Ferric Compounds

Publication Title: 
Biological & Pharmaceutical Bulletin

The ripe fruit of Terminalia chebula RETZIUS (T. chebula RETZ) (Combretsceae), which is a native plant in India and Southeast Asia, has traditionally been used as a popular folk medicine for homeostatic, antitussive, laxative, diuretic, and cardiotonic treatments. The objective of this study was to evaluate the protective effects of an aqueous extract of fruit of T. chebula on the tert-butyl hydroperoxide (t-BHP)-induced oxidative injury observed in cultured rat primary hepatocytes and rat liver. Both treatment and pretreatment of the hepatocytes with the T.

Author(s): 
Lee, Hyun-Sun
Won, Nam Hee
Kim, Kyoung Heon
Lee, Hojoung
Jun, Woojin
Lee, Kwang-Won
Publication Title: 
Die Pharmazie

In an effort to identify a new chemopreventive agent, the present study was conducted to investigate the role of T. chebula in the prevention of ferric nitrilotriacetic acid (Fe- NTA) induced oxidative stress and renal tumorigenesis in Wistar rats. A single application of Fe-NTA (9 mg Fe/kg body weight, intraperitoneally) significantly induced oxidative stress and elevated the marker parameters of tumor promotion. However, the pretreatment of animals with different doses of T.

Author(s): 
Prasad, L.
Khan, T. H.
Jahangir, T.
Sultana, S.
Publication Title: 
PloS One

Stem cells are increasingly the focus of translational research as well as having emerging roles in human cellular therapy. To support these uses there is a need for improved methods for in vivo cell localization and tracking. In this study, we examined the effects of cell labeling on the in vitro functionality of human adipose-derived mesenchymal stem cells. Our results provide a basis for future in vivo studies investigating implanted cell fate and longevity.

Author(s): 
Blaber, Sinead P.
Hill, Cameron J.
Webster, Rebecca A.
Say, Jana M.
Brown, Louise J.
Wang, Shih-Chang
Vesey, Graham
Herbert, Benjamin Ross
Publication Title: 
Journal of Toxicology and Environmental Health. Part A

The use of dietary adsorbents to reduce arsenic (As) exposure is innovative. Ferrihydrite successfully sorbs arsenite and asenate over a wide range of pH conditions and the As-ferrihydrite complexes are stable in gastrointestinal (GIT) models.

Author(s): 
Taylor, John F.
Robinson, Abraham
Mitchell, Nicole J.
Marroquin-Cardona, Alicia
Johnson, Natalie
Elmore, Sarah E.
Romoser, Amelia A.
Phillips, Timothy D.
Publication Title: 
Advances in Food and Nutrition Research

There are a multitude of antioxidants in foods, especially in foods of plant origin. Higher intake of antioxidant-rich foods is clearly associated with better health and functional longevity. The specific agents and mechanisms responsible are not yet clear, but there is convincing evidence that including more plant-based, antioxidant-rich foods, herbs, and beverages in the diet is effective in promoting health and lowering risk of various age-related diseases.

Author(s): 
Benzie, Iris F. F.
Choi, Siu-Wai
Publication Title: 
Chemical & Pharmaceutical Bulletin

Artemisinin, a sesquiterpene with endoperoxide bond, possesses potent antimalarial activity against the ring and late stage of chloroqine-resistant Plasmodium falciparum malaria both in vitro and in vivo. The mode of antimalarial activity of artemisinin is iron-dependent. The aim of this study was to investigate the reactions of artemisinin with ferrous and ferric ions in aqueous buffer. Artemisinin generated a cycle of iron oxidation and reduction.

Author(s): 
Sibmooh, N.
Udomsangpetch, R.
Kujoa, A.
Chantharaksri, U.
Mankhetkorn, S.
Publication Title: 
Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences

BACKGROUND: Artemisinin is the major sesquiterpene lactones in sweet wormwood (Artemisia annua L.), and its combination with transferrin exhibits versatile anti-cancer activities. Their non-selective targeting for cancer cells, however, limits their application. The aim of this study was to prepare the artemisinin and transferrin-loaded magnetic nanoliposomes in thermosensitive and non-thermosensitive forms and evaluate their antiproliferative activity against MCF-7 and MDA-MB-231 cells for better tumor-targeted therapy.

Author(s): 
Gharib, Amir
Faezizadeh, Zohreh
Mesbah-Namin, Seyed Ali Reza
Saravani, Ramin
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Cellular damage induced by free-radicals like Reactive Oxygen and Nitrogen Species (ROS and RNS) has been implicated in several disorders and diseases, including ageing. Hence naturally occurring anti-oxidant rich-herbs play a vital role in combating these conditions. The present study was carried out to investigate the in vitro free-radical quenching capacity of a known Ayurvedic poly-herbal formulation called Vayasthapana Rasayana.

Author(s): 
Mukherjee, Sourav
Pawar, Nayana
Kulkarni, Omkar
Nagarkar, Bhagyashri
Thopte, Shrikant
Bhujbal, Akshay
Pawar, Pankaj
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Traditional Indian and Australian medicinal plant extracts were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of hyperglycemia and type 2 diabetes. The antioxidant activities were also assessed. METHODS: The evaluation of enzyme inhibitory activity of seven Australian aboriginal medicinal plants and five Indian Ayurvedic plants was carried out against α-amylase and α-glucosidase.

Author(s): 
Gulati, Vandana
Harding, Ian H.
Palombo, Enzo A.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Cellular damage induced by free-radicals like Reactive Oxygen and Nitrogen Species (ROS and RNS) has been implicated in several disorders and diseases, including ageing. Hence naturally occurring anti-oxidant rich-herbs play a vital role in combating these conditions. The present study was carried out to investigate the in vitro free-radical quenching capacity of a known Ayurvedic poly-herbal formulation called Vayasthapana Rasayana.

Author(s): 
Mukherjee, Sourav
Pawar, Nayana
Kulkarni, Omkar
Nagarkar, Bhagyashri
Thopte, Shrikant
Bhujbal, Akshay
Pawar, Pankaj

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