sitoindosides VII-X and withaferin A, was investigated for their effects on rat brain frontal cortical and striatal concentrations of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX). Results were compared with effects induced by deprenyl, an agent with well documented antioxidant activity. Active glycowithanolides of W.

Author(s): 
Bhattacharya, S. K.
Satyan, K. S.
Ghosal, S.
Publication Title: 
Phytotherapy research: PTR

Glycowithanolides, consisting of equimolar concentrations of sitoindosides VII-X and withaferin A, isolated from the roots of Withania somnifera Dunal, have been reported to have an antioxidant effect in the rat brain frontal cortex and striatum. In the present study, the effect of 10 days of oral administration of these active principles, in graded doses (10, 20 and 50 mg/kg), was noted on iron overload (FeSo(4), 30 mg/kg, i.p.) induced hepatotoxicity in rats.

Author(s): 
Bhattacharya, A.
Ramanathan, M.
Ghosal, S.
Bhattacharya, S. K.

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