Erythroid Cells

Publication Title: 
International Journal of Hematology

FKHRL1 is one of the human homologues of DAF-16, which is concerned with longevity in Caenorhabditis elegans. Previously, we demonstrated that FKHRL1 functions downstream of Akt in erythropoietin (EPO) signaling and that it is directly phosphorylated by activated Akt. Because phosphorylated FKHRL1 loses its transcriptional activity and translocates into the cytoplasm, FKHRL1 appears to be nonfunctional in the presence of EPO.

Author(s): 
Uchida, Mie
Kirito, Keita
Endo, Hitoshi
Ozawa, Keiya
Komatsu, Norio
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