Adult voles show sexual differences in their behavioral responses to estrogen. To determine whether this sexual dimorphism is related to early androgen exposure as it is in other rodents, female voles were treated neonatally with testosterone. In addition, males were castrated neonatally or treated perinatally with either the antiandrogen, flutamide or with the antiaromatase, ATD. When androgenized females were treated with estrogen in adulthood, they exhibited normal sexual behaviors.
Journal of Manipulative and Physiological Therapeutics
OBJECTIVE: To present a case in which the initial diagnosis of spinal metastasis secondary to prostate cancer was established from findings of the digital rectal examination (DRE) and serum prostate-specific antigen (PSA) analysis. CLINICAL FEATURES: A 79-yr-old black male was seen after suffering from low back pain for 1 month. Urinary frequency and nocturia were associated symptoms. Abnormal findings on the DRE and serum PSA determination suggested a preliminary diagnosis of spinal metastases secondary to prostate cancer.