Fatty Acid-Binding Proteins

Publication Title: 
Toxicology and Applied Pharmacology

Excess cardiac triglyceride accumulation in diabetes and obesity induces lipotoxicity, which predisposes the myocytes to death. On the other hand, increased cardiac fatty acid (FA) oxidation plays a role in the development of myocardial dysfunction in diabetes. PPAR-alpha plays an important role in maintaining homeostasis of lipid metabolism.

Author(s): 
Huang, Tom Hsun-Wei
Yang, Qinglin
Harada, Masaki
Uberai, Jasna
Radford, Jane
Li, George Q.
Yamahara, Johji
Roufogalis, Basil D.
Li, Yuhao
Publication Title: 
Metabolism: Clinical and Experimental

Fatty acid binding protein (FABP) 4 chaperones free fatty acids (FFAs) in the adipocytes during lipolysis. Serum FFA relates to metabolic syndrome, and serum FABP4 is emerging as a novel risk marker. In 36 overweight/obese women, serum FABP4 and FFA were measured hourly during 5-hour oral glucose tolerance test. Insulin resistance was determined using frequently sampled intravenous glucose tolerance test. Serum lipids and inflammation markers were measured at fasting.

Author(s): 
Karakas, Sidika E.
Almario, Rogelio U.
Kim, Kyoungmi
Publication Title: 
PloS One

BACKGROUND: There is an inverse secular trend between the incidence of obesity and gastric colonization with Helicobacter pylori, a bacterium that can affect the secretion of gastric hormones that relate to energy homeostasis. H. pylori strains that carry the cag pathogenicity island (PAI) interact more intimately with gastric epithelial cells and trigger more extensive host responses than cag(-) strains. We hypothesized that gastric colonization with H. pylori strains differing in cag PAI status exert distinct effects on metabolic and inflammatory phenotypes.

Author(s): 
Bassaganya-Riera, Josep
Dominguez-Bello, Maria Gloria
Kronsteiner, Barbara
Carbo, Adria
Lu, Pinyi
Viladomiu, Monica
Pedragosa, Mireia
Zhang, Xiaoying
Sobral, Bruno W.
Mane, Shrinivasrao P.
Mohapatra, Saroj K.
Horne, William T.
Guri, Amir J.
Groeschl, Michael
Lopez-Velasco, Gabriela
Hontecillas, Raquel
Publication Title: 
Scientific Reports

FAAH-like anandamide transporter (FLAT) regulates anandamide transport for hydrolysis and may be an attractive drug target for pain regulation. We aimed to discover potential FLAT antagonists from traditional Chinese medicine (TCM) using virtual screening, ligand-based drug design and molecular dynamics simulation (MD). Guineensine and Retrofractamide A exhibited high Dock Scores in FLAT.

Author(s): 
Tou, Weng Ieong
Chang, Su-Sen
Lee, Cheng-Chun
Chen, Calvin Yu-Chian
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