Estrogens

Publication Title: 
Journal of the Neurological Sciences

Amyotrophic lateral sclerosis (ALS) is a progressive disease which is caused by degeneration of motor neurons in the central nervous system. The incidence of ALS is higher in men than women, but the female advantage disappears with increased age. Here, we report evidence that the female advantage is due to the protective role of estrogen. In an ALS mouse model carrying the human Cu/Zn superoxide dismutase (hSOD1) G93A transgene, ovariectomy did not alter the onset age of the disease while reducing the female lifespan by 7 days and making it comparable to that of the male transgenic mice.

Author(s): 
Choi, Chan-Il
Lee, Young-Don
Gwag, Byoung Joo
Cho, Sung Ig
Kim, Sung-Soo
Suh-Kim, Haeyoung
Publication Title: 
Best Practice & Research. Clinical Endocrinology & Metabolism

Sex differences in lifespan exist world-wide, with women outliving men by more than a decade in some countries. The gender gap is not a uniquely human phenomenon; most sexually reproducing species examined show sex differences in patterns of ageing, yet a comprehensive explanation does not exist. Here, we discuss how ageing responds to natural selection on traits that arise as a consequence of sexuality.

Author(s): 
Regan, Jennifer C.
Partridge, Linda
Publication Title: 
Best Practice & Research. Clinical Endocrinology & Metabolism

Sex differences in lifespan exist world-wide, with women outliving men by more than a decade in some countries. The gender gap is not a uniquely human phenomenon; most sexually reproducing species examined show sex differences in patterns of ageing, yet a comprehensive explanation does not exist. Here, we discuss how ageing responds to natural selection on traits that arise as a consequence of sexuality.

Author(s): 
Regan, Jennifer C.
Partridge, Linda
Publication Title: 
Experimental Gerontology
Author(s): 
Everitt, A. V.
Publication Title: 
Cancer Treatment and Research
Author(s): 
Cobleigh, M. A.
Publication Title: 
Nutrition in Clinical Practice: Official Publication of the American Society for Parenteral and Enteral Nutrition

BACKGROUND: Breast cancer is the most commonly diagnosed cancer among women in the United States. Extensive research has been completed to evaluate the relationship between dietary factors and breast cancer risk and survival after breast cancer; however, a summary report with clinical inference is needed. Materials and METHODS: This review summarizes the current epidemiological and clinical trial evidence relating diet to breast cancer incidence, recurrence, survival, and mortality.

Author(s): 
Thomson, Cynthia A.
Publication Title: 
Brain Research

Longer duration of reproductive years of life and thus greater exposure to endogenous estrogen may be associated with a lower risk of age-related diseases in women. The present study examined the relationship between estimated endogenous estrogen exposure and telomere length (TL) and telomerase activity, two biomarkers of cellular aging, in a sample of postmenopausal women at risk for cognitive decline. Telomere length was measured using a quantitative PCR method and telomerase activity by TRAP (Telomere-Repeats Amplification Protocol) assay in peripheral blood mononuclear cells (PBMCs).

Author(s): 
Lin, Jue
Kroenke, Candyce H.
Epel, Elissa
Kenna, Heather A.
Wolkowitz, Owen M.
Blackburn, Elizabeth
Rasgon, Natalie L.
Publication Title: 
Lancet
Author(s): 
Blackburn, E. K.
Publication Title: 
British Medical Journal
Author(s): 
Blackburn, E. K.
Publication Title: 
Brain Research

Longer duration of reproductive years of life and thus greater exposure to endogenous estrogen may be associated with a lower risk of age-related diseases in women. The present study examined the relationship between estimated endogenous estrogen exposure and telomere length (TL) and telomerase activity, two biomarkers of cellular aging, in a sample of postmenopausal women at risk for cognitive decline. Telomere length was measured using a quantitative PCR method and telomerase activity by TRAP (Telomere-Repeats Amplification Protocol) assay in peripheral blood mononuclear cells (PBMCs).

Author(s): 
Lin, Jue
Kroenke, Candyce H.
Epel, Elissa
Kenna, Heather A.
Wolkowitz, Owen M.
Blackburn, Elizabeth
Rasgon, Natalie L.

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