Extracellular Matrix

Publication Title: 
Journal of Cellular Biochemistry

Homo sapiens longevity assurance homologue 2 of yeast LAG1 (LASS2), also known as tumor metastasis suppressor gene 1 (TMSG1), is a newly found tumor metastasis suppressor gene in 1999. Preliminary studies showed that it not only suppressed tumor growth but also closely related to tumor metastasis, however, its molecular mechanisms is still unclear.

Author(s): 
Xu, Xiaoyan
You, Jiangfeng
Pei, Fei
Publication Title: 
Journal of Cardiovascular Translational Research

The extracellular matrix (ECM) provides structural support by serving as a scaffold for cells, and as such the ECM maintains normal tissue homeostasis and mediates the repair response following injury. In response to myocardial infarction (MI), ECM expression is generally upregulated in the left ventricle (LV), which regulates LV remodeling by modulating scar formation. The ECM directly affects scar formation by regulating growth factor release and cell adhesion and indirectly affects scar formation by regulating the inflammatory, angiogenic, and fibroblast responses.

Author(s): 
Ma, Yonggang
Halade, Ganesh V.
Lindsey, Merry L.
Publication Title: 
Progress in Molecular Biology and Translational Science

Memory is central to our ability to perform daily life activities and correctly function in society. Improvements in public health and medical treatment for a variety of diseases have resulted in longer life spans; however, age-related memory impairments have been significant sources of morbidity. Loss in memory function is not only associated with aging population but is also a feature of neurodegenerative diseases such as Alzheimer's disease and other psychiatric and neurological disorders.

Author(s): 
Khan, Zafar U.
MartÌn-MontaÒez, Elisa
Navarro-Lobato, Irene
Muly, E. Chris
Publication Title: 
Journal of Bodywork and Movement Therapies

The living matrix is defined as the continuous molecular fabric of the organism, consisting of fascia, the other connective tissues, extracellular matrices, integrins, cytoskeletons, nuclear matrices and DNA. The extracellular, cellular and nuclear biopolymers or ground substances constitute a body-wide reservoir of charge that can maintain electrical homeostasis and "inflammatory preparedness" throughout the organism.

Author(s): 
Oschman, James L.
Publication Title: 
Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology / Edited by the Gaetano Conte Academy for the Study of Striated Muscle Diseases

Muscular dystrophies such as Duchenne muscular dystrophy (DMD) are usually approached as dysfunctions of the affected skeletal myofibres and their force transmission. Comparatively little attention has been given to the increase in connective tissue (fibrosis) which accompanies these muscular changes. Interestingly, an increase in endomysial tissue is apparent long before any muscular degeneration can be observed. Fibrosis is the result of a reactive or reparative process involving mechanical, humoral and cellular factors.

Author(s): 
Klingler, Werner
Jurkat-Rott, Karin
Lehmann-Horn, Frank
Schleip, Robert
Publication Title: 
Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology / Edited by the Gaetano Conte Academy for the Study of Striated Muscle Diseases

Muscular dystrophies such as Duchenne muscular dystrophy (DMD) are usually approached as dysfunctions of the affected skeletal myofibres and their force transmission. Comparatively little attention has been given to the increase in connective tissue (fibrosis) which accompanies these muscular changes. Interestingly, an increase in endomysial tissue is apparent long before any muscular degeneration can be observed. Fibrosis is the result of a reactive or reparative process involving mechanical, humoral and cellular factors.

Author(s): 
Klingler, Werner
Jurkat-Rott, Karin
Lehmann-Horn, Frank
Schleip, Robert
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Two VLA proteins (or beta 1 integrins; originally called very late activation antigens) that bind to distinct determinants on fibronectin (FN) are increased on activated immune or memory T cells. VLA-4 binds to the peptide sequence Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (GPEILDVPST in single-letter code) on the alternatively spliced CS-1 form of FN, whereas VLA-5 binds to an Arg-Gly-Asp sequence found on all forms of FN.

Author(s): 
Ferguson, T. A.
Mizutani, H.
Kupper, T. S.
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

Chronic neutrophilic inflammation is a manifestation of a variety of lung diseases including cystic fibrosis (CF). There is increasing evidence that fragments of extracellular matrix proteins, such as collagen and elastin, play an important role in inflammatory cell recruitment to the lung in animal models of airway inflammation. Unfortunately, the association of these peptides with human disease and the identification of therapeutic targets directed toward these inflammatory pathways have remained elusive.

Author(s): 
Gaggar, Amit
Jackson, Patricia L.
Noerager, Brett D.
O'Reilly, Philip J.
McQuaid, D. Brent
Rowe, Steven M.
Clancy, J. P.
Blalock, J. Edwin
Publication Title: 
Journal of Molecular and Cellular Cardiology

In diabetes mellitus, alterations in cardiac structure/function in the absence of ischemic heart disease, hypertension or other cardiac pathologies are termed diabetic cardiomyopathy. In the United States, the prevalence of diabetes mellitus continues to rise and the disease currently affects about 8% of the general population. Hence, the use of appropriate diagnostic strategies for diabetic cardiomyopathy, which may help correctly identify the disease at early stages and implement suitable corrective therapies is imperative.

Author(s): 
Maya, Lisandro
Villarreal, Francisco J.
Publication Title: 
Breast Cancer Research and Treatment

Breast cancer (BC) is the most common malignancy of women in the developed world. To better understand its pathogenesis, knowledge of normal breast development is crucial, as BC is the result of disregulation of physiologic processes. The aim of this study was to investigate the impact of reproductive life stages on the transcriptional profile of the mammary gland in a primate model.

Author(s): 
Stute, Petra
Sielker, Sonja
Wood, Charles E.
Register, Thomas C.
Lees, Cynthia J.
Dewi, Fitriya N.
Williams, J. Koudy
Wagner, Janice D.
Stefenelli, Ulrich
Cline, J. Mark

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