Flavones

Publication Title: 
PloS One

The number of fully active antibiotic options that treat nosocomial infections due to multidrug-resistant Acinetobacter baumannii (A. baumannii) is extremely limited. Magnolia officinalis, Mahonia bealei, Rabdosia rubescens, Rosa rugosa, Rubus chingii, Scutellaria baicalensis, and Terminalia chebula plant extracts were previously shown to have growth inhibitory activity against a multidrug-resistant clinical strain of A. baumannii.

Author(s): 
Miyasaki, Yoko
Rabenstein, John D.
Rhea, Joshua
Crouch, Marie-Laure
Mocek, Ulla M.
Kittell, Patricia Emmett
Morgan, Margie A.
Nichols, Wesley Stephen
Van Benschoten, M. M.
Hardy, William David
Liu, George Y.
Publication Title: 
Frontiers in Bioscience: A Journal and Virtual Library

The use of complementary and alternative medicine (CAM) is increasing rapidly in developed countries, which is already in use as traditional medicines in various Asian countries. The Indian system of medicine, named as Ayurveda has an edge in this field. Many plant products are in use as herbal medicine, as food supplement or as spices, in every day cooking. Some of them have been well studied in various experimental models of cancer, both in vivo and in vitro models. They have shown significant inhibition of cell proliferation.

Author(s): 
Tripathi, Yamini B.
Tripathi, Pratibha
Arjmandi, Behram H.
Publication Title: 
Frontiers in Bioscience: A Journal and Virtual Library

The use of complementary and alternative medicine (CAM) is increasing rapidly in developed countries, which is already in use as traditional medicines in various Asian countries. The Indian system of medicine, named as Ayurveda has an edge in this field. Many plant products are in use as herbal medicine, as food supplement or as spices, in every day cooking. Some of them have been well studied in various experimental models of cancer, both in vivo and in vitro models. They have shown significant inhibition of cell proliferation.

Author(s): 
Tripathi, Yamini B.
Tripathi, Pratibha
Arjmandi, Behram H.
Publication Title: 
Journal of Natural Medicines

Njavara is an important medicinal rice variety of Kerala, India widely used in Ayurveda for the treatment of rheumatoid arthritis, paralysis, neurodegenerative diseases and in rejuvenation therapy. The study evaluated, for the first time, antitumor effects of the two rare flavonolignans, tricin 4'-O-(erythro-β-guaiacylglyceryl) ether (compound 1) and tricin 4'-O-(threo-β-guaiacylglyceryl) ether (compound 2), isolated from 'Njavara' black.

Author(s): 
Mohanlal, Smitha
Maney, Sathish Kumar
Santhoshkumar, Thankayyan Retnabai
Jayalekshmy, Ananthasankaran
Publication Title: 
Drug Metabolism and Disposition: The Biological Fate of Chemicals

The female flowers of hops are used throughout the world as a flavoring agent for beer. Recently, there has been increasing interest in the potential estrogenic properties of hop extracts. Among the possible estrogenic compounds in hops, 8-prenylnaringenin is perhaps most significant due to its high in vitro potency exceeding that of other known phytoestrogens. Since data regarding the pharmacokinetic properties of this compound are lacking, we investigated the in vitro metabolism of 8-prenylnaringenin by human liver microsomes.

Author(s): 
Nikolic, Dejan
Li, Yongmei
Chadwick, Lucas R.
Grubjesic, Simonida
Schwab, Pia
Metz, Peter
van Breemen, Richard B.
Publication Title: 
The Journal of Biological Chemistry

Flavonoids have been suggested to exert human health benefits by anti-oxidant and anti-inflammatory mechanisms. In this study, we investigated whether and by what mechanisms dietary flavonoids inhibit expression of cellular adhesion molecules, which is relevant to inflammation and atherosclerosis. We found that the capacity of flavonoids to inhibit tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells was dependent on specific structural features of the flavonoids.

Author(s): 
Lotito, Silvina B.
Frei, Balz
Publication Title: 
Annals of Clinical Microbiology and Antimicrobials

BACKGROUND: Due to the indiscriminate use of antimicrobial drugs, the emergence of human pathogenic microorganisms resistant to major classes of antibiotics has been increased and has caused many clinical problems in the treatment of infectious diseases. Thus, the aim of this study was to evaluate for the first time the in vitro antimicrobial activity and brine shrimp lethality of extracts and isolated compounds from Zeyheria tuberculosa (Vell.) Bur., a species used in Brazilian folk medicine for treatment of cancer and skin diseases.

Author(s): 
Bastos, Maria Lysete A.
Lima, Maria Raquel F.
Conserva, Lucia M.
Andrade, Vânia S.
Rocha, Eliana M. M.
Lemos, Rosangela P. L.
Publication Title: 
Biological & Pharmaceutical Bulletin

Kaempferia parviflora (KP), a Zingiberaceae plant, is used as a folk medicine in Thailand for the treatment of various symptoms, including general pains, colic gastrointestinal disorders, and male impotence. In this study, the inhibitory activities of KP against xanthine oxidase (XOD) were investigated. The extract of KP rhizomes showed more potent inhibitory activity (38% at 500 µg/ml) than those of the other Zingiberaceae plants tested.

Author(s): 
Nakao, Kikuyo
Murata, Kazuya
Deguchi, Takahiro
Itoh, Kimihisa
Fujita, Takanori
Higashino, Masayuki
Yoshioka, Yuri
Matsumura, Shin-Ichi
Tanaka, Rika
Shinada, Tetsuro
Ohfune, Yasufumi
Matsuda, Hideaki
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Many natural products used in preventive medicine have also been developed as cosmeceutical ingredients in skin care products, such as Scutellaria baicalensis and Gardenia jasminoides. Norartocarpetin is one of the antioxidant and antityrosinase activity compound in Artocarpus communis; however, the cytotoxicity, skin irritation and antimelanogenesis mechanisms of norartocarpetin have not been investigated yet. METHODS: In the present study, cell viability in vitro and skin irritation in vivo are used to determine the safety of norartocarpetin.

Author(s): 
Ko, Horng-Huey
Tsai, Yi-Ting
Yen, Ming-Hong
Lin, Chun-Ching
Liang, Chan-Jung
Yang, Tsung-Han
Lee, Chiang-Wen
Yen, Feng-Lin
Publication Title: 
Circulation

BACKGROUND: The development of atrium-selective antiarrhythmic agents is a current strategy for inhibiting atrial fibrillation (AF). The present study investigated whether the natural flavone acacetin from the traditional Chinese medicine Xuelianhua would be an atrium-selective anti-AF agent. METHODS AND RESULTS: The effects of acacetin on human atrial ultrarapid delayed rectifier K(+) current (I(Kur)) and other cardiac ionic currents were studied with a whole-cell patch technique.

Author(s): 
Li, Gui-Rong
Wang, Hong-Bing
Qin, Guo-Wei
Jin, Man-Wen
Tang, Qiang
Sun, Hai-Ying
Du, Xin-Ling
Deng, Xiu-Ling
Zhang, Xiao-Hua
Chen, Jing-Bo
Chen, Lei
Xu, Xiao-Hui
Cheng, Lik-Cheung
Chiu, Shui-Wah
Tse, Hung-Fat
Vanhoutte, Paul M.
Lau, Chu-Pak

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