European Continental Ancestry Group

Publication Title: 
European journal of human genetics: EJHG

The 11p15.5 chromosomal region (2.8 Mb) is of particular interest as it encloses five genes (HRAS1, SIRT3, TH, INS and IGF2), the variability of which was found to be associated with life extension by association studies. Mostly important, the above genes are homologous of genes that modulate lifespan in model organisms. We scanned the area in four European sample groups for a total of 1321 centenarians and 1140 younger subjects, who shared with centenarians ethnicity and geographical origin, with a set of 239 SNPs.

Author(s): 
Lescai, Francesco
BlanchÈ, HÈlËne
Nebel, Almut
Beekman, Marian
Sahbatou, Mourad
Flachsbart, Friederike
Slagboom, Eline
Schreiber, Stefan
Sorbi, Sandro
Passarino, Giuseppe
Franceschi, Claudio
Publication Title: 
Clinical Cardiology

BACKGROUND: Asian Indian women have a higher rate of coronary artery disease (CAD) than do other ethnic groups, despite similar conventional risk factors and lipid profiles. Smaller high-density lipoprotein cholesterol (HDL-C) particle size is associated with reduced cardiac protection or even an increased risk of CAD. Exceptional longevity correlates better with larger HDL-C particle sizes.

Author(s): 
Bhalodkar, Narendra C.
Blum, Steve
Rana, Thakor
Kitchappa, Radha
Bhalodkar, Ami N.
Enas, Enas A.
Publication Title: 
Biogerontology

The exceptional longevity of centenarians is due in part to inherited genetic factors, as deduced from data that show that first degree relatives of centenarians live longer and have reduced overall mortality. In recent years, a number of groups have performed genetic association studies on long-living individuals (LLI) and young controls to identify alleles that are either positively or negatively selected in the centenarian population as consequence of a demographic pressure. Many of the reported studies have shown genetic loci associated with longevity.

Author(s): 
Novelli, Valeria
Viviani Anselmi, Chiara
Roncarati, Roberta
Guffanti, Guia
Malovini, Alberto
Piluso, Giulio
Puca, Annibale Alessandro
Publication Title: 
Molecular Psychiatry

General intelligence is a robust predictor of important life outcomes, including educational and occupational attainment, successfully managing everyday life situations, good health and longevity. Some neuronal correlates of intelligence have been discovered, mainly indicating that larger cortices in widespread parieto-frontal brain networks and efficient neuronal information processing support higher intelligence. However, there is a lack of established associations between general intelligence and any basic structural brain parameters that have a clear functional meaning.

Author(s): 
Penke, L.
Maniega, S. MuÒoz
Bastin, M. E.
ValdÈs Hern·ndez, M. C.
Murray, C.
Royle, N. A.
Starr, J. M.
Wardlaw, J. M.
Deary, I. J.
Publication Title: 
Prion

The PRNP gene encodes the cellular isoform of prion protein (PrP (c) ). The M129V polymorphism influences the risk of prion diseases and may modulate the rate of neurodegeneration with age. We present the first study of the polymorphism among Polish centenarians. In the control group (n = 165, ages 18 to 56 years) the observed M129V genotype frequencies agreed with those expected according to the Hardy-Weinberg equilibrium (MM, MV, VV): 43%, 44%, 13% (HWE p > 0.05).

Author(s): 
Golanska, Ewa
Sieruta, Monika
Corder, Elizabeth
Gresner, Sylwia M.
Pfeffer, Anna
Chodakowska-Zebrowska, Malgorzata
Sobow, Tomasz M.
Klich, Izabela
Mossakowska, Malgorzata
Szybinska, Aleksandra
Barcikowska, Maria
Liberski, Pawel P.
Publication Title: 
Experimental Gerontology

BACKGROUND: Telomerase, encoded by TERT, is the ribonucleoprotein polymerase that maintains telomere ends and it plays a crucial role in cellular senescence. TERT single nucleotide polymorphisms (SNPs) have been associated both with various malignancies and telomere length (TL). The association of TERT SNPs with longevity remains uncertain and varies with ethnicity. The aim of this study was to investigate whether the functional variable number of tandem repeat (VNTR) MNS16A of TERT is associated with longevity.

