Ethosuximide

Publication Title: 
PLoS genetics

Ethosuximide is a medication used to treat seizure disorders in humans, and we previously demonstrated that ethosuximide can delay age-related changes and extend the lifespan of the nematode Caenorhabditis elegans. The mechanism of action of ethosuximide in lifespan extension is unknown, and elucidating how ethosuximide functions is important for defining endogenous processes that influence lifespan and for exploring the potential of ethosuximide as a therapeutic for age-related diseases.

Author(s): 
Collins, James J.
Evason, Kimberley
Pickett, Christopher L.
Schneider, Daniel L.
Kornfeld, Kerry
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