G1 Phase Cell Cycle Checkpoints

Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Plants are the valuable source of natural products with important medicinal properties. Most of the approved anti cancer drugs have a natural product origin or are natural products. Retinoblastoma is the most common ocular cancer of children. Although chemotherapy is the preferred mode of therapy, a successful treatment for retinoblastoma requires enucleation. Chebulagic acid (CA) from Terminalia chebula was shown to have anti-proliferative properties in the studies on cancerous cell lines.

Author(s): 
Kumar, Naresh
Gangappa, D.
Gupta, Geetika
Karnati, Roy
Publication Title: 
Cell Cycle (Georgetown, Tex.)

Macroautophagy is a self-cannibalistic process that enables cells to adapt to various stresses and maintain energy homeostasis. Additionally, autophagy is an important route for turnover of misfolded proteins and damaged organelles, with important implications in cancer, neurodegenerative diseases and aging. Resveratrol and spermidine are able to induce autophagy by affecting deacetylases and acetylases, respectively, and have been found to extend the life-span of model organisms.

Author(s): 
Bennetzen, Martin V.
MariÒo, Guillermo
Pultz, Dennis
Morselli, Eugenia
FÊrgeman, Nils J.
Kroemer, Guido
Andersen, Jens S.
Publication Title: 
Oncology Reports

SIRT1 is the human orthologue of SIR2, a conserved NAD-dependent protein deacetylase that regulates longevity in yeast and in Caenorhabditis elegans. Overexpression of SIRT1 in cancer tissue, compared with normal tissue, has been demonstrated, suggesting that SIRT1 may act as a tumor promoter. The function of SIRT1 in liver cancer has not been elucidated. In the present study, SIRT1 re-expression or knockdown was induced in hepatoma cell lines and liver normal cell lines.

Author(s): 
Wang, Hanning
Liu, Hao
Chen, Kaiyun
Xiao, Jinfeng
He, Ke
Zhang, Jinqian
Xiang, Guoan
Publication Title: 
PloS One

BACKGROUND: Activation of hepatic stellate cells (HSCs) plays an important role in the development of cirrhosis through the increased production of collagen. p53, the "guardian of the genome", is a transcription factor that can bind to promoter regions of hundreds of genes where it either activates or suppresses gene expression. Thereby, p53 serves as a tumor suppressor by inducing cell cycle arrest, apoptosis, senescence and DNA repair. Artesunate is a derivative of Artemisinin, Scholars had found it had more extensive pharmacological effects past 10 years.

Author(s): 
Longxi, Peng
Buwu, Fang
Yuan, Wang
Sinan, Gao
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Though Mica, a thin and sheet like mineral, has been used as a mineral medicine for treatment of bleeding, dysentery and inflammation in traditional medicine including Ayurveda, the biological evidences of Mica were not clearly elucidated so far. Thus, in the present study, the antitumor mechanism of particled Mica (STB-HO) was examined in colorectal cancers.

Author(s): 
Cho, Sung-Yun
Lee, Hyo-Jeong
Cho, Sun-Mi
Kim, Bonglee
Jung, Yeon Kwon
Kim, Sung-Hoon
Publication Title: 
Cell Proliferation

OBJECTIVES: Gymnema montanum Hook, an Indian Ayurvedic medicinal plant, is used traditionally to treat a variety of ailments. Here, we report anti-cancer effects and molecular mechanisms of ethanolic extract of G. montanum (GLEt) on human leukaemia HL-60 cells, compared to peripheral blood mononuclear cells. MATERIALS AND METHODS: HL-60 cells were treated with different concentrations of GLEt (10-50 μg/ml) and cytotoxicity was assessed by MTT assay. Levels of lipid peroxidation, antioxidants, mitochondrial membrane potential and caspase-3 were measured.

Author(s): 
Ramkumar, K. M.
Manjula, C.
Elango, B.
Krishnamurthi, K.
Saravana Devi, S.
Rajaguru, P.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Though Mica, a thin and sheet like mineral, has been used as a mineral medicine for treatment of bleeding, dysentery and inflammation in traditional medicine including Ayurveda, the biological evidences of Mica were not clearly elucidated so far. Thus, in the present study, the antitumor mechanism of particled Mica (STB-HO) was examined in colorectal cancers.

Author(s): 
Cho, Sung-Yun
Lee, Hyo-Jeong
Cho, Sun-Mi
Kim, Bonglee
Jung, Yeon Kwon
Kim, Sung-Hoon
Publication Title: 
Journal of Biomedicine & Biotechnology

Ulcerative colitis (UC) is debilitating and carries a high colon cancer risk. Apoptosis of inflammatory cells is a key mechanism regulating UC. We have recently shown that American ginseng (AG), and to a greater extent, a Hexane fraction of AG (HAG) can cause apoptosis and suppress mouse colitis through a p53-mediated mechanism. Here, we tested the hypothesis that HAG suppresses colitis through a p53 mechanism. We found only a limited impact of p53 in the ability of HAG to induce inflammatory cell apoptosis and suppress mouse colitis in vitro and in vivo.

Author(s): 
Poudyal, Deepak
Cui, Xiangli
Mai Le, Phuong
Davis, Tia
Hofseth, Anne B.
Jin, Yu
Chumanevich, Alexander A.
Wargovich, Michael J.
Nagarkatti, Mitzi
Nagarkatti, Prakash S.
Windust, Anthony
Hofseth, Lorne J.
Publication Title: 
Cancer Letters

This study examined the effect of 3, 9-dihydroxy-2-prenylcoumestan (pso), a furanocoumarin, on PC-3 and C4-2B castration-resistant prostate cancer (CRPC) cell lines. Pso caused significant G0/G1 cell cycle arrest and inhibition of cell growth. Molecular analysis of cyclin (D1, D2, D3, and E), cyclin-dependent kinase (cdk) (cdks 2, 4, and 6), and cdk inhibitor (p21 and p27) expression suggested transcriptional regulation of the cdk inhibitors and more significant downregulation of cdk4 than of cyclins or other cdks.

Author(s): 
Gulappa, Thippeswamy
Reddy, Ramadevi Subramani
Suman, Suman
Nyakeriga, Alice M.
Damodaran, Chendil
Publication Title: 
PloS One

BACKGROUND: Cancer is one of the highly virulent diseases known to humankind with a high mortality rate. Breast cancer is the most common cancer in women worldwide. Sorghum is a principal cereal food in many parts of the world, and is critical in folk medicine of Asia and Africa. In the present study, we analyzed the effects of HSE in metastatic breast cancer. METHODOLOGY/PRINCIPAL FINDINGS: Preliminary studies conducted on MDA-MB 231 and MCF-7 xenograft models showed tumor growth suppression by HSE.

Author(s): 
Park, Jin Hee
Darvin, Pramod
Lim, Eun Joung
Joung, Youn Hee
Hong, Dae Young
Park, Eui U.
Park, Seung Hwa
Choi, Soo Keun
Moon, Eon-Soo
Cho, Byung Wook
Park, Kyung Do
Lee, Hak Kyo
Kim, Myong-Jo
Park, Dong-Sik
Chung, Ill-Min
Yang, Young Mok

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