Ethiopia

Publication Title: 
Explore (New York, N.Y.)

In searching for different patterns of practice, lifestyle, and environment supportive of optimal health, we look to our elders around the world, who in the wisdom that has sustained them, we learn from with careful attention. Thirty-seven elders who live by their traditions participated in the present study. They assisted in the refinement of the methodology and collections and preparation of these data. These participants are well-respected, representative elders and traditional healers of their regions.

Author(s): 
Pesek, Todd
Reminick, Ronald
Nair, Murali
Publication Title: 
Tropical and Geographical Medicine
Author(s): 
Giel, R.
Publication Title: 
Malaria Journal

BACKGROUND: Due to increasing drug resistance, artemisinin-based combination chemotherapy (ACT) has become the first-line treatment of falciparum malaria in many endemic countries. However, irreversible ototoxicity associated with artemether/lumefantrine (AL) has been reported recently and suggested to be a serious limitation in the use of ACT. The aim of the study was to compare ototoxicity, tolerability, and efficacy of ACT with that of quinine and atovaquone/proguanil in the treatment of uncomplicated falciparum malaria.

Author(s): 
Gürkov, Robert
Eshetu, Teferi
Miranda, Isabel Barreto
Berens-Riha, Nicole
Mamo, Yoseph
Girma, Tsinuel
Krause, Eike
Schmidt, Michael
Hempel, John-Martin
Löscher, Thomas
Publication Title: 
Malaria Journal

BACKGROUND: An increasing number of malaria-endemic African countries are rapidly scaling up malaria prevention and treatment. To have an initial estimate of the impact of these efforts, time trends in health facility records were evaluated in selected districts in Ethiopia and Rwanda, where long-lasting insecticidal nets (LLIN) and artemisinin-based combination therapy (ACT) had been distributed nationwide by 2007. METHODS: In Ethiopia, a stratified convenience sample covered four major regions where (moderately) endemic malaria occurs.

Author(s): 
Otten, Mac
Aregawi, Maru
Were, Wilson
Karema, Corine
Medin, Ambachew
Bekele, Worku
Jima, Daddi
Gausi, Khoti
Komatsu, Ryuichi
Korenromp, Eline
Low-Beer, Daniel
Grabowsky, Mark
Publication Title: 
Tropical medicine & international health: TM & IH

OBJECTIVE: To assess the impact and feasibility of artemether-lumefantrine deployment at community level, combined with phased introduction of rapid diagnostic tests (RDTs), on malaria transmission, morbidity, and mortality and health service use in a remote area of Ethiopia. METHODS: Two-year pilot study in two districts: artemether-lumefantrine was prescribed after parasitological confirmation of malaria in health facilities in both districts.

Author(s): 
Lemma, Hailemariam
Byass, Peter
Desta, Alem
Bosman, Andrea
Costanzo, Gianfranco
Toma, Luigi
Fottrell, Edward
Marrast, Anne-Claire
Ambachew, Yohannes
Getachew, Asefaw
Mulure, Nathan
Morrone, Aldo
Bianchi, Angela
Barnabas, Gebre Ab
Publication Title: 
Malaria Journal

BACKGROUND: In 2005, a nationwide survey estimated that 6.5% of households in Ethiopia owned an insecticide-treated net (ITN), 17% of households had been sprayed with insecticide, and 4% of children under five years of age with a fever were taking an anti-malarial drug.

Author(s): 
Jima, Daddi
Getachew, Asefaw
Bilak, Hana
Steketee, Richard W.
Emerson, Paul M.
Graves, Patricia M.
Gebre, Teshome
Reithinger, Richard
Hwang, Jimee
Ethiopia Malaria Indicator Survey Working Group
Publication Title: 
PloS One

BACKGROUND: In 2005, the Ministry of Health in Ethiopia launched a major effort to distribute over 20 million long-lasting insecticidal nets, provide universal access to artemisinin-based combination therapy (ACTs), and train 30,000 village-based health extension workers. METHODS AND FINDINGS: A cross-sectional, nationally representative Malaria Indicator Survey was conducted during the malaria transmission season in 2007. Multivariate logistic regression analyses were performed to assess the effect of women's malaria knowledge on household ITN ownership and women's ITN use.

Author(s): 
Hwang, Jimee
Graves, Patricia M.
Jima, Daddi
Reithinger, Richard
Kachur, S. Patrick
Ethiopia MIS Working Group
Publication Title: 
Malaria Journal

BACKGROUND: The emergence of drug resistance is a major problem in malaria control. Combination of molecular genotyping and characterization of mutations or single nucleotide polymorphisms (SNPs) correlated with drug resistance can provide information for subsequent surveillance of existing and developing drug resistance patterns. The introduction of artemether/lumefantrine (AL) as first-line treatment, never used before in Ethiopia, allowed the collection of baseline data of molecular polymorphisms before a selection due to AL could occur.

Author(s): 
Eshetu, Teferi
Berens-Riha, Nicole
Fekadu, Sintayehu
Tadesse, Zelalem
Gürkov, Robert
Hölscher, Michael
Löscher, Thomas
Miranda, Isabel Barreto
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

Chloroquine (CQ) is still the drug of choice for the treatment of vivax malaria in Ethiopia, whereas artemether-lumefantrine (AL) is for falciparum malaria. In this setting, clinical malaria cases are treated with AL. This necessitated the need to assess the effectiveness of AL for the treatment of Plasmodium vivax with CQ as a comparator. A total of 57 (80.3%) and 75 (85.2%) cases treated with CQ or AL, respectively, completed the study in an outpatient setting.

Author(s): 
Yohannes, Ambachew M.
Teklehaimanot, Awash
Bergqvist, Yngve
Ringwald, Pascal
Publication Title: 
Malaria Journal

BACKGROUND: In vivo efficacy assessments of the first-line treatments for Plasmodium falciparum malaria are essential for ensuring effective case management. In Ethiopia, artemether-lumefantrine (AL) has been the first-line treatment for uncomplicated P. falciparum malaria since 2004. METHODS: Between October and November 2009, we conducted a 42-day, single arm, open label study of AL for P. falciparum in individuals >6 months of age at two sites in Oromia State, Ethiopia. Eligible patients who had documented P.

Author(s): 
Hwang, Jimee
Alemayehu, Bereket H.
Hoos, David
Melaku, Zenebe
Tekleyohannes, Samuel G.
Teshi, Takele
Birhanu, Sintayehu G.
Demeke, Leykun
Gobena, Kedir
Kassa, Moges
Jima, Daddi
Reithinger, Richard
Nettey, Henry
Green, Michael
Malone, Joseph L.
Kachur, S. Patrick
Filler, Scott

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