Freund's Adjuvant

Publication Title: 
Phytotherapy research: PTR

In the present study, attempts have been made to evaluate the antiarthritic effect of the Indian Ayurvedic herbal formulation Triphala on adjuvant-induced arthritis in mice and to compare it with that of the non-steroidal antiinflammatory drug indomethacin. Arthritis was induced by intradermal injection of complete Freund's adjuvant (0.1 mL) into the right hind paw of Swiss albino mice. Triphala (1 g/kg/bxwt) and indomethacin (3 mg/kg/bxwt) were administered orally for 8 days (from day 11 to 18) after adjuvant injection.

Author(s): 
Rasool, M.
Sabina, E. P.
Publication Title: 
Toxicon: Official Journal of the International Society on Toxinology

The Indian Monocellate Cobra venom (NKV) showed anti-arthritic activity over FCA induced arthritis in male albino rats. NKV treatment (1/20th & 1/10th MLD doses x 13 days, i.p.) showed significant restoration in paw & ankle volume, paw weight. Urinary hydroxyproline, glucosamine, serum ACP, ALP and IL-10 level were restored significantly, due to NKV treatment, as compared with arthritic rats. NKV also showed significant protection against arthritis induced oxidative damages.

Author(s): 
Gomes, Antony
Bhattacharya, Sourav
Chakraborty, Mousumi
Bhattacharjee, Pushpak
Mishra, Roshnara
Gomes, Aparna
Publication Title: 
Immunopharmacology and Immunotoxicology

The present study was aimed to establish the efficacy of Jeevaneeya Rasayana (JR), an ayurvedic polyherbal formulation, in adjuvant-induced arthritic (AIA) rat model with reference to mediators of inflammation. The methanolic (MJR), ethanolic (EJR), and water extracts (WJR) of JR were prepared and their anti-inflammatory activity in carrageenan-induced acute model was evaluated. MJR at a dose of 25 mg/kg showed significantly higher anti-inflammatory effect than EJR, WJR, and standard drug diclofenac. MJR also significantly decreased the paw edema in AIA rats.

Author(s): 
Shyni, G. L.
Ratheesh, M.
Sindhu, G.
Helen, A.
Publication Title: 
Journal of Basic and Clinical Physiology and Pharmacology

Premna corymbosa (Burm.f.) Rottl. & Willd. (Verbenaceae) is a small tree used in traditional medicine for rheumatic disorders and it is the one of the ingredient in many ayurvedic preparations available in the market for inflammatory disorder uses. The aim of this work was to evaluate the acute toxicity and anti-arthritic activity of P. corymbosa ethanolic extract (PCEE) in experimental animals. In the acute toxicity study, a single dose of PCEE, 2000 mg kg(-1) body weight p.o., was administered.

Author(s): 
Karthikeyan, M.
Deepa, K.
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Terminalia paniculata Roxb. (Family-Combretaceae) is a wild tree commonly used in traditional ayurvedic medicine for the treatment of inflammation of parotid glands and in menstrual disorders. AIM OF THE STUDY: To explore the folk use of Terminalia paniculata on pharmacological grounds to evaluate the scientific basis of anti-inflammatory activity.

Author(s): 
Talwar, Sahil
Nandakumar, K.
Nayak, Pawan G.
Bansal, Punit
Mudgal, Jayesh
Mor, Vijay
Rao, Chamallamudi Mallikarjuna
Lobo, Richard
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Mesua ferrea Linn. (Cluciaseae), Cobra's saffron, is named after the heaviness of its timber and is cultivated in tropical climates for its form, foliage, and fragrant flowers. It is prescribed in the Ayurvedic literature for the treatment of pain, inflammation, and rheumatic conditions. OBJECTIVE: In present investigation, activity of Mesua ferrea and its evaluation in the formaldehyde and Complete Freund's Adjuvant (CFA)-induced arthritis in rats is reported.

Author(s): 
Jalalpure, Sunil S.
Mandavkar, Yuvaraj D.
Khalure, Pallavi R.
Shinde, Gulab S.
Shelar, Pournima A.
Shah, Amol S.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

BACKGROUND: Acupuncture has traditionally been used in China and is being increasingly applied in Western countries to treat a variety of conditions, including inflammatory disease. However, clinical trials investigating the effectiveness of the anti-inflammatory effects of acupuncture have yielded inconsistent results, and the underlying mechanisms of acupuncture-produced anti-inflammation are unclear. OBJECTIVE: To evaluate the effectiveness of electroacupuncture (EA) on inflammation in a rat model.

Author(s): 
Zhang, Rui-Xin
Lao, Lixing
Wang, Xiaoya
Fan, Arthur
Wang, Linbo
Ren, Ke
Berman, Brian M.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVE: Ruxiang, or Gummi olibanum, an herbal medicine derived from the gum resin of Boswellia carterii Birdw. (BC) of the family Burseraceae, has been used traditionally in China to alleviate pain and reduce inflammation. The present study is an investigation of the effects of a BC extract on persistent hyperalgesia and edema in rats with peripheral inflammation. DESIGN: In this randomized, blinded study, the antihyperalgesic and antiedema effects of 3 dosages of BC were compared to a vehicle control.

Author(s): 
Fan, Arthur Yin
Lao, Lixing
Zhang, Rui-Xin
Wang, Lin-Bo
Lee, David Y.-W.
Ma, Zhong-Ze
Zhang, Wu-Yan
Berman, Brian
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Electroacupuncture (EA) has been reported to produce anti-edema and anti-hyperalgesia effects on inflammatory disease. However, the mechanisms are not clear. The present study investigated the biochemical mechanisms of EA anti-inflammation in a rat model. METHODS: Three experiments were conducted on male Sprague-Dawley rats (n = 7-8/per group). Inflammation was induced by injecting complete Freund's adjuvant (CFA) subcutaneously into the plantar surface of one hind paw. Experiment 1 measured plasma corticosterone (CORT) levels to see if EA regulates CORT secretion.

Author(s): 
Li, Aihui
Zhang, Rui-Xin
Wang, Yi
Zhang, Haiqing
Ren, Ke
Berman, Brian M.
Tan, Ming
Lao, Lixing
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Studies show that electroacupuncture (EA) has beneficial effects in patients with inflammatory diseases. This study investigated the mechanisms of EA anti-inflammation, using a rat model of complete Freund's adjuvant (CFA)-induced hind paw inflammation and hyperalgesia. DESIGN: Four experiments were conducted on male Sprague-Dawley rats (n = 6-7/per group). Inflammation was induced by injecting CFA into the plantar surface of one hind paw. Experiment 1 examined whether EA increases plasma adrenocorticotropic hormone (ACTH) levels.

Author(s): 
Li, Aihui
Lao, Lixing
Wang, Yi
Xin, Jiajia
Ren, Ke
Berman, Brian M.
Tan, Ming
Zhang, Ruixin

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