Fluorouracil

Publication Title: 
Anticancer Research

Artemisinin (AR) is a widely used antimalarial drug. Recently, additional uses for AR as an anticancer drug were discovered. Using TUNEL, immunohistochemistry (IHS) markers and flow cytometry techniques, we evaluated the effect of AR and 5-FU on HPV 16 immortalized and transformed human gingival epithelial (IHGK) cells. The results of TUNEL showed that AR-treated IHGK cells consisted of 82% positive cells, while 5-FU-treated cells consisted of 18% positive cells.

Author(s): 
Yamachika, Eiki
Habte, Temesgen
Oda, Dolphine
Publication Title: 
Asian Pacific journal of cancer prevention: APJCP

Cytotoxic activity of artemisinin and derivatives in the presence and absence of holo-transferrin and expression of genes involved in resistance of cancer cells were investigated in human cholangiocarcinoma (CL-6) and hepatocarcinoma (Hep-G2) cell lines in vitro. After incubation with the test drugs and 5-fluorouracil (5-FU) cytotoxicity was asessed by MTT assay.

Author(s): 
Chaijaroenkul, Wanna
Viyanant, Vithoon
Mahavorasirikul, Wiratchanee
Na-Bangchang, Kesara
Publication Title: 
Cancer Chemotherapy and Pharmacology

PURPOSE: Panax notoginseng is a commonly used Chinese herb. Although a few studies have found that notoginseng shows anti-tumor effects, the effect of this herb on colorectal cancer cells has not been investigated. 5-Fluorouracil (5-FU) is a chemotherapeutic agent for the treatment of colorectal cancer that interferes with the growth of cancer cells. However, this compound has serious side effects at high doses.

Author(s): 
Wang, Chong-Zhi
Luo, Xiaoji
Zhang, Bin
Song, Wen-Xin
Ni, Ming
Mehendale, Sangeeta
Xie, Jing-Tian
Aung, Han H.
He, Tong-Chuan
Yuan, Chun-Su
Publication Title: 
Anticancer Research

PHY906 is a Chinese medicine formula with claims for the treatment of severe gastrointestinal distress. PHY906 enhanced the therapeutic index of various chemotherapeutic agents in human hepatocellular carcinoma xenografts. Accordingly, here a phase I/II clinical study was conducted with the combination of capecitabine in patients with advanced, unresectable hepatocellular carcinoma. More than 60% of patients had either stable disease or better after two treatment cycles. Median overall survival was 9.2 months.

Author(s): 
Yen, Yun
So, Samuel
Rose, Michal
Saif, M. Wasif
Chu, Edward
Liu, Shwu-Huey
Foo, Angeline
Jiang, Zaoli
Su, Tahmun
Cheng, Yung-Chi
Publication Title: 
Oncogene

Claudin-2 is a unique member of the claudin family of transmembrane proteins, as its expression is restricted to the leaky epithelium in vivo and correlates with epithelial leakiness in vitro. However, recent evidence suggests potential functions of claudin-2 that are relevant to neoplastic transformation and growth. In accordance, here we report, on the basis of analysis of mRNA and protein expression using a total of 309 patient samples that claudin-2 expression is significantly increased in colorectal cancer and correlates with cancer progression.

Author(s): 
Dhawan, P.
Ahmad, R.
Chaturvedi, R.
Smith, J. J.
Midha, R.
Mittal, M. K.
Krishnan, M.
Chen, X.
Eschrich, S.
Yeatman, T. J.
Harris, R. C.
Washington, M. K.
Wilson, K. T.
Beauchamp, R. D.
Singh, A. B.
Publication Title: 
Cell Death & Disease

Falcarindiol (FAD) is a natural polyyne with various beneficial biological activities. We show here that FAD preferentially kills colon cancer cells but not normal colon epithelial cells. Furthermore, FAD inhibits tumor growth in a xenograft tumor model and exhibits strong synergistic killing of cancer cells with 5-fluorouracil, an approved cancer chemotherapeutic drug. We demonstrate that FAD-induced cell death is mediated by induction of endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR).

Author(s): 
Jin, H. R.
Zhao, J.
Zhang, Z.
Liao, Y.
Wang, C.-Z.
Huang, W.-H.
Li, S.-P.
He, T.-C.
Yuan, C.-S.
Du, W.
Publication Title: 
Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie

OBJECTIVE: To determine the prevalence of tearing and canalicular fibrosis in patients receiving systemic 5-fluorouracil (5-FU) therapy and the reversibility of the symptoms when treatment is stopped. DESIGN: Prospective study. SETTING: University-affiliated tertiary care hospital in Toronto. PATIENTS: Thirty patients (17 men and 13 women aged 38 to 81 years) with advanced gastrointestinal carcinoma receiving intravenous 5-FU therapy as palliative (weekly) treatment (20 patients) or adjunctive (cycle) treatment (10 patients).

Author(s): 
Hassan, A.
Hurwitz, J. J.
Burkes, R. L.
Publication Title: 
JOP: Journal of the pancreas

One of the greatest challenges in the treatment of pancreatic cancer remains its inherent lack of beneficial response to cytotoxic chemotherapy. According to the encyclopedic knowledge on herbal medicine regimen and clinical experience accumulated for centuries, traditional Chinese medicine can provide new avenues for alternative treatments of pancreatic diseases. Chinese herbal extracts have been widely used for the treatment of various cancers, but objective information on their efficacy in pancreatic cancer is lacking.

Author(s): 
Saif, Muhammad Wasif
Publication Title: 
Chinese Journal of Cancer

Either cetuximab or bevacizumab can improve the survival of patients with metastastic colorectal cancer (mCRC) if administered combided with cytotoxic agents. However, the effect of two or more target agents in combination is uncertain in these patients. Here, we reported a patient with mCRC successfully treated by a combination of target agents after the failure of chemotherapy.

Author(s): 
Xia, Liang-Ping
Wu, Pei-Hong
Xia, Jian-Chuan
Zhang, Bei
Guan, Zhong-Zhen
Wan, De-Sen
Guo, Gui-Fang
Zeng, Yi-Xin
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Colorectal cancer remains one of the leading causes of cancer death worldwide. Traditional Chinese Medicine (TCM) has played a positive role in colorectal cancer treatment. There is a great need to establish effective herbal formula for colorectal cancer treatment. Based on TCM principles and clinical practices, we have established an eight herbs composed formula for colorectal cancer treatment, which is Teng-Long-Bu-Zhong-Tang (TLBZT). We have demonstrated the anticancer effects of TLBZT against colorectal carcinoma in vitro.

Author(s): 
Deng, Shan
Hu, Bing
An, Hong-Mei
Du, Qin
Xu, Ling
Shen, Ke-Ping
Shi, Xiu-Feng
Wei, Meng-Meng
Wu, Yang

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