Galactose

Publication Title: 
Cell Stem Cell

Calorie restriction (CR) extends life span and ameliorates age-related pathologies in most species studied, yet the mechanisms underlying these effects remain unclear. Using mouse skeletal muscle as a model, we show that CR acts in part by enhancing the function of tissue-specific stem cells. Even short-term CR significantly enhanced stem cell availability and activity in the muscle of young and old animals, in concert with an increase in mitochondrial abundance and induction of conserved metabolic and longevity regulators.

Author(s): 
Cerletti, Massimiliano
Jang, Young C.
Finley, Lydia W. S.
Haigis, Marcia C.
Wagers, Amy J.
Publication Title: 
Experimental Gerontology

We have previously shown that autophagy is required for chronological longevity in the budding yeast Saccharomyces cerevisiae. Here we examine the requirements for autophagy during extension of chronological life span (CLS) by calorie restriction (CR). We find that autophagy is upregulated by two CR interventions that extend CLS: water wash CR and low glucose CR. Autophagy is required for full extension of CLS during water wash CR under all growth conditions tested.

Author(s): 
Aris, John P.
Alvers, Ashley L.
Ferraiuolo, Roy A.
Fishwick, Laura K.
Hanvivatpong, Amanda
Hu, Doreen
Kirlew, Christine
Leonard, Michael T.
Losin, Kyle J.
Marraffini, Michelle
Seo, Arnold Y.
Swanberg, Veronica
Westcott, Jennifer L.
Wood, Michael S.
Leeuwenburgh, Christiaan
Dunn, William A.
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Malaria, caused by Plasmodium sp, results in almost one million deaths and over 200 million new infections annually. The World Health Organization has recommended that artemisinin-based combination therapies be used for treatment of malaria. Artemisinin is a sesquiterpene lactone isolated from the plant Artemisia annua. However, the supply and price of artemisinin fluctuate greatly, and an alternative production method would be valuable to increase availability.

Author(s): 
Westfall, Patrick J.
Pitera, Douglas J.
Lenihan, Jacob R.
Eng, Diana
Woolard, Frank X.
Regentin, Rika
Horning, Tizita
Tsuruta, Hiroko
Melis, David J.
Owens, Andrew
Fickes, Scott
Diola, Don
Benjamin, Kirsten R.
Keasling, Jay D.
Leavell, Michael D.
McPhee, Derek J.
Renninger, Neil S.
Newman, Jack D.
Paddon, Chris J.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The polyherbal eye drop (Itone™) is a mixture of aqueous distillates of nineteen traditionally used ingredients that sum up to impart potency to the formulation and make it a useful adjunct in various ocular pathologies. However, as there have been no controlled experimental studies accounting to the above claim, therefore, the present study was designed to evaluate the polyherbal formulation (PHF) for antiangiogenic, anti-inflammatory, anticataract, antioxidant and cytotoxicity in addition to the evaluation of intraocular penetration of PHF in rabbit eyes using LC-MS/MS.

Author(s): 
Velpandian, Thirumurthy
Gupta, Pankaj
Ravi, Alok Kumar
Sharma, Hanuman Prasad
Biswas, Nihar Ranjan
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The polyherbal eye drop (Itone™) is a mixture of aqueous distillates of nineteen traditionally used ingredients that sum up to impart potency to the formulation and make it a useful adjunct in various ocular pathologies. However, as there have been no controlled experimental studies accounting to the above claim, therefore, the present study was designed to evaluate the polyherbal formulation (PHF) for antiangiogenic, anti-inflammatory, anticataract, antioxidant and cytotoxicity in addition to the evaluation of intraocular penetration of PHF in rabbit eyes using LC-MS/MS.

Author(s): 
Velpandian, Thirumurthy
Gupta, Pankaj
Ravi, Alok Kumar
Sharma, Hanuman Prasad
Biswas, Nihar Ranjan
Publication Title: 
Glycobiology

Bovine milk oligosaccharides (BMOs) are recognized by the dairy and food industries, as well as by infant formula manufacturers, as novel, high-potential bioactive food ingredients. Recent studies revealed that bovine milk contains complex oligosaccharides structurally related to those previously thought to be present in only human milk. These BMOs are microbiotic modulators involved in important biological activities, including preventing pathogen binding to the intestinal epithelium and serving as nutrients for a selected class of beneficial bacteria.

Author(s): 
Aldredge, Danielle L.
Geronimo, Maria R.
Hua, Serenus
Nwosu, Charles C.
Lebrilla, Carlito B.
Barile, Daniela
Publication Title: 
Biological & Pharmaceutical Bulletin

Colla corii asini (E'jiao), donkey-hide gelatin prepared by stewing and concentrating from Equus asinus L. donkey hide, is a traditional Chinese medicine preparation widely used in clinical hematic antanemic therapy in China. The aim of the present study was to investigate potential anti-aging effect of Colla corii asini and explore related mechanisms in D-galactose (gal) induced aging model mice. The mice were artificially induced aging by subcutaneously injection with D-gal at the dose of 100 mg/kg·d for 8 weeks.

Author(s): 
Wang, Dongliang
Liu, Maoxuan
Cao, Jichao
Cheng, Yanna
Zhuo, Chen
Xu, Hongyan
Tian, Shousheng
Zhang, Yan
Zhang, Jian
Wang, Fengshan
Publication Title: 
Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan / Sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine

OBJECTIVE: To observe the regulative effect of auricular acupuncture, moxibustion and Chinese herbs on immunologic function in the D-galactose-induced aging mouse and to probe the feasibility and possible mechanisms for delaying aging, so as to provide experimental basis for acupuncture, moxibustion and Chinese herbs for delaying aging.

Author(s): 
Xie, Su
Ling, Xiangli
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