Publication Title: 
Journal of Pharmaceutical and Biomedical Analysis

Drug discovery from complex mixture like Chinese herbs is a challenge and extensive false positives make the obtainment of specific bioactive compounds difficult. In the present study, a novel sample preparation method was proposed to rapidly reveal the specific bioactive compounds from complex mixtures using ?-glucosidase as a case. Firstly, aqueous and methanol extracts of 500 traditional Chinese medicines were carried out with the aim of finding new sources of ?-glucosidase inhibitors.

Li, D. Q.
Zhao, J.
Xie, J.
Li, S. P.
Publication Title: 
PloS One

Pollinator behaviour directly affects patterns of pollen movement and outcrossing rates in plants. In orchids pollinated by sexual deception of insects, patterns of pollen movement are primarily determined by the mate-searching behaviour of the deceived males. Here, using a capture-mark-recapture study (CMR) and dietary analysis, we compare mate-searching behaviour in relation to local abundance of two pollinator species and explore the implications for pollen movement in sexually deceptive Drakaea (Orchidaceae). Drakaea are pollinated solely by the sexual deception of male thynnine wasps.

Menz, Myles H. M.
Phillips, Ryan D.
Dixon, Kingsley W.
Peakall, Rod
Didham, Raphael K.
Publication Title: 
Plant Physiology

The relationship between the transition to budding and flowering in Artemisia annua and the production of the antimalarial sesquiterpene, artemisinin (AN), the dynamics of artemisinic metabolite changes, AN-related transcriptional changes, and plant and trichome developmental changes were measured. Maximum production of AN occurs during full flower stage within floral tissues, but that changes in the leafy bracts and nonbolt leaves as the plant shifts from budding to full flower.

Arsenault, Patrick R.
Vail, Daniel
Wobbe, Kristin K.
Erickson, Karen
Weathers, Pamela J.
Publication Title: 
Malaria Journal

BACKGROUND: Artemisinin is the current drug of choice for treatment of malaria and a number of other diseases. It is obtained from the annual herb, Artemisia annua and some microbial sources by genetic engineering. There is a great concern that the artemisinin production at current rate will not meet the increasing demand by the pharmaceutical industry, so looking for additional sources is imperative.

Mannan, Abdul
Ahmed, Ibrar
Arshad, Waheed
Asim, Muhammad F.
Qureshi, Rizwana A.
Hussain, Izhar
Mirza, Bushra
Publication Title: 
Current Opinion in Plant Biology

Cytochromes P450 catalyze a broad range of regiospecific, stereospecific and irreversible steps in the biosynthetic routes of plant natural metabolites with important applications in pharmaceutical, cosmetic, fragrance and flavour, or polymer industries. They are consequently essential drivers for the engineered bioproduction of such compounds. Two ground-breaking developments of commercial products driven by the engineering of P450s are the antimalarial drug precursor artemisinic acid and blue roses or carnations. Tedious optimizations were required to generate marketable products.

Renault, Hugues
Bassard, Jean-Etienne
Hamberger, Björn
Werck-Reichhart, Danièle
Publication Title: 
Complementary Therapies in Clinical Practice

Episiotomy is the most common perineal incision in obstetric and midwifery. Nowadays alternative and complementary methods such as Aromatherapy using essential oils are established as an alternative therapy. This research was carried out to assess the effect of lavender oil in wound healing. This randomized control trial was conducted on 120 primiparous women with singleton pregnancy, without any acute and chronic disease and allergy who had undergone normal spontaneous vaginal delivery and episiotomy. They were randomly allocated in case and control groups.

Vakilian, Katayon
Atarha, Mahtab
Bekhradi, Reza
Chaman, Reza
Publication Title: 
Revista Medico-Chirurgical?? a Societ????ii De Medici ??i Naturali??ti Din Ia??i

AIM: In this paper, we studied comparatively volatile fractions obtained by hydrodistillation from 5 samples of lavender flowers (L. angustifolia ssp. angustifolia, L. hybrida, L. angustifolia spp. pyrenaica, L. angustifolia spp. angustifolia cv. Munstead and cv. Hidcote blue) cultivated during 2009 in the Botanical Garden from Galati. MATERIAL AND METHODS: The essential oils have been characterized using gas-chromatography and mass spectroscopy analysis (GC-MS).

Robu, Silvia
Aprotosoaie, Ana Clara
Spac, A.
Cioanc?, Oana
H?ncianu, Monica
St?nescu, Ursula
Publication Title: 
Indian Journal of Biochemistry & Biophysics

Invertase (beta-fructofuranosidase, EC was purified from the flowers of Woodfordia fruticosa, which is used to prepare certain fermented Ayurvedic drugs. The enzyme was purified to near homogeneity as judged by native PAGE with a yield of 10.7%, using (NH4)2SO4 fractionation, followed by gel filtration through Sepharose 4B and DEAE cellulose chromatography at pH 6.8 and 4.42. The molecular mass of the purified enzyme as determined by elution through Sepharose 4B gel column was found to be approximately 280 kDa.

Weersaooriya, M. K. B.
Yatawara, H. P.
Publication Title: 
Journal of Ethnopharmacology

Nymphaea stellata willd., a medicinal plant mentioned in Ayurveda for the treatment of liver disorders, has not been subjected to systematic scientific investigations to asses its hepatoprotective effects. Therefore, the present study was undertaken to investigate the hepatoprotective activity of extract of Nymphaea stellata willd., flower against carbon tetrachloride-induced hepatic damage in albino rats.

Bhandarkar, Manoj R.
Khan, Aqueel
Publication Title: 
Journal of Periodontology

BACKGROUND: This study evaluated the inhibitory activity of triphala on PMN-type matrix metalloproteinase (MMP-9) expressed in adult periodontitis patients and compared its activity with another ayurvedic drug, kamillosan, and doxycycline, which has known inhibitory activity. METHODS: Matrix metalloproteinases (MMPs) were extracted from gingival tissue samples from 10 patients (six males, four females) with chronic periodontitis.

Abraham, Sajith
Kumar, M. Senthil
Sehgal, P. K.
Nitish, S.
Jayakumar, N. D.


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