Euphorbia

Publication Title: 
Planta Medica

The bioassay-directed isolation of Terminalia chebula fruits afforded four human immunodeficiency virus type 1 (HIV-1) integrase inhibitors, gallic acid ( 1) and three galloyl glucoses ( 2 - 4). In addition, four flavonol glycoside gallates ( 5 - 8) from Euphorbia pekinensis containing the galloyl moiety also showed the inhibitory activity at a level comparable to those of 2 - 4.

Author(s): 
Ahn, Mi-Jeong
Kim, Chul Young
Lee, Ji Suk
Kim, Tae Gyun
Kim, Seung Hee
Lee, Chong-Kyo
Lee, Bo-Bin
Shin, Cha-Gyun
Huh, Hoon
Kim, Jinwoong
Publication Title: 
Indian Journal of Experimental Biology

The leaf extract of E. neriifolia significantly reduced apomorphine-induced stereotypy in mice at all doses (100, 200, 400 mg/kg body weight) in mice and rats and was devoid of catalepsic effect thereby, suggesting specific dopaminergic receptor modulating activity. The extract (400 mg/kg) potentiated pentobarbitone-induced hypnosis. It showed protection against maximal electro-shock-induced convulsion at 400 mg/kg. E. neriifolia leaf extract had anxiolytic action at 400 mg/kg by increasing the percentage of time spent in open arm in elevated plus-maze.

Author(s): 
Bigoniya, Papiya
Rana, A. C.
Publication Title: 
Anticancer Research

BACKGROUND: A search for inhibitors of multidrug resistance (MDR)-associated protein 1 (MRP1) was performed among the compounds isolated from Euphorbia species, plants traditionally used in folk medicine. MATERIALS AND METHODS: Fifteen compounds with terpenic or phenolic structures (macrocyclic and polycyclic diterpenes, coumarins, stilbenes and flavonoids) were isolated from the methanol extracts of Euphorbia lagascae and Euphorbia tuckeyana or obtained by derivatization.

Author(s): 
Wesolowska, Olga
Wisniewski, Jerzy
Duarte, Noélia
Ferreira, Maria-José U.
Michalak, Krystyna
Publication Title: 
Molecules (Basel, Switzerland)

Euphorbia species are widely distributed plants, many of which are used in folk medicine. Over the past twenty years, they have received considerable phytochemical and biological attention. Their diterpenoid constituents, especially those with abietane, tigliane, ingenane skeletons, are thought to be the main toxicant and bioactive factors. In this work, the utility of (13)C-NMR spectroscopy for the structural elucidation of these compounds is briefly discussed.

Author(s): 
Wu, Qi-Cheng
Tang, Yu-Ping
Ding, An-Wei
You, Fen-Qiang
Zhang, Li
Duan, Jin-Ao
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To study the antihyperglycemic and antinociceptive activities of methanolic extract of the whole plant of Euphorbia thymifolia L., a plant used in folk medicine of Bangladesh for treatment of diabetes and pain. METHODS: Antihyperglycemic activity studies were conducted in glucose-loaded mice by oral glucose tolerance tests. Mice were given various doses of the extract, followed by glucose (2 g/kg body weight), 1 h after administration of the extract. Serum glucose levels were measured 2 h after glucose administration.

Author(s): 
Rahmatullah, Mohammed
Hasan, Sumaiyah Kanij
Ali, Zulfiquar
Rahman, Shahnaz
Jahan, Rownak
Publication Title: 
Molecules (Basel, Switzerland)

The roots of Euphorbia kansui are considered an important traditional folk medicine. In this study the ethanol extracts of E. kansui were investigated. A new tetracyclic triterpenoid, euphane-3b,20-dihydroxy-24-ene, in addition to five known triterpenoids with euphane skeletons were isolated. Their structures were elucidated on the basis of physical and spectral techniques (1D-, 2D-NMR and MS, respectively).

Author(s): 
Guo, Jie
Zhou, Li-Yan
He, Hong-Ping
Leng, Ying
Yang, Zhen
Hao, Xiao-Jiang
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