Frail Elderly

Publication Title: 
Lancet (London, England)

The first International Consultation on Incontinence was held under the auspices of WHO in 1998. The multidisciplinary consultation covered anatomy, physiology, pathology, and the investigation and management of incontinent individuals. Because incontinence is a prevalent global disease, the consultation was mindful of the need to make its recommendations applicable in all health-care systems.

Publication Title: 
Recenti Progressi in Medicina

The 20th century will be remembered for its technological and scientific discoveries and for the exceptional changes in the demographic structure brought about by these and the improved economic and social conditions; in fact, the reduction in the birth rate and a fall in the death rate have caused an increase in the population of the elderly.

Author(s): 
Cicconetti, Paolo
Riolo, Noemi
Ettorre, Evaristo
Costarella, Marianna
Priami, Carolina
Marigliano, Vincenzo
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

BACKGROUND: Centenarians are sometimes said to be representative of lifelong healthy aging. Whether they are, in fact, examples of healthy aging remains a subject of debate. The existence of heterogeneity in functional status has been reported repeatedly in previous studies of centenarians. However, there is as yet no standardized classification system with which to describe their functional phenotype. METHODS: As part of a dynamic cohort study, we studied 304 centenarians (65 men and 239 women) living in Tokyo.

Author(s): 
Gondo, Yasuyuki
Hirose, Nobuyoshi
Arai, Yasumichi
Inagaki, Hiroki
Masui, Yukie
Yamamura, Ken
Shimizu, Ken-ichirou
Takayama, Michiyo
Ebihara, Yoshinori
Nakazawa, Susumu
Kitagawa, Koji
Publication Title: 
Age and Ageing

INTRODUCTION: parental age at conception may affect life expectancy. Adult daughters of older fathers seem to live shorter lives and, in one study, being born to a mother aged <25 was an important predictor of exceptional longevity. The effect of parental age on fitness/frailty in late life is unknown. We aimed to investigate the relationships between parental age and frailty and longevity in older adults. METHODS: in the Canadian Study of Health and Aging (CSHA), data was collected on individuals aged >or=65 using a Self-Assessed Risk Factor Questionnaire and screening interview.

Author(s): 
Hubbard, Ruth E.
Andrew, Melissa K.
Rockwood, Kenneth
Publication Title: 
Newsweek
Author(s): 
Cowley, G.
Publication Title: 
The Journal of Nutrition, Health & Aging

The relationship of nutrient intakes to life expectancies in Japan since the Second World War has demonstrated that sufficient intakes of animal protein and fat are crucial for attaining longevity. In the community dwelling elderly, the higher the serum albumin was, the longer the further life expectancy in the elderly. Serum total cholesterol showed a U-shape relationship to further life expectancies in the elderly. Low serum cholesterol was deleterious for higher levels of functional capacity.

Author(s): 
Shibata, H.
Publication Title: 
La Revue Du Praticien
Author(s): 
Belmin, JoÎl
Konrat, CÈcile
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Author(s): 
Kahn, Arnold J.
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Despite the fact that growth hormone (GH) has not been approved for antiaging purposes, its use for this indication is widespread and increasing. The Growth Hormone Research Society (GRS) convened an international workshop to critically review and debate the available evidence related to the use of GH in the older adults and the relationship between the GH/insulin-like growth factor I (IGF-I) axis and the aging process.

Author(s): 
Thorner, Michael O.
Publication Title: 
Biogerontology

The pivotal role played by zinc-gene interaction in affecting the inflammatory response mediated by IL-6 in ageing, successful ageing (nonagenarians) and the most common age-related diseases is now recognized. Contradictory data emerging from association studies of IL-6 polymorphisms with longevity and chronic age-related diseases seem to arise from the interaction of this inflammatory pathway with dietary habits. Similar conclusions are expected to arise from association studies with the frailty syndrome.

Author(s): 
Mocchegiani, Eugenio
Basso, Andrea
Giacconi, Robertina
Piacenza, Francesco
Costarelli, Laura
Pierpaoli, Sara
Malavolta, Marco

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