Publication Title: 
Current Drug Targets

Many patients in the ICU receive mechanical ventilation and require sedative medications. Anxiolysis, hypnosis, and amnesia can be considered the primary objects of sedative therapy. Intravenous benzodiazepines are the drugs most commonly used for sedation in ICU. Proper choice and use of benzodiazepines is based on knowledge of the pharmacology and is an essential component of caring for patients in the intensive care unit. Three benzodiazepines--Diazepam, Lorazepam and Midazolam--are currently available for parenteral use in the ICU.

Arcangeli, Andrea
Antonelli, Massimo
Mignani, Vittorio
Sandroni, Claudio
Publication Title: 
International Journal of Pharmaceutics

Artemether (AM) plus azithromycin (AZ) rectal co-formulations were studied to provide pre-referral treatment for children with severe febrile illnesses in malaria-endemic areas. The target profile required that such product should be cheap, easy to administer by non-medically qualified persons, rapidly effective against both malaria and bacterial infections. Analytical and pharmacotechnical development, followed by in vitro and in vivo evaluation, were conducted for various AMAZ coformulations.

Gaubert, Alexandra
Kauss, Tina
Marchivie, Mathieu
Ba, Boubakar B.
Lembege, Martine
Fawaz, Fawaz
Boiron, Jean-Michel
Lafarge, Xavier
Lindegardh, Niklas
Fabre, Jean-Louis
White, Nicholas J.
Olliaro, Piero L.
Millet, Pascal
Grislain, Luc
Gaudin, Karen
Publication Title: 
Acta Poloniae Pharmaceutica

Artemisinin (ARMN) is a potent antimalarial drug, which is effective against multidrug resistant strains of Plasmodium falciparum and produces rapid recovery even in patients with cerebral malaria. Being poorly soluble in water, artemisinin is incompletely absorbed after oral intake due to poor dissolution characteristics in the intestinal fluids. To enhance these properties, solid dispersions of artemisinin with succinic acid (SUC) were prepared using drug-carrier ratios 1 : 1, 1 : 4, 1 : 6, 1 : 8 and 1 : 10 by solvent evaporation and freeze drying methods.

Ansari, Muhammad Tayyab
Pervez, Humayun
Shehzad, Muhammad Tariq
Saeed-ul-Hassan, Syed
Mehmood, Zahid
Shah, Syed Nisar Hussain
Razi, Muhammad Tahir
Murtaza, Ghulam
Publication Title: 
Die Pharmazie

Essential oils are ingredients of cosmetic and health care products as well as massage oil used in aromatherapy. There is no doubt that essential oils and their components are able to permeate human skin. But information is rare dealing with percutanous absorption of essential oils in more detail. In this paper we investigated the in vitro skin permeation of monoterpenes and phenylpropanoids applied in pure rose oil and in form of neat single substances. We found that the application form had an exceeding influence on the skin permeation behaviour of the compounds.

Schmitt, S.
Schaefer, U.
Sporer, F.
Reichling, J.
Publication Title: 
Chemical & Pharmaceutical Bulletin

This research investigated the effects of control release of binders that are used in the pills of Chinese herbal medicine, namely, as processed honey, starch paste, beeswax, or mixtures thereof. Aspirin and baicalin were used as the active pharmaceutical ingredients (API). The processed honey was heated to 110 degrees C, 120 degrees C, or 130 degrees C. In these pills, the binders were the only excipients. The pills were prepared by the stir method using a mixer at 80 degrees C without pressure.

Yang, Zhijun
Wong, Chi Sun
Yang, Chun
Jiang, Zhi-Hong
Zhao, Zhongzhen
Liu, Liang
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