Fibrinogen

Publication Title: 
The American Journal of Tropical Medicine and Hygiene

Dengue virus (DENV) is considered to be the most important arthropod-borne viral disease and causes more than 100 million human infections annually. To further characterize primary DENV infection in vivo, rhesus macaques were infected with DENV-1, DENV-2, DENV-3, or DENV-4 and clinical parameters, as well as specificity and longevity of serologic responses, were assessed. Overt clinical symptoms were not present after infection.

Author(s): 
Hickey, Andrew C.
Koster, Jacob A.
Thalmann, Claudia M.
Hardcastle, Kathy
Tio, Phaik-Hooi
Cardosa, Mary J.
Bossart, Katharine N.
Publication Title: 
Molecular Nutrition & Food Research

Interest in the Mediterranean diet (MD) has grown worldwide due to its link with greater longevity and lower cardiovascular disease rate, cancer and age cognitive decline. Despite the high complexity of its nutrients composition, olive oil emerges as its principal food, since it provides the higher percent of energy and a lot of bioactive compounds. In this review we will discuss the benefits of diets enriched in virgin olive oil, whose effects are probably due not only to its oleic acid content but also to its other potentially health-promoting components.

Author(s): 
Lopez-Miranda, Jose
Delgado-Lista, Javier
Perez-Martinez, Pablo
Jimenez-GÛmez, Yolanda
Fuentes, Francisco
Ruano, Juan
Marin, Carmen
Publication Title: 
Thrombosis Et Diathesis Haemorrhagica

Various parameters of the coagulation system have been monitored in patients with Christmas disease following the infusion of clotting factor concentrates. Significant reduction of clotting factor VIII and serum antithrombin III were observed in each of the five studies, whilst the plasma fibrinogen level fell in four subjects. The induced abnormalities were shortlived and there were no clinical sequelae. Further studies are required to assess the effects of similar concentrates in patients with liver disease.

Author(s): 
Preston, F. E.
Winfield, D. A.
Malia, R. G.
Blackburn, E. K.
Publication Title: 
British Medical Journal
Author(s): 
Preston, F. E.
Malia, R. G.
Blackburn, E. K.
Platts, M.
Publication Title: 
Journal of Psychiatric Research

Systemic inflammation is proposed as a putative mechanism underlying the link between poor sleep and cardiovascular disease. The aim of present study was to investigate the cross-sectional and prospective associations of self-reported sleep quality with biomarkers of inflammation and coagulation implicated in coronary heart disease (CHD) and to explore whether these associations differed between men and women.

Author(s): 
Prather, Aric A.
Epel, Elissa S.
Cohen, Beth E.
Neylan, Thomas C.
Whooley, Mary A.
Publication Title: 
Journal of Neurology, Neurosurgery, and Psychiatry

Three cases with intracranial lesions developed evidence of disseminated intravascular coagulation which was confirmed at necropsy. The factors engendering this state, including release of potent thromboplastin from neural tissue are discussed and the danger of this intermediary mechanism of disease increasing the mortality of intracranial disease is demonstrated. Careful haematological investigation of all patients with intracranial disease is therefore advised, especially if they manifest evidence of a bleeding tendency.

Author(s): 
Preston, F. E.
Malia, R. G.
Sworn, M. J.
Timperley, W. R.
Blackburn, E. K.
Publication Title: 
Psychiatria Danubina

BACKGROUND: Previous research has shown that metabolic syndrome as well as early life stress can account for immunoactivation (e.g. in the form of altered fibrinogen levels) in patients with major depression. This study aims at assessing the relationship between components of metabolic syndrome, early life stress and fibrinogen levels, taking the severity of depression into consideration. SUBJECTS AND METHODS: Measures of early life stress and signs of metabolic syndrome were collected in 58 adult inpatients diagnosed with depression.

Author(s): 
Zeugmann, Sara
Quante, Arnim
Popova-Zeugmann, Louchka
Kˆssler, Wolfgang
Heuser, Isabella
Anghelescu, Ion
Publication Title: 
Cellular and molecular life sciences: CMLS

Snake envenomation is a socio-medical problem of considerable magnitude. About 2.5 million people are bitten by snakes annually, more than 100,000 fatally. However, although bites can be deadly, snake venom is a natural biological resource that contains several components of potential therapeutic value. Venom has been used in the treatment of a variety of pathophysiological conditions in Ayurveda, homeopathy and folk medicine.

Author(s): 
Koh, D. C. I.
Armugam, A.
Jeyaseelan, K.
Publication Title: 
Menopause (New York, N.Y.)

OBJECTIVE: C-reactive protein and fibrinogen are established atherosclerotic cardiovascular disease risk factors. These acute-phase proteins and the proinflammatory cytokines tumor necrosis factor alpha, interleukin-6, and interleukin-1beta may be elevated in obesity and with menopause. The purpose of this multicenter study was to identify whether centrally located fat and/or overall adiposity were related to these inflammatory markers in healthy postmenopausal women.

Author(s): 
Perry, Courtney D.
Alekel, D. Lee
Ritland, Laura M.
Bhupathiraju, Shilpa N.
Stewart, Jeanne W.
Hanson, Laura N.
Matvienko, Oksana A.
Kohut, Marian L.
Reddy, Manju B.
Van Loan, Marta D.
Genschel, Ulrike
Publication Title: 
Cellular and molecular life sciences: CMLS

Snake envenomation is a socio-medical problem of considerable magnitude. About 2.5 million people are bitten by snakes annually, more than 100,000 fatally. However, although bites can be deadly, snake venom is a natural biological resource that contains several components of potential therapeutic value. Venom has been used in the treatment of a variety of pathophysiological conditions in Ayurveda, homeopathy and folk medicine.

Author(s): 
Koh, D. C. I.
Armugam, A.
Jeyaseelan, K.

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