Fetal Diseases

Publication Title: 
American Journal of Medical Genetics

We report on 2 unusual cases of the campomelic syndrome, the first being a fetus in whom the diagnosis was suspected in the 18th week and confirmed sonographically at 20 weeks. The second case concerns a 5 year old 46, XY girl with an exceptional longevity and a relatively favorable evolution.

Gillerot, Y.
Vanheck, C. A.
Foulon, M.
Podevain, A.
Koulischer, L.
Publication Title: 
Nature Clinical Practice. Endocrinology & Metabolism

Epidemiological evidence suggests that an adverse prenatal environment permanently 'programs' physiology and increases the risk of cardiovascular, metabolic, neuroendocrine and psychiatric disorders in adulthood. Prenatal stress or exposure to excess glucocorticoids might provide the link between fetal maturation and adult pathophysiology.

Seckl, Jonathan R.
Holmes, Megan C.
Publication Title: 
BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology

Gestational factors play a role in the development of several neuropsychiatric disorders including schizophrenia and autism. In utero conditions influence future mental health through epigenetic mechanisms, which alter gene expression without affecting DNA coding sequence. Environmental factors account for at least 60% of the risk for developing major depression, and earlier onset of depressive illness has been observed over the past decades. I speculate that gestational factors may play a greater role in programing depression than previously recognized.

Dulawa, Stephanie C.
Publication Title: 
Fetal Diagnosis and Therapy

This paper examines whether and to what extent parents are morally bound to seek reproductive genetic testing. It is concluded that, with rare exceptions, there is no requirement in parenting to seek or accept reproductive genetic testing if the only actions facilitated by such testing are abortion, selective conception or remaining childless. Commitments to other family members or to oneself can provide other, morally or prudentially compelling reasons to elect genetic testing and selective abortion in these circumstances.

Faden, Ruth
Publication Title: 
Health Technology Assessment (Winchester, England)

BACKGROUND: Congenital lower urinary tract obstruction (LUTO) is a disease associated with high perinatal mortality and childhood morbidity. Fetal vesicoamniotic shunting (VAS) bypasses the obstruction with the potential to improve outcome. OBJECTIVE: To determine the effectiveness, cost-effectiveness and patient acceptability of VAS for fetal LUTO. DESIGN: A multicentre, randomised controlled trial incorporating a prospective registry, decision-analytic health economic model and preplanned Bayesian analysis using elicited opinions.

Morris, R. K.
Malin, G. L.
Quinlan-Jones, E.
Middleton, L. J.
Diwakar, L.
Hemming, K.
Burke, D.
Daniels, J.
Denny, E.
Barton, P.
Roberts, T. E.
Khan, K. S.
Deeks, J. J.
Kilby, M. D.
Publication Title: 
Malaria Journal

BACKGROUND: Malaria during pregnancy results in adverse outcomes for mothers and infants. Intermittent preventive treatment (IPT) with sulphadoxine-pyrimethamine (SP) is the primary intervention aimed at reducing malaria infection during pregnancy. Although submicroscopic infection is common during pregnancy and at delivery, its impact throughout pregnancy on the development of placental malaria and adverse pregnancy outcomes has not been clearly established.

Cohee, Lauren M.
Kalilani-Phiri, Linda
Boudova, Sarah
Joshi, Sudhaunshu
Mukadam, Rabia
Seydel, Karl B.
Mawindo, Patricia
Thesing, Phillip
Kamiza, Steve
Makwakwa, Kingsley
Muehlenbachs, Atis
Taylor, Terrie E.
Laufer, Miriam K.
Publication Title: 
Molecular Nutrition & Food Research

SCOPE: Diabetic embryopathy, a consequence of diabetic pregnancy, is associated with increase in embryonic oxidative stress and apoptosis, which lead to severe embryonic damage at early stage of organogenesis. METHODS AND RESULTS: This study investigated if resveratrol, found in red grapes and blue-berries, may prevent diabetes-induced oxidative stress and apoptosis in embryos and have beneficial effects in diabetic dams. A rodent model of diabetic embryopathy was used.

Singh, Chandra K.
Kumar, Ambrish
Hitchcock, David B.
Fan, Daping
Goodwin, Richard
LaVoie, Holly A.
Nagarkatti, Prakash
Dipette, Donald J.
Singh, Ugra S.
Publication Title: 
Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan / Sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine

Chinese Goldthread Rhizome is prohibited in Singapore since it is thought to induce neonatal jaundice. In literatures of traditional Chinese medicine, this drug was never treated as a contraindicant for pregnancy, and there were no records and reports on it inducing neonatal jaundice. The results of the authors's experiments showed that Chinese Goldthread Rhizome and berberine had no induction of neonatal jaundice in pregnant rats and mice and newly born rats, and had no influence either on the activity of glucose-6-phosphate dehydrogenase of mice red blood cells.

Yang, Shouye
Wang, Xuhua
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