Furans

Publication Title: 
Archives Internationales De Pharmacodynamie Et De Thérapie
Author(s): 
Tsujimoto, A.
Doi, T.
Ikeda, M.
Nishikawa, T.
Publication Title: 
Brain Research

Bilobalide, a constituent of Ginkgo biloba, has neuroprotective properties. Its mechanism of action is unknown but it was recently found to block GABA(A) receptors. The goal of this study was to test the potential role of a GABAergic mechanism for the neuroprotective activity of bilobalide. In rat hippocampal slices exposed to NMDA, release of choline indicates breakdown of membrane phospholipids. NMDA-induced choline release was almost completely blocked in the presence of bilobalide (10 microM) and under low-chloride conditions.

Author(s): 
Kiewert, Cornelia
Kumar, Vikas
Hildmann, Oksana
Rueda, Misty
Hartmann, Joachim
Naik, Runa S.
Klein, Jochen
Publication Title: 
Stroke; a Journal of Cerebral Circulation

BACKGROUND AND PURPOSE: Ginkgo biloba extracts are now prescribed in several countries for their reported health benefits, particularly for medicinal properties in the brain. The standardized Ginkgo extract, EGb761, has been reported to protect neurons against oxidative stress, but the underlying mechanisms are not fully understood. METHODS: To characterize the oral consumption of EGb761 in transient ischemia, we performed the middle cerebral artery occlusion (MCAO) filament model in wild-type and heme oxygenase 1 (HO-1) knockouts.

Author(s): 
Saleem, Sofiyan
Zhuang, Hean
Biswal, Shyam
Christen, Yves
Doré, Sylvain
Publication Title: 
BMC neuroscience

BACKGROUND: Dysfunctions in the serotonergic system have been implicated in several neurological disorders such as depression. Elderly individuals who have been diagnosed with clinical depression show elevated cases of neurodegenerative diseases. This has led to suggestions that modulating the serotonin (5-HT) system could provide an alternative method to current therapies for alleviating these pathologies. The neuroprotective effects of bilobalide in vitro have been documented. We aim to determine whether bilobalide affects the 5-HT system in the nematode C. elegans.

Author(s): 
Brown, Marishka K.
Luo, Yuan
Publication Title: 
Brain Research

Neuroprotective properties of bilobalide, a specific constituent of Ginkgo extracts, were tested in a mouse model of stroke. After 24h of middle cerebral artery occlusion (MCAO), bilobalide reduced infarct areas in the core region (striatum) by 40-50% when given at 10mg/kg 1h prior to MCAO. Neuroprotection was also observed at lower doses, or when the drug was given 1h past stroke induction. Sensorimotor function in mice was improved by bilobalide as shown by corner and chimney tests.

Author(s): 
Lang, Dorothee
Kiewert, Cornelia
Mdzinarishvili, Alexander
Schwarzkopf, Tina Maria
Sumbria, Rachita
Hartmann, Joachim
Klein, Jochen
Publication Title: 
Magnetic resonance in chemistry: MRC

The complete and unambiguous (1)H NMR assignments of ten marker constituents of Ginkgo biloba are described. The comprehensive (1)H NMR profiles (fingerprints) of ginkgolide A, ginkgolide B, ginkgolide C, ginkgolide J, bilobalide, quercetin, kaempferol, isorhamnetin, isoquercetin, and rutin in DMSO-d(6) were obtained through the examination of 1D (1)H NMR and 2D (1)H,(1)H-COSY data, in combination with (1)H iterative full spin analysis (HiFSA).

Author(s): 
Napolitano, José G.
Lankin, David C.
Chen, Shao-Nong
Pauli, Guido F.
Publication Title: 
Regulatory toxicology and pharmacology: RTP

Homeopathy is a world-wide available form of complementary therapy, which has a tradition of 200years. Due to the long history of clinical use, i.e. reflected by the first edition of the Homeopathic Pharmacopoeia of the US of 1914, the conduct of toxicological studies is not required if the safety has been otherwise substantiated. The aim of this article is to establish a risk assessment procedure without full toxicological examination, using homeopathic preparations from Pulsatilla pratensis L. as an example.

Author(s): 
Schrenk, D.
Merz, K.-H.
Jochims, K.
Publication Title: 
Biological & Pharmaceutical Bulletin

This study was designed to investigate the effect of sesaminol glycosides (SG), one of the most abundant lignan glycosides in sesame (Sesamum indicum LINN.) seed, on cognitive deficits and oxidative stress induced by intracerebroventricular (i.c.v.) injection of beta-amyloid protein (Abeta)(25-35) in mice. Mice were fed diets containing 0%, 0.25%, or 0.5% of SG for six weeks. Dietary SG showed a protective effect against Abeta-induced learning and memory deficits in passive avoidance and the Morris water maze test.

Author(s): 
Um, Min Young
Ahn, Ji Yun
Kim, Suna
Kim, Mi Kyung
Ha, Tae Youl
Publication Title: 
Chinese Medical Journal

BACKGROUND: There is increasing interest in the role of dietary factors in both the development and behaviour of prostate cancer. This study was carried out to evaluate the impact of the dietary factor lycopene on DNA synthesis, activity and expression of the androgen receptor gene element in prostate LnCaP cells and to report our pilot phase II study investigating its effect on prostate-specific antigen velocity over one year. METHODS: LnCaP cells were grown with or without different concentrations of lycopene or tetrahydrofuran (THF solvent) added to the culture medium for 48 hours.

Author(s): 
Zhang, Xin
Wang, Qi
Neil, Barber
Chen, Xiao
Publication Title: 
Chinese Medical Journal

BACKGROUND: There is increasing interest in the role of dietary factors in both the development and behaviour of prostate cancer. This study was carried out to evaluate the impact of the dietary factor lycopene on DNA synthesis, activity and expression of the androgen receptor gene element in prostate LnCaP cells and to report our pilot phase II study investigating its effect on prostate-specific antigen velocity over one year. METHODS: LnCaP cells were grown with or without different concentrations of lycopene or tetrahydrofuran (THF solvent) added to the culture medium for 48 hours.

Author(s): 
Zhang, Xin
Wang, Qi
Neil, Barber
Chen, Xiao

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