Fetal Nutrition Disorders

Publication Title: 
Brain Research

Diet restriction of rodents during adult life is known to cause an increased life span. It has been hypothesised that this increase may be related to effects on the anti-oxidant defence systems. However, it has been suggested that undernutrition during the gestation and pre-weaning may reduce their life span as it is known to have other deleterious effects on a rodent's growth and development.

Partadiredja, G.
Worrall, S.
Bedi, K. S.
Publication Title: 
Schizophrenia Bulletin

Converging evidence suggests that a neurodevelopmental disruption plays a role in the vulnerability to schizophrenia. The authors review evidence supporting in utero exposure to nutritional deficiency as a determinant of schizophrenia. We first describe studies demonstrating that early gestational exposure to the Dutch Hunger Winter of 1944--1945 and to a severe famine in China are each associated with an increased risk of schizophrenia in offspring.

Brown, Alan S.
Susser, Ezra S.
Publication Title: 
Molecular Medicine Reports

Perturbations in the levels of serotonin expression have a significant impact on behavior and have been implicated in the pathogenesis of several neuropsychiatric disorders including anxiety, mood and appetite. Fetal programming is a risk factor for the development of metabolic diseases during adulthood. Moreover, previous studies have shown that serotonin (5‑HT), dopamine and leptin are important in energy balance.

Manuel-Apolinar, Leticia
Rocha, Luisa
Damasio, Leticia
Tesoro-Cruz, Emiliano
Zarate, Arturo
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