Eukaryotic Initiation Factors

Publication Title: 
Aging Cell

Dietary restriction (DR) results in a robust increase in lifespan while maintaining the physiology of much younger animals in a wide range of species. Here, we examine the role of drr-2, a DR-responsive gene recently identified, in determining the longevity of Caenorhabditis elegans. Inhibition of drr-2 has been shown to increase longevity. However, the molecular mechanisms by which drr-2 influences longevity remain unknown.

Author(s): 
Ching, Tsui-Ting
Paal, Alisha B.
Mehta, Avni
Zhong, Linda
Hsu, Ao-Lin
Publication Title: 
Arthritis and Rheumatism

OBJECTIVE: Aberrant posttranscriptional regulation of matrix metalloproteinases (MMPs) by microRNA has emerged as an important factor in human diseases. The aim of this study was to determine whether the expression of MMP-13 in human osteoarthritis (OA) chondrocytes is regulated by microRNA. METHODS: Chondrocytes were stimulated with interleukin-1beta (IL-1beta) in vitro. Total RNA was prepared using TRIzol reagent. Polymerase chain reaction (PCR)-based arrays were used to determine the expression profile of 352 human microRNA.

Author(s): 
Akhtar, Nahid
Rasheed, Zafar
Ramamurthy, Sangeetha
Anbazhagan, Arivarasu N.
Voss, Frank R.
Haqqi, Tariq M.
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