Fluorocarbons

Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Carbon tetrachloride (CCl4) is a well-known hepatotoxin and exposure to this chemical is known to induce oxidative stress and causes liver injury by the formation of free radicals. Acute and chronic renal damage are also very common pathophysiologic disturbances caused by CCl4.

Author(s): 
Manna, Prasenjit
Sinha, Mahua
Sil, Parames C.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Carbon tetrachloride (CCl4) is a well-known hepatotoxin and exposure to this chemical is known to induce oxidative stress and causes liver injury by the formation of free radicals. Acute and chronic renal damage are also very common pathophysiologic disturbances caused by CCl4.

Author(s): 
Manna, Prasenjit
Sinha, Mahua
Sil, Parames C.
Publication Title: 
Journal of Magnetic Resonance (San Diego, Calif.: 1997)

For mass-limited samples, the residual sample volume outside the detection coil is an important concern, as is good base line resolution. Here, we present the construction and evaluation of magnetic susceptibility-matched plugs for microcoil NMR sample cells which address these issues. Mixed-epoxy glue and ultem tube plugs that have susceptibility values close to those of perfluorocarbon FC-43 (fluorinert) and copper were used in small volume (0.5-2 microL) and larger volume (15-20 microL) thin glass capillary sample cells. Using these plugs, the sample volume efficiency (i.e.

Author(s): 
Kc, Ravi
Gowda, Yashas N.
Djukovic, Danijel
Henry, Ian D.
Park, Gregory H. J.
Raftery, Daniel
Publication Title: 
American Journal of Epidemiology

Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are persistent environmental contaminants that affect metabolic regulation, inflammation, and other factors implicated in the pathogenesis of osteoarthritis (OA). However, the link between these compounds and OA remains unknown. In this study, the authors investigated the association of OA with PFOA and PFOS in a population of 49,432 adults from 6 PFOA-contaminated water districts in the mid-Ohio Valley (2005-2006).

Author(s): 
Innes, Kim E.
Ducatman, Alan M.
Luster, Michael I.
Shankar, Anoop
Publication Title: 
Journal of Immunotoxicology

Perfluoroalkyl substances (PFAS) are suggested to have immunosuppressive effects; exposure in utero and in the first years of life is of special concern as fetuses and small children are highly vulnerable to toxicant exposure. The objective of this study was to investigate the effect of pre-natal exposure to PFAS on responses to pediatric vaccines and immune-related health outcomes in children up to 3 years of age.

Author(s): 
Granum, Berit
Haug, Line S.
Namork, Ellen
Stølevik, Solvor B.
Thomsen, Cathrine
Aaberge, Ingeborg S.
van Loveren, Henk
Løvik, Martinus
Nygaard, Unni C.
Publication Title: 
Comparative biochemistry and physiology. Toxicology & pharmacology: CBP

Rainbow trout (Oncorhynchus mykiss) are an outstanding model of liver cancer induction by environmental chemicals and development of strategies for chemoprevention. Trout have critical and unique advantages allowing for cancer studies with 40,000 animals to determine dose-response at levels orders of magnitude lower than possible in rodents. Examples of two promoters in this model, the dietary supplement dehydroepiandrosterone (DHEA) and industrial chemical perfluorooctanoic acid (PFOA), are presented.

Author(s): 
Williams, David E.
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