False Negative Reactions

Publication Title: 
The American Journal of Tropical Medicine and Hygiene

We evaluated the ICT Malaria P.f./P.v. immunochromatographic test for the detection of the panmalarial antigen (PMA) using a rodent malaria model. Mice were infected with Plasmodium berghei by mosquito bite, and blood was examined by microscopy and the ICT test. Treatment with artemether was started when the parasite density exceeded 70,000/microL. The ICT PMA band appeared when the parasite density was more than 2,000/microL, but it continued to be positive after the parasitemia became negative in response to the drug treatment.

Author(s): 
Arai, Meiji
Ishii, Akira
Matsuoka, Hiroyuki
Publication Title: 
Malaria Journal

BACKGROUND: Malaria during pregnancy results in adverse outcomes for mothers and infants. Intermittent preventive treatment (IPT) with sulphadoxine-pyrimethamine (SP) is the primary intervention aimed at reducing malaria infection during pregnancy. Although submicroscopic infection is common during pregnancy and at delivery, its impact throughout pregnancy on the development of placental malaria and adverse pregnancy outcomes has not been clearly established.

Author(s): 
Cohee, Lauren M.
Kalilani-Phiri, Linda
Boudova, Sarah
Joshi, Sudhaunshu
Mukadam, Rabia
Seydel, Karl B.
Mawindo, Patricia
Thesing, Phillip
Kamiza, Steve
Makwakwa, Kingsley
Muehlenbachs, Atis
Taylor, Terrie E.
Laufer, Miriam K.
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

OBJECTIVE: This report reviews the case of a missed cervical spine fracture in a patient presenting for chiropractic manipulative therapy. A review of the literature suggests that radiographic examinations performed in emergency care settings following cervical spine trauma are often incomplete for the purposes of screening for contraindications to manipulative therapy.

Author(s): 
Crowther, E. R.
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

OBJECTIVE: To review the case of a patient who suffered a cervical spine fracture-dislocation missed at a hospital emergency department. CLINICAL FEATURES: A 77-year-old man involved in a motor vehicle accident was transported to a local emergency hospital where cervical spine x-ray films taken were reported as demonstrating no evidence of acute injury. The patient visited a chiropractic clinic 6 days later, where x-ray films were again obtained, finding that the patient sustained fractures of C5 and C6, as well as a bilateral facet dislocation at C5/C6.

Author(s): 
King, Steven W.
Hosler, Bryan K.
King, Mark A.
Eiselt, Eric W.
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

OBJECTIVES: The purpose of this study is to present 2 clinical case studies in which large herniated disks were not detected on magnetic resonance imaging (MRI), leading to false negative results, and discuss some issues regarding potential shortcomings of MRI. CLINICAL FEATURES: Cases of cervical and lumbar herniated nucleus pulposus (HNP) are presented. Each patient had severe pain and neurological deficit. The patients had positive physical examination findings suggestive of HNP despite the negative MRI scans.

Author(s): 
Schneider, Michael
Santolin, Steven
Farrell, Patrick
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

OBJECTIVE: To review the case of a patient who suffered a cervical spine fracture-dislocation missed at a hospital emergency department. CLINICAL FEATURES: A 77-year-old man involved in a motor vehicle accident was transported to a local emergency hospital where cervical spine x-ray films taken were reported as demonstrating no evidence of acute injury. The patient visited a chiropractic clinic 6 days later, where x-ray films were again obtained, finding that the patient sustained fractures of C5 and C6, as well as a bilateral facet dislocation at C5/C6.

Author(s): 
King, Steven W.
Hosler, Bryan K.
King, Mark A.
Eiselt, Eric W.
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

OBJECTIVES: The purpose of this study is to present 2 clinical case studies in which large herniated disks were not detected on magnetic resonance imaging (MRI), leading to false negative results, and discuss some issues regarding potential shortcomings of MRI. CLINICAL FEATURES: Cases of cervical and lumbar herniated nucleus pulposus (HNP) are presented. Each patient had severe pain and neurological deficit. The patients had positive physical examination findings suggestive of HNP despite the negative MRI scans.

Author(s): 
Schneider, Michael
Santolin, Steven
Farrell, Patrick
Publication Title: 
American Journal of Clinical Pathology

Dan Shen, a traditional Chinese medicine used in the management of cardiovascular diseases, is now available without prescription in the United States from Chinese herbal stores. We demonstrated digoxin-like immunoreactivity of Dan Shen in vitro. Because Dan Shen is used to treat cardiovascular disease, we studied potential interference of Dan Shen with serum digoxin measurement.

Author(s): 
Wahed, A.
Dasgupta, A.
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