Fanconi Anemia Complementation Group D2 Protein

Publication Title: 
Radiation Research

FancD2 plays a central role in the human Fanconi anemia DNA damage response (DDR) pathway. Fancd2(-/-) mice exhibit many features of human Fanconi anemia including cellular DNA repair defects. Whether the DNA repair defect in Fancd2(-/-) mice results in radiologic changes in all cell lineages is unknown. We measured stress of hematopoiesis in long-term marrow cultures and radiosensitivity in clonogenic survival curves, as well as comet tail intensity, total antioxidant stores and radiation-induced gene expression in hematopoietic progenitor compared to bone marrow stromal cell lines.

Berhane, Hebist
Epperly, Michael W.
Goff, Julie
Kalash, Ronny
Cao, Shaonan
Franicola, Darcy
Zhang, Xichen
Shields, Donna
Houghton, Frank
Wang, Hong
Wipf, Peter
Parmar, Kalindi
Greenberger, Joel S.
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