Fluoroquinolones

Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: There has been renewal of interest in the use of prophylactic antibiotics to reduce the frequency of exacerbations and improve quality of life in chronic obstructive pulmonary disease (COPD). OBJECTIVES: To determine whether or not regular treatment of COPD patients with prophylactic antibiotics reduces exacerbations or affects quality of life. SEARCH METHODS: We searched the Cochrane Airways Group Trials Register and bibliographies of relevant studies. The latest literature search was August 2013.

Author(s): 
Herath, Samantha C.
Poole, Phillippa
Publication Title: 
The Japanese Journal of Antibiotics

General pharmacological effects of T-3761, a new oral quinolone antibacterial agent, on the central nervous system were investigated in laboratory animals. The results obtained are summarized as follows. 1. T-3761 exerted no significant effects on spontaneous motor activity, motor coordination, pentobarbital-induced hypnosis, electroshock-, pentetrazole- or strychnine-induced convulsion, acetic acid-induced writhing responses, reserpine-induced hypothermia and ptosis in mice at oral doses of 100, 300 and 1,000 mg/kg.

Author(s): 
Furuhata, K.
Hiraiwa, T.
Ono, S.
Tanaka, K.
Shimotori, T.
Makino, S.
Kitamura, K.
Aikawa, Y.
Izumi, Y.
Kimura, T.
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