Publication Title: 
EMBO reports

The nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) helps to translate 'what you eat' into 'what you are' because it allows dietary fatty acids (PPARgamma ligands) to modulate gene transcription. Treatments for diabetes include PPARgamma activators, as they sensitize the body to insulin. Our understanding of PPARgamma function has recently been enhanced by a flurry of human and mouse genetic studies, and the characterization of new PPARgamma ligands.

Cock, Terrie-Anne
Houten, Sander M.
Auwerx, Johan
Publication Title: 
Journal of Natural Medicines

In Ayurvedic medicine, Salacia reticulata is known to be useful against various metabolic diseases, including diabetes and obesity. In this study, we attempted to clarify the antiobesity mechanism and the safety of S. reticulata in vivo and in vitro. We gave ordinary MF feed, alone or mixed with S. reticulata (0.3 or 1.0%), to Tsumura Suzuki obesity diabetes (TSOD) mice (spontaneous obese type II diabetes model mice) and Tsumura Suzuki non-obese (TSNO) mice (the corresponding reference animals), ad libitum for 2 months.

Shimada, Tsutomu
Nagai, Eiichi
Harasawa, Yukiko
Akase, Tomoko
Aburada, Takashi
Iizuka, Seiichi
Miyamoto, Ken-ichi
Aburada, Masaki
Publication Title: 
Journal of Agricultural and Food Chemistry

The California Hass avocado ( Persea americana ) is an example of a domesticated berry fruit that matures on the tree during its growing season but ripens only after being harvested. Avocados are typically harvested multiple times during the growing season in California. Previous research has demonstrated potential health benefits of avocados and extracts of avocado against inflammation and cancer cell growth, but seasonal variations in the phytochemical profile of the fruits being studied may affect the results obtained in future research.

Lu, Qing-Yi
Zhang, Yanjun
Wang, Yue
Wang, David
Lee, Ru-po
Gao, Kun
Byrns, Russell
Heber, David
Publication Title: 
The Journal of Clinical Endocrinology and Metabolism

OBJECTIVE: In preclinical reports, restriction of dietary methionine intake was shown to enhance metabolic flexibility, improve lipid profiles, and reduce fat deposition. The present report is the outcome of a "proof of concept" study to evaluate the efficacy of dietary methionine restriction (MR) in humans with metabolic syndrome.

Plaisance, Eric P.
Greenway, Frank L.
Boudreau, Anik
Hill, Kasey L.
Johnson, William D.
Krajcik, Rozlyn A.
Perrone, Carmen E.
Orentreich, Norman
Cefalu, William T.
Gettys, Thomas W.
Publication Title: 
The American Journal of Physiology

To investigate whether brain leptin involves neuropeptidergic pathways influencing ingestion, metabolism, and gastrointestinal functioning, leptin (3.5 micrograms) was infused daily into the third cerebral ventricular of rats for 3 days. To distinguish between direct leptin effects and those secondary to leptin-induced anorexia, we studied vehicle-infused rats with food available ad libitum and those that were pair-fed to leptin-treated animals.

van Dijk, G.
Seeley, R. J.
Thiele, T. E.
Friedman, M. I.
Ji, H.
Wilkinson, C. W.
Burn, P.
Campfield, L. A.
Tenenbaum, R.
Baskin, D. G.
Woods, S. C.
Schwartz, M. W.
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