Foreskin

Publication Title: 
Molecular Carcinogenesis

The Id family of helix-loop-helix transcription factors is upregulated in a variety of human malignancies and has been implicated in promoting tumorigenesis through effects on cell growth, differentiation, and tumor angiogenesis. While expression of Id proteins has been associated with tumorigenesis, the precise mechanistic relationship between Id expression and carcinogenesis has not been clearly delineated. We have previously shown that Id1 delays cellular senescence in primary mammalian cells through inhibition of the cell cycle regulatory protein and familial melanoma gene, p16/INK4a.

Author(s): 
Cummings, Staci D.
Ryu, Byungwoo
Samuels, Michael A.
Yu, Xiaobing
Meeker, Alan K.
Healey, Megan A.
Alani, Rhoda M.
Publication Title: 
Experimental Dermatology

Delphinidin (Del), [3,5,7,3'-,4'-,5'-hexahydroxyflavylium], an anthocyanidin and a potent antioxidant abundantly found in pigmented fruits and vegetables exhibits proapoptotic effects in many cancer cells. Here, we determined the effect of Del on growth, apoptosis and differentiation of normal human epidermal keratinocytes (NHEKs) in vitro in submerged cultures and examined its effects in a three-dimensional (3D) epidermal equivalent (EE) model that permits complete differentiation reminiscent of in vivo skin.

Author(s): 
Chamcheu, Jean Christopher
Afaq, Farrukh
Syed, Deeba N.
Siddiqui, Imtiaz A.
Adhami, Vaqar M.
Khan, Naghma
Singh, Sohinderjit
Boylan, Brendan T.
Wood, Gary S.
Mukhtar, Hasan
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