Evoked Potentials, Motor

Publication Title: 
PloS One

BACKGROUND: Mutation in the ubiquitously expressed cytoplasmic superoxide dismutase (SOD1) causes an inherited form of Amyotrophic Lateral Sclerosis (ALS). Mutant synthesis in motor neurons drives disease onset and early disease progression. Previous experimental studies have shown that spinal grafting of human fetal spinal neural stem cells (hNSCs) into the lumbar spinal cord of SOD1(G93A) rats leads to a moderate therapeutical effect as evidenced by local ?-motoneuron sparing and extension of lifespan.

Author(s): 
Hefferan, Michael P.
Galik, Jan
Kakinohana, Osamu
Sekerkova, Gabriela
Santucci, Camila
Marsala, Silvia
Navarro, Roman
Hruska-Plochan, Marian
Johe, Karl
Feldman, Eva
Cleveland, Don W.
Marsala, Martin
Publication Title: 
Neuroscience Research

Hypnosis often leads people to obey a suggestion of movement and to lose perceived voluntariness. This inexplicable phenomenon suggests that the state of the motor system may be altered by hypnosis; however, objective evidence for this is still lacking. Thus, we used transcranial magnetic stimulation of the primary motor cortex (M1) to investigate how hypnosis, and a concurrent suggestion that increased motivation for a force exertion task, influenced the state of the motor system.

Author(s): 
Takarada, Yudai
Nozaki, Daichi
Publication Title: 
Movement Disorders: Official Journal of the Movement Disorder Society

Our previous studies in Parkinson's disease have shown that both levodopa and expectancy of receiving levodopa reduce cortical excitability. We designed this study to evaluate how degree of expectancy and other individual factors modulate placebo response in Parkinson's patients. Twenty-six Parkinson's patients were randomized to 1 of 3 groups: 0%, 50%, and 100% expectancy of receiving levodopa. All subjects received placebo regardless of expectancy group. Subjects completed the NEO-Five Factor Inventory, General Perceived Self-Efficacy Scale, and Perceived Stress Scale.

Author(s): 
Lou, Jau-Shin
Dimitrova, Diana M.
Hammerschlag, Richard
Nutt, John
Hunt, Elizabeth A.
Eaton, Ryan W.
Johnson, Sarah C.
Davis, Melanie D.
Arnold, Grace C.
Andrea, Sarah B.
Oken, Barry S.
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

BACKGROUND: The physiologic mechanism by which spinal manipulation may reduce pain and muscular spasm is not fully understood. One such mechanistic theory proposed is that spinal manipulation may intervene in the cycle of pain and spasm by affecting the resting excitability of the motoneuron pool in the spinal cord. Previous data from our laboratory indicate that spinal manipulation leads to attenuation of the excitability of the motor neuron pool when assessed by means of peripheral nerve Ia-afferent stimulation (Hoffmann reflex).

Author(s): 
Dishman, J. Donald
Ball, Kevin A.
Burke, Jeanmarie
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

BACKGROUND: The physiologic mechanism by which spinal manipulation may reduce pain and muscular spasm is not fully understood. One such mechanistic theory proposed is that spinal manipulation may intervene in the cycle of pain and spasm by affecting the resting excitability of the motoneuron pool in the spinal cord. Previous data from our laboratory indicate that spinal manipulation leads to attenuation of the excitability of the motor neuron pool when assessed by means of peripheral nerve Ia-afferent stimulation (Hoffmann reflex).

Author(s): 
Dishman, J. Donald
Ball, Kevin A.
Burke, Jeanmarie
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

OBJECTIVE: This study investigates changes in the intrinsic inhibitory and facilitatory interactions within the sensorimotor cortex subsequent to a single session of cervical spine manipulation using single- and paired-pulse transcranial magnetic stimulation protocols. METHOD: Twelve subjects with a history of reoccurring neck pain participated in this study.

Author(s): 
Taylor, Heidi Haavik
Murphy, Bernadette
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

OBJECTIVE: The purpose of this study was to determine if high-velocity, low-amplitude spinal manipulation (SM) altered the effects of corticospinal excitability on motoneuron activity innervating the paraspinal muscles. In a previous study using transcranial magnetic stimulation (TMS), augmentation of motor-evoked potentials (MEPs) from the gastrocnemius muscle after lumbar SM was reported. To date, there is no known report of the effect of SM on paraspinal muscle excitability.

Author(s): 
Dishman, J. Donald
Greco, Douglas S.
Burke, Jeanmarie R.
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To investigate the effects of electro-acupuncture at Shuigou (DU26) on latency and amplitude of motor evoked potential (MEP) in rats after cerebral infarction. METHODS: Fifty healthy male Wistar rats were randomly divided into five groups as normal group, untreated group, sham-operated group, non-acupoint group and Shuigou group, with 10 rats in each group. By using a modification of the technique of middle cerebral artery occlusion, focal cerebral ischemia injury was induced in rats except normal and sham-operated groups. Rats in the normal group received no treatment.

Author(s): 
Yao, Wen-Ping
Wang, Shu
Han, Lin
Ma, Jin-Quan
Shen, Yan
Publication Title: 
Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan / Sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine

OBJECTIVE: To investigate the effects of different frequencies of electro-acupuncture at Shuigou (GV 26) on the latent period and wave amplitude of motor evoked potentials (MEPs) in rats with focal cerebral infarction. METHODS: Fifty healthy male Wistar rats were randomly divided into five groups: controls, model, 2 Hz Shuigou, 50 Hz Shuigou and 100 Hz Shuigou. There were 10 rats in each group. Using a modification of a technique for middle cerebral artery occlusion, focal cerebral ischemic injury was induced in all rats except those in the control group.

Author(s): 
Yao, Wen-Ping
Wang, Shu
Han, Lin
Ma, Jin-Quan
Shen, Yan
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