Fatty Acids, Omega-6

Publication Title: 
Genes & Development

Adaptation to nutrient scarcity depends on the activation of metabolic programs to efficiently use internal reserves of energy. Activation of these programs in abundant food regimens can extend life span. However, the common molecular and metabolic changes that promote adaptation to nutritional stress and extend life span are mostly unknown. Here we present a response to fasting, enrichment of ?-6 polyunsaturated fatty acids (PUFAs), which promotes starvation resistance and extends Caenorhabditis elegans life span. Upon fasting, C.

Author(s): 
O'Rourke, Eyleen J.
Kuballa, Petric
Xavier, Ramnik
Ruvkun, Gary
Publication Title: 
BMJ (Clinical research ed.)
Author(s): 
Vos, Eddie
Publication Title: 
Minerva Pediatrica

In 1929 Burr and Burr discovered the essential fatty acids omega-6 and omega-3. Since then, researchers have shown a growing interest in unsaturated essential fatty acids as they form the framework for the organism's cell membranes, particularly the neurones in the brain, are involved in the energy-transformation process, regulate the information flows between cells.

Author(s): 
Caramia, G.
Publication Title: 
Genes & Development

Adaptation to nutrient scarcity depends on the activation of metabolic programs to efficiently use internal reserves of energy. Activation of these programs in abundant food regimens can extend life span. However, the common molecular and metabolic changes that promote adaptation to nutritional stress and extend life span are mostly unknown. Here we present a response to fasting, enrichment of ?-6 polyunsaturated fatty acids (PUFAs), which promotes starvation resistance and extends Caenorhabditis elegans life span. Upon fasting, C.

Author(s): 
O'Rourke, Eyleen J.
Kuballa, Petric
Xavier, Ramnik
Ruvkun, Gary
Publication Title: 
Cellular and Molecular Biology (Noisy-Le-Grand, France)

Holistica Laboratories (Eguilles, France) developed the nutritional supplements Omegacoeur® and Doluperine® based on two of the most ancient and unique dietary health traditions. Omegacoeur® is formulated to supply key active components of Mediterranean diet (omega 3,6,9 fatty acids, garlic, and basil) and the formulation of Doluperine® was based on the Ayurvedic tradition (curcuma, pepper, ginger extracts).

Author(s): 
Sottejeau, Y.
Patel, A. M.
Gerber, G.
Pierre, S. V.
Maixent, J. M.
Publication Title: 
Clinical Cancer Research: An Official Journal of the American Association for Cancer Research

PURPOSE: To determine whether altering the dietary content of omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids affects the growth of androgen-sensitive prostate cancer xenografts, tumor membrane fatty acid composition, and tumor cyclooxygenase-2 and prostaglandin E(2) (PGE(2)) levels. EXPERIMENTAL DESIGN: Individually caged male severe combined immunodeficiency mice were fed isocaloric 20% kcal fat diets with the fat derived either primarily from n-6 fatty acids (n-6 group) or with the fat consisting of n-6 and n-3 fatty acids in a ratio of 1:1 (n-3 group), and injected s.c.

Author(s): 
Kobayashi, Naoko
Barnard, R. James
Henning, Susanne M.
Elashoff, David
Reddy, Srinivasa T.
Cohen, Pinchas
Leung, Pak
Hong-Gonzalez, Jenny
Freedland, Stephen J.
Said, Jonathan
Gui, Dorina
Seeram, Navindra P.
Popoviciu, Laura M.
Bagga, Dilprit
Heber, David
Glaspy, John A.
Aronson, William J.
Publication Title: 
The American Journal of Clinical Nutrition

Changes in diet over the past century have markedly altered the consumption of fatty acids. The dramatic increase in the ingestion of saturated and n-6 fatty acids and concomitant decrease in n-3 fatty acids are thought to be a major driver of the increase in the incidence of inflammatory diseases such as asthma, allergy, and atherosclerosis.

Author(s): 
Chilton, Floyd H.
Rudel, Lawrence L.
Parks, John S.
Arm, Jonathan P.
Seeds, Michael C.
Publication Title: 
Journal of Lipid Research

Long-chain polyunsaturated fatty acids (PUFA) orchestrate immunity and inflammation through their capacity to be converted to potent inflammatory mediators. We assessed associations of FADS gene cluster polymorphisms and fasting serum PUFA concentrations in a fully ascertained, geographically isolated founder population of European descent. Concentrations of 22 PUFAs were determined by gas chromatography, of which ten fatty acids and five ratios defining FADS1 and FADS2 activity were tested for genetic association against 16 single nucleotide polymorphisms (SNP) in 224 individuals.

Author(s): 
Mathias, Rasika A.
Vergara, Candelaria
Gao, Li
Rafaels, Nicholas
Hand, Tracey
Campbell, Monica
Bickel, Carol
Ivester, Priscilla
Sergeant, Susan
Barnes, Kathleen C.
Chilton, Floyd H.
Publication Title: 
Pharmacological Research: The Official Journal of the Italian Pharmacological Society

Fish oil has been used to alleviate pain associated with inflammatory conditions such as rheumatoid arthritis. The anti-inflammatory property of fish oil is attributed to the n-3 fatty acids docosahexaenoic acid and eicosapentaenoic acid. Contrarily, vegetable oils such as safflower oil are rich in n-6 fatty acids which are considered to be mediators of inflammation. This study investigates the effect of n-3 and n-6 fatty acids rich oils as dietary supplements on the thermally induced pain sensitivity in healthy mice.

Author(s): 
Veigas, Jyothi M.
Williams, Paul J.
Halade, Ganesh
Rahman, Mizanur M.
Yoneda, Toshiyuki
Fernandes, Gabriel
Publication Title: 
Trials

BACKGROUND: Targeted analgesic dietary interventions are a promising strategy for alleviating pain and improving quality of life in patients with persistent pain syndromes, such as chronic daily headache (CDH). High intakes of the omega-6 (n-6) polyunsaturated fatty acids (PUFAs), linoleic acid (LA) and arachidonic acid (AA) may promote physical pain by increasing the abundance, and subsequent metabolism, of LA and AA in immune and nervous system tissues.

Author(s): 
Ramsden, Christopher E.
Mann, J. Douglas
Faurot, Keturah R.
Lynch, Chanee
Imam, Syed Taha
Macintosh, Beth A.
Hibbeln, Joseph R.
Loewke, James
Smith, Sunyata
Coble, Rebecca
Suchindran, Chirayath
Gaylord, Susan A.

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