Fetal Blood

Publication Title: 
Aging Cell

Aging poses one of the largest risk factors for the development of cardiovascular disease. The increased propensity toward vascular pathology with advancing age maybe explained, in part, by a reduction in the ability of circulating endothelial progenitor cells to contribute to vascular repair and regeneration. Although there is evidence to suggest that colony forming unit-Hill cells and circulating angiogenic cells are subject to age-associated changes that impair their function, the impact of aging on human outgrowth endothelial cell (OEC) function has been less studied.

Author(s): 
Williamson, Kate A.
Hamilton, Andrew
Reynolds, John A.
Sipos, Peter
Crocker, Ian
Stringer, Sally E.
Alexander, Yvonne M.
Publication Title: 
Nature Communications

Insulin-like growth factor 1 (IGF-1) is a critical regulator of many physiological functions, ranging from longevity to immunity. However, little is known about the role of IGF-1 in natural killer cell development and function. Here, we identify an essential role for IGF-1 in the positive regulation of human natural killer cell development and cytotoxicity. Specifically, we show that human natural killer cells have the ability to produce IGF-1 and that differential endogenous IGF-1 expression leads to disparate cytotoxicity in human primary natural killer cells.

Author(s): 
Ni, Fang
Sun, Rui
Fu, Binqing
Wang, Fuyan
Guo, Chuang
Tian, Zhigang
Wei, Haiming
Publication Title: 
American Journal of Obstetrics and Gynecology

OBJECTIVE: In adults, one of the major determinants of leukocyte telomere length (LTL), a predictor of age-related diseases and mortality, is cumulative psychosocial stress exposure. More recently we reported that exposure to maternal psychosocial stress during intrauterine life is associated with LTL in young adulthood. The objective of the present study was to determine how early in life this effect of stress on LTL is apparent by quantifying the association of maternal psychosocial stress during pregnancy with newborn telomere length.

Author(s): 
Entringer, Sonja
Epel, Elissa S.
Lin, Jue
Buss, Claudia
Shahbaba, Babak
Blackburn, Elizabeth H.
Simhan, Hyagriv N.
Wadhwa, Pathik D.
Publication Title: 
American Journal of Obstetrics and Gynecology

OBJECTIVE: In adults, one of the major determinants of leukocyte telomere length (LTL), a predictor of age-related diseases and mortality, is cumulative psychosocial stress exposure. More recently we reported that exposure to maternal psychosocial stress during intrauterine life is associated with LTL in young adulthood. The objective of the present study was to determine how early in life this effect of stress on LTL is apparent by quantifying the association of maternal psychosocial stress during pregnancy with newborn telomere length.

Author(s): 
Entringer, Sonja
Epel, Elissa S.
Lin, Jue
Buss, Claudia
Shahbaba, Babak
Blackburn, Elizabeth H.
Simhan, Hyagriv N.
Wadhwa, Pathik D.
Publication Title: 
Epigenetics

Prenatal exposure both to maternal psychiatric illness and psychiatric medication has been linked with adverse child outcomes that affect physiological, emotional and psychiatric development. Studies suggest that epigenetic mechanisms, such as DNA methylation, may facilitate these effects. In this report, we explore the association between maternal psychiatric illness and treatment during pregnancy and neonatal DNA methylation patterns in a prospectively-characterized clinical cohort of 201 dyads.

Author(s): 
Schroeder, James W.
Smith, Alicia K.
Brennan, Patricia A.
Conneely, Karen N.
Kilaru, Varun
Knight, Bettina T.
Newport, D. Jeffrey
Cubells, Joseph F.
Stowe, Zachary N.
Publication Title: 
Journal of Psychiatric Research

BACKGROUND: The methylation status of the human glucocorticoid receptor gene NR3C1 in newborns has been reported to be sensitive to prenatal maternal mood. This study investigates both the association between maternal cortisol and emotional state during pregnancy and the methylation state of the promoter region of NR3C1 gene. METHODS: We examined 83 pregnant women. Psychological data and diurnal cortisol data were assessed to evaluate maternal stress once each trimester.

Author(s): 
Hompes, Titia
Izzi, Benedetta
Gellens, Edith
Morreels, Maarten
Fieuws, Steffen
Pexsters, Anne
Schops, Ganel
Dom, Myriam
Van Bree, Rieta
Freson, Kathleen
Verhaeghe, Johan
Spitz, Bernard
Demyttenaere, Koen
Glover, Vivette
Van den Bergh, Bea
Allegaert, Karel
Claes, Stephan
Publication Title: 
Translational Psychiatry

Early life stress (ELS) is associated with increased vulnerability for diseases in later life, including psychiatric disorders. Animal models and human studies suggest that this effect is mediated by epigenetic mechanisms. In humans, epigenetic studies to investigate the influence of ELS on psychiatric phenotypes are limited by the inaccessibility of living brain tissue.

Author(s): 
Nieratschker, V.
Massart, R.
Gilles, M.
Luoni, A.
Suderman, M. J.
Krumm, B.
Meier, S.
Witt, S. H.
Nˆthen, M. M.
Suomi, S. J.
Peus, V.
Scharnholz, B.
Dukal, H.
Hohmeyer, C.
Wolf, I. a.-C.
Cirulli, F.
Gass, P.
S¸tterlin, M. W.
Filsinger, B.
Laucht, M.
Riva, M. A.
Rietschel, M.
Deuschle, M.
Szyf, M.
Publication Title: 
Translational Psychiatry

Depression affects 10-15% of pregnant women and has been associated with preterm delivery and later developmental, behavioural and learning disabilities. We tested the hypothesis that maternal depression is associated with DNA methylation alterations in maternal T lymphocytes, neonatal cord blood T lymphocytes and adult offspring hippocampi. Genome-wide DNA methylation of CD3+ T lymphocytes isolated from 38 antepartum maternal and 44 neonatal cord blood samples were analyzed using Illumina Methylation 450?K microarrays.

Author(s): 
Nemoda, Z.
Massart, R.
Suderman, M.
Hallett, M.
Li, T.
Coote, M.
Cody, N.
Sun, Z. S.
Soares, C. N.
Turecki, G.
Steiner, M.
Szyf, M.
Publication Title: 
Journal of Women's Health

Promising clinical results suggest that umbilical cord blood (UCB) collected after delivery of a child may have many advantages over bone marrow for transplantation. As there are an increasing number of options regarding the collection of UCB, including private and public banking, more pregnant women are likely to be asked to make decisions about UCB collection. We conducted three focus groups with pregnant women to learn about their perspectives on this emerging technology. All the women in these focus groups indicated that they would choose to have UCB collected.

Author(s): 
Sugarman, J.
Kaplan, L.
Cogswell, B.
Olson, J.
Publication Title: 
CMAJ: Canadian Medical Association journal = journal de l'Association medicale canadienne

BACKGROUND: Umbilical cord blood is used as a source of hematopoietic stem cells for bone marrow transplantation in the treatment of malignant and nonmalignant disease. We sought to examine pregnant women's knowledge and attitudes regarding cord blood banking, as their support is crucial to the success of cord blood transplant programs. METHODS: A questionnaire examining sociodemographic factors and women's attitudes to cord blood banking was developed on the basis of findings from 2 focus groups and a pilot study.

Author(s): 
Fernandez, Conrad V.
Gordon, Kevin
Van den Hof, Michiel
Taweel, Shaureen
Baylis, FranÁoise

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