Publication Title: 
Diabetes & Metabolic Syndrome

STATEMENT OF THE PROBLEM: Complementary and alternative medicines have been increasingly used as a co adjuvant treatment of chronic diseases, including diabetes mellitus. However, very little is known, especially in western countries, about its effects in the treatment of type 2 diabetes mellitus (T2DM). The purpose of this review was to summarize and critically evaluate clinical evidences regarding the effect of Chinese therapeutic exercises (Qigong) in the treatment of T2DM.

Freire, Marcos Dantas Moraes
Alves, Cresio
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVES: The aim of this study was to implement fasting therapy in an inpatient integrative medicine ward and to evaluate safety, acceptance, and effects on health-related outcomes and lifestyle adherence. DESIGN: This was a prospective observational study with consecutive inpatients over 3 [corrected] years. Inclusion and exclusion criteria for fasting therapy were checked by treating physicians and recommendations given. After receiving full information patients decided whether they would participate in fasting.

Michalsen, Andreas
Hoffmann, Barbara
Moebus, Susanne
Bäcker, Markus
Langhorst, Jost
Dobos, Gustav J.
Publication Title: 
PloS One

Calorie restriction (CR) produces several health benefits and increases lifespan in many species. Studies suggest that alternate-day fasting (ADF) and exercise can also provide these benefits. Whether CR results in lifespan extension in humans is not known and a direct investigation is not feasible. However, phenotypes observed in CR animals when compared to ad libitum fed (AL) animals, including increased stress resistance and changes in protein expression, can be simulated in cells cultured with media supplemented with blood serum from CR and AL animals.

Allard, Joanne S.
Heilbronn, Leonie K.
Smith, Carolina
Hunt, Nicole D.
Ingram, Donald K.
Ravussin, Eric
Pennington CALERIE Team
de Cabo, Rafael
Publication Title: 
The Journal of Surgical Research

BACKGROUND: Lifespan extension is achieved through long-term application of dietary restriction (DR), and benefits of short-term dietary restriction on acute stress and inflammation have been observed. So far, the effects of short-term DR in humans are relatively unknown. We hypothesized that short-term DR in humans reduces the acute phase response following a well defined surgical trauma. METHODS: Thirty live kidney donors were randomized between 30% preoperative dietary restriction followed by 1 d of fasting (n=17) or a 4 d ad libitum regimen (n=13) prior to surgery.

van Ginhoven, Tessa M.
Dik, Willem A.
Mitchell, James R.
Smits-te Nijenhuis, Marja A.
van Holten-Neelen, Conny
Hooijkaas, Herbert
Hoeijmakers, Jan H. J.
de Bruin, Ron W. F.
IJzermans, Jan N. M.
Publication Title: 
Genes & Development

Adaptation to nutrient scarcity depends on the activation of metabolic programs to efficiently use internal reserves of energy. Activation of these programs in abundant food regimens can extend life span. However, the common molecular and metabolic changes that promote adaptation to nutritional stress and extend life span are mostly unknown. Here we present a response to fasting, enrichment of ?-6 polyunsaturated fatty acids (PUFAs), which promotes starvation resistance and extends Caenorhabditis elegans life span. Upon fasting, C.

O'Rourke, Eyleen J.
Kuballa, Petric
Xavier, Ramnik
Ruvkun, Gary
Publication Title: 
Current Opinion in Oncology

PURPOSE OF REVIEW: The purpose of this review is to highlight recent studies on mammalian sirtuins that coordinately regulate cellular metabolic homeostasis upon fasting and to summarize the beneficial effects of fasting on carcinogenesis and cancer therapy. RECENT FINDINGS: Recent studies have demonstrated that fasting may protect normal cells and mice from the metabolic conditions that are harmful as well as decrease the incidence of carcinogenesis. Fasting could also slow the tumor growth and augment the efficacy of certain systemic agents/chemotherapy drugs in various cancers.

Zhu, Yueming
Yan, Yufan
Gius, David R.
Vassilopoulos, Athanassios
Publication Title: 
Psychiatric Research Reports
Shock, N. W.
Publication Title: 
Ceskoslovensk· Gynekologie
Presl, J.
Publication Title: 
The British Journal of Nutrition

The longevity and excellent health status of the population of Crete has been attributed to its lifestyle and dietary habits. The impact of Greek Orthodox Christian Church fasting on these dietary habits has never been studied. One hundred and twenty Greek Orthodox Christians living in Crete participated in a 1-year prospective study. One half of the subjects, who fasted regularly (fasters), and sixty non-faster controls were followed longitudinally for the three main fasting periods over 1 year; Christmas (40 d), Lent (48 d) and the Assumption (15 d).

Sarri, Katerina O.
Linardakis, Manolis K.
Bervanaki, Frosso N.
Tzanakis, Nikolaos E.
Kafatos, Anthony G.
Publication Title: 
The American Journal of Clinical Nutrition

BACKGROUND: Prolonged dietary restriction increases the life span in rodents. Some evidence suggests that alternate-day fasting may also prolong the life span. OBJECTIVE: Our goal was to determine whether alternate-day fasting is a feasible method of dietary restriction in nonobese humans and whether it improves known biomarkers of longevity. DESIGN: Nonobese subjects (8 men and 8 women) fasted every other day for 22 d.

Heilbronn, Leonie K.
Smith, Steven R.
Martin, Corby K.
Anton, Stephen D.
Ravussin, Eric


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