Author(s): 
Concetti, Fabio
Lucarini, Nazzareno
Carpi, Francesco M.
Di Pietro, Fabio
Dato, Serena
Capitani, Melania
Nabissi, Massimo
Santoni, Giorgio
Mignini, Fiorenzo
Passarino, Giuseppe
Napolioni, Valerio
Publication Title: 
PloS One

Leukocyte telomere length (LTL) and rate of telomere shortening are known biomarkers of aging while, numerous studies showed that Mediterranean diet (MD) may boost longevity. We studied association between telomere length, telomerase activity and different adherence to MD and its effects on healthy status. The study was conducted in 217 elderly subjects stratified according Mediterranean diet score (MDS) in low adherence (MDS?3), medium adherence (MDS 4-5) and high adherence (MDS?6) groups.

Author(s): 
Boccardi, Virginia
Esposito, Antonietta
Rizzo, Maria Rosaria
Marfella, Raffaele
Barbieri, Michelangela
Paolisso, Giuseppe
Publication Title: 
Metabolism: Clinical and Experimental

Our specific aim in a 10-year prospective study of 772 Cincinnati firemen (predominantly aged 26 to 46 years) was to determine the prevalence, attributes, and etiology of persistent hypobetalipoproteinemia, defined by entry low-density lipoprotein cholesterol (LDLC) less than 75 mg/dL. A second specific aim was to cross-sectionally assess hypocholesterolemia (defined by total serum cholesterol [TC] < 130 mg/dL) in 1,314 white and 165 black men aged 26 to 46 years in the National Health and Nutrition Examination Survey (NHANES I).

Author(s): 
Glueck, C. J.
Kelley, W.
Gupta, A.
Fontaine, R. N.
Wang, P.
Gartside, P. S.
Publication Title: 
Age and Ageing

BACKGROUND: being unmarried is associated with worse health and increased mortality risk. Telomere length has emerged as a marker for biological ageing but it is unclear how telomere length relates to marital status. OBJECTIVE: to examine the relationship between telomere length and marital status in a sample of middle-aged adults. Design and subjects: cross-sectional analysis among 321 adults aged 40-64 years. METHODS: telomere length was measured by PCR (T/S ratio).

Author(s): 
Mainous, Arch G.
Everett, Charles J.
Diaz, Vanessa A.
Baker, Richard
Mangino, Massimo
Codd, Veryan
Samani, Nilesh J.
Publication Title: 
The American Journal of Clinical Nutrition

BACKGROUND: In 2007, the World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) issued recommendations on diet, physical activity, and weight management for cancer prevention on the basis of the most comprehensive collection of available evidence. OBJECTIVE: We investigated whether concordance with WCRF/AICR recommendations is related to risk of death. DESIGN: The current study included 378,864 participants from 9 European countries enrolled in the European Prospective Investigation into Cancer and Nutrition study.

Author(s): 
Vergnaud, Anne-Claire
Romaguera, Dora
Peeters, Petra H.
van Gils, Carla H.
Chan, Doris S. M.
Romieu, Isabelle
Freisling, Heinz
Ferrari, Pietro
Clavel-Chapelon, FranÁoise
Fagherazzi, Guy
Dartois, Laureen
Li, Kuanrong
Tikk, Kaja
Bergmann, Manuela M.
Boeing, Heiner
Tj¯nneland, Anne
Olsen, Anja
Overvad, Kim
Dahm, Christina C.
Redondo, Maria Luisa
Agudo, Antonio
S·nchez, MarÌa-JosÈ
Amiano, Pilar
Chirlaque, MarÌa-Dolores
Ardanaz, Eva
Khaw, Kay-Tee
Wareham, Nick J.
Crowe, Francesca
Trichopoulou, Antonia
Orfanos, Philippos
Trichopoulos, Dimitrios
Masala, Giovanna
Sieri, Sabina
Tumino, Rosario
Vineis, Paolo
Panico, Salvatore
Bueno-de-Mesquita, H. Bas
Ros, Martine M.
May, Anne
Wirf‰lt, Elisabet
Sonestedt, Emily
Johansson, Ingegerd
Hallmans, Gˆran
Lund, Eiliv
Weiderpass, Elisabete
Parr, Christine L.
Riboli, Elio
Norat, Teresa

